Mannitol
- CAS No.
- 87-78-5
- Chemical Name:
- Mannitol
- Synonyms
- MANNITOL BP;MANNITOL USP;Maitol;DL-Mannitol;Hexahydroxyhexane;Cordycepin 10% Mannitol;NSC 9256;MANNITOL;MANNITOL B;Mannidex 16700
- CBNumber:
- CB4720971
- Molecular Formula:
- C6H14O6
- Molecular Weight:
- 182.17
- MOL File:
- 87-78-5.mol
- MSDS File:
- SDS
- Modify Date:
- 2024/8/1 17:24:36
| Melting point | 167°C |
|---|---|
| Boiling point | 494.9°C |
| Density | 1.596 |
| refractive index | 1.5970 (estimate) |
| storage temp. | Inert atmosphere,Room Temperature |
| pka | pKa 13.50(H2O,t =18)(Approximate) |
| form | Solid |
| color | White to off-white |
| Water Solubility | 177.3g/L(25 ºC) |
| Dielectric constant | 3.0（22℃） |
| InChI | InChI=1S/C6H14O6/c7-1-3(9)5(11)6(12)4(10)2-8/h3-12H,1-2H2/t3-,4-,5-,6-/m1/s1 |
| InChIKey | FBPFZTCFMRRESA-KVTDHHQDSA-N |
| SMILES | OC[C@H]([C@H]([C@@H]([C@@H](CO)O)O)O)O |
| CAS DataBase Reference | 87-78-5(CAS DataBase Reference) |
| EPA Substance Registry System | Mannitol (87-78-5) |
Mannitol Chemical Properties,Uses,Production
Description
It can be used to lower intraocular pressure and in the postoperational period in ophthalomological procedures as well as during brain edema.
Chemical Properties
D-mannitol (D-mannohexan-1.2.3.4.5.6-hexaol) is a constituent of several plants
including the Manna ash, several edible plants, and seaweed. Parts of the latter
contain up to 10 % mannitol by weight. The solubility in water is approximately 230 g/L at room temperature and it increases with increasing temperature. Mannitol
is stable under the common processing conditions of foods.
Mannitol is approximately 50 % as sweet as sucrose and non-cariogenic.
In the European Union, maltitol is approved as E 421 for a large number of food
applications. In the United States, mannitol produced by hydrogenation of glucose
or fructose solutions or by fermentation by Zygosaccharomyces rouxii or Lactobacillus
intermedius is approved for several food applications. It is also approved
in many other countries.
Uses
Mannitol is a polyol (polyhydric alcohol) produced from hydrogena- tion from fructose that functions as a sweetener, humectant, and bulking agent. it has low hygroscopicity and poor oil solvency. it has 1.6 kcal/g. it is approximately 22% soluble in water and is approximately 72% as sweet as sugar, exhibiting a cool, sweet taste. it functions as a dusting agent with starch in chewing gum. it is used in sugarless candy, chewing gum, cereal, and pressed mints.
Definition
mannitol: A polyhydric alcohol,CH2OH(CHOH)4CH2OH, derived frommannose or fructose. It is the mainsoluble sugar in fungi and an importantcarbohydrate reserve in brownalgae. Mannitol is used as a sweetenerin certain foodstuffs and as a diureticto relieve fluid retention.
Mechanism of action
Today, mannitol is the most widely used osmotic diuretic. It raises osmotic pressure in renal tubules, thus reducing reabsorption of water in the nephrons. As a result, a large quantity of free water is released, sodium secretion increases, and as a rule, an insignificant amount of potassium is secreted. Mannitol is used as an adjuvant drug for preventing oliguria and anuriua.
Clinical Use
Mannitol is the agent most commonly used as an osmotic diuretic. Sorbitol also can be used for similar reasons.Mannitol is administered intravenously in solutions of 5 to 50% at a rate of administration that is adjusted to maintain the urinary output at 30 to 50 ml/hour. Mannitol is filtered at the glomerulus and is poorly reabsorbed by the kidney tubule. The osmotic effect of mannitol in the tubule inhibits the reabsorption of water, and the rate of urine flow can be maintained. It also is used to reduce intracranial pressure by reducing cerebral intravascular volume.
Safety Profile
A poison by intravenous route. Human systemic effects. When heated to decomposition it emits acrid smoke and irritating vapors.
Mannitol Preparation Products And Raw materials
Raw materials
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chevron_rightPreparation Products
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| Macleods Pharmaceuticals Limited | +91-2266762800 +91-2266762800 | Maharashtra, India | 116 | 58 | Inquiry |
| HRV Global Life Sciences | +91-9820219686 +91-9820219686 | Telangana, India | 379 | 58 | Inquiry |
| Ankit Pulps and Boards Pvt. Ltd. APB | +91-9970057671 +91-7666900215 | Maharashtra, India | 10 | 58 | Inquiry |
| Arihant Innochem Pvt Ltd | +91-2267674895 +91-2267674895 | Mumbai, India | 37 | 58 | Inquiry |
| Mb Sugars And Pharmaceuticals Ltd | +91-9326192190 +91-9822651942 | Maharashtra, India | 4 | 58 | Inquiry |
| SD FINE CHEM LTD | 91-22-24959898/99 | New Delhi, India | 41 | 58 | Inquiry |
| Maas Pharma Chemicals | +91-9958666224 | Delhi, India | 1607 | 58 | Inquiry |
| CLEARSYNTH LABS LTD. | +91-22-45045900 | Hyderabad, India | 6351 | 58 | Inquiry |
| A.J Chemicals | 91-9810153283 | New Delhi, India | 6124 | 58 | Inquiry |
| Satija Chemicals | 07942544704 | Delhi, India | 72 | 58 | Inquiry |
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