CALPEPTIN
- CAS No.
- 117591-20-5
- Chemical Name:
- CALPEPTIN
- Synonyms
- CS-1747;CALPEPTIN;Z-LEU-NLE-OH;Calpeptin,95%;Z-LEU-NLE-CHO;Z-LEU-NORLEUCINAL;N-CBZ-L-LEUCYL-NORLEUCINAL;BENZYLOXYCARBONYLLEUCYL-NORLEUCINAL;BENZYLOXYCARBONYLDIPEPTIDYL ALDEHYDE;N-BENZYLOXYCARBONYL-L-LEUCYLNORLEUCINAL
- CBNumber:
- CB4713515
- Molecular Formula:
- C20H30N2O4
- Molecular Weight:
- 362.46
- MOL File:
- 117591-20-5.mol
- MSDS File:
- SDS
- Modify Date:
- 2023/7/14 17:44:35
| Melting point | 60-75 °C |
|---|---|
| Boiling point | 494.07°C (rough estimate) |
| Density | 1.1667 (rough estimate) |
| refractive index | 1.6800 (estimate) |
| storage temp. | -20°C |
| solubility | Soluble in DMSO at 15mg/ml |
| form | White to off-white solid |
| pka | 11.14±0.46(Predicted) |
| color | white to beige |
| InChIKey | PGGUOGKHUUUWAF-ROUUACIJSA-N |
| CAS DataBase Reference | 117591-20-5(CAS DataBase Reference) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P280-P301+P312-P302+P352-P305+P351+P338 |
| Safety Statements | 24/25 |
| WGK Germany | 3 |
| HS Code | 29242990 |
CALPEPTIN price More Price(5)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | C8999 | Calpeptin ≥98% (HPLC) | 117591-20-5 | 5MG | ₹10727.58 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 03-34-0051 | Calpeptin - CAS 117591-20-5 - Calbiochem A cell-permeable calpain inhibitor (ID?? = 52 nM for calpain-1; ID?? = 34 nM for calpain-2; ID?? = 138 nM for papain). | 117591-20-5 | 5MG | ₹13430.01 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | C8999 | Calpeptin ≥98% (HPLC) | 117591-20-5 | 25MG | ₹43830.43 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 03-34-0051 | Calpeptin - CAS 117591-20-5 - Calbiochem A cell-permeable calpain inhibitor (ID?? = 52 nM for calpain-1; ID?? = 34 nM for calpain-2; ID?? = 138 nM for papain). | 117591-20-5 | 25MG | ₹32230 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 03-34-0051 | Calpeptin - CAS 117591-20-5 - Calbiochem A cell-permeable calpain inhibitor (ID?? = 52 nM for calpain-1; ID?? = 34 nM for calpain-2; ID?? = 138 nM for papain). | 117591-20-5 | 100MG | ₹94520 | 2022-06-14 | Buy |
CALPEPTIN Chemical Properties,Uses,Production
Chemical Properties
white to off-white powder
Uses
Calpeptin is used to to inhibit the activities of cathepsin L and calpain-1. Calpeptin blocked the expression of aspartyl protease cathepsin D, amyloid precursor protein, and calparin. It acts as an inhibitor of the Ca2+-dependent protease, calpain. Prevents collagen- and thrombin-induced platelet aggregation, probably by blocking calpain induced phospholipase C and thromboxane synthase activation. Potent cathepsin L inhibitor. It is shown to preferentially inhibit a subset of protein-tyrosine phosphatases.
General Description
Calpeptin (Z-Leu-nLeu-H) is a cell permeable, peptide aldehyde inhibitor. It is more sensitive to calpain I compared to other inhibitors, such as Z-Leu-Met-H and leupeptin. Calpeptin stimulates neurite elongation in differentiating pheochromocytoma (PC12) cells. Calpeptin decreases microgliosis, astrogliosis, axonal damage and neuron and oligodendrocyte death in experimental autoimmune encephalomyelitis (EAE) spinal cord. Therefore, it can be considered as a potent therapeutic for treating EAE and multiple sclerosis (MS).
Biological Activity
Potent, cell-permeable inhibitor of the Ca 2+ -dependent protease, calpain. Prevents collagen- and thrombin-induced platelet aggregation, probably by blocking calpain induced phospholipase C and thromboxane synthase activation. Potent cathepsin L inhibitor. Recently shown to preferentially inhibit a subset of protein-tyrosine phosphatases.
CALPEPTIN Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| Alpha Biopharmaceuticals Co., Ltd | +86-15542445688 | China | 888 | 58 | Inquiry |
| BOC Sciences | +1-631-485-4226 | United States | 19553 | 58 | Inquiry |
| Career Henan Chemica Co | +86-0371-86658258 +8613203830695 | China | 30253 | 58 | Inquiry |
| Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471 | China | 10522 | 58 | Inquiry |
| Nextpeptide Inc | +86-0571-81612335 +8613336028439 | China | 19915 | 58 | Inquiry |
| InvivoChem | +1-708-310-1919 +1-13798911105 | United States | 6393 | 58 | Inquiry |
| TargetMol Chemicals Inc. | +1-781-999-5354 | United States | 19973 | 58 | Inquiry |
| ShenZhen Trendseen Biological Technology Co.,Ltd. | 13417589054 | China | 11681 | 58 | Inquiry |
| LEAPCHEM CO., LTD. | +86-852-30606658 | China | 43348 | 58 | Inquiry |
| Aladdin Scientific | +1-+1(833)-552-7181 | United States | 57511 | 58 | Inquiry |