D-Mannitol
- CAS No.
- 69-65-8
- Chemical Name:
- D-Mannitol
- Synonyms
- Hexitol;Cordycepic acid;MANNITOL GRANULAR;MANNITE;Mannitol CRS;mannopyranose;mannitose;d-mannito;Bronchitol;Resectisol
- CBNumber:
- CB7720972
- Molecular Formula:
- C6H14O6
- Molecular Weight:
- 182.17
- MOL File:
- 69-65-8.mol
- MSDS File:
- SDS
- Modify Date:
- 2025/1/27 9:38:02
| Melting point | 167-170 °C(lit.) |
|---|---|
| Boiling point | 295°C |
| alpha | 141 º (c= USP-directives) |
| Density | 1.52 |
| bulk density | 400-500kg/m3 |
| refractive index | 1.3330 (estimate) |
| Flash point | 290-295°C/3.5mm |
| storage temp. | 2-8°C |
| solubility | H2O: 1 M at 20 °C, clear, colorless |
| form | Crystalline Powder |
| pka | 13.5(at 18℃) |
| color | White |
| Odor | at 100.00 %. odorless |
| PH | 5.0-6.5 (25℃, 1M in H2O) |
| optical activity | [α]25/D +23.3 to +24.3°(lit.) |
| Odor Type | odorless |
| biological source | plant |
| Water Solubility | soluble |
| λmax |
λ: 260 nm Amax: 0.04 λ: 280 nm Amax: 0.04 |
| Merck | 14,5745 |
| BRN | 1721898 |
| Stability | Stable. Combustible. Incompatible with strong oxidizing agents. |
| InChIKey | FBPFZTCFMRRESA-KVTDHHQDSA-N |
| LogP | -3.262 (est) |
| CAS DataBase Reference | 69-65-8(CAS DataBase Reference) |
| NIST Chemistry Reference | D-Mannitol(69-65-8) |
| EPA Substance Registry System | D-Mannitol (69-65-8) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302+H312+H332 | |||||||||
| Precautionary statements | P280 | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 24/25-36-26 | |||||||||
| WGK Germany | 2 | |||||||||
| RTECS | OP2060000 | |||||||||
| F | 3 | |||||||||
| Autoignition Temperature | 410 °C | |||||||||
| TSCA | Yes | |||||||||
| HS Code | 29054300 | |||||||||
| Hazardous Substances Data | 69-65-8(Hazardous Substances Data) | |||||||||
| Toxicity | LD50 orally in Rabbit: 13500 mg/kg | |||||||||
| NFPA 704 |
|
D-Mannitol price More Price(51)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | M9647 | D-Mannitol ACS reagent | 69-65-8 | 250G | ₹3477 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | M9647 | D-Mannitol ACS reagent | 69-65-8 | 500G | ₹6014.6 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | PHR1007 | Mannitol Pharmaceutical Secondary Standard; Certified Reference Material | 69-65-8 | 1G | ₹9418.4 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | M9647 | D-Mannitol ACS reagent | 69-65-8 | 1KG | ₹11102 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | M9647 | D-Mannitol ACS reagent | 69-65-8 | 10KG | ₹114704.4 | 2022-06-14 | Buy |
D-Mannitol Chemical Properties,Uses,Production
Description
Mannitol is a white, crystalline solid consisting of D-mannitol and a small quantity of sorbitol. It is odorless and has a sweet taste. It is soluble in water, very slightly soluble in alcohol, and practically insoluble in most other common organic solvents. It is prepared commercially by catalytic reduction of glucose. Mannitol occurs in small amounts in a variety of foods such as olives, beets, and celery, and in the exudate of certain trees.
Chemical Properties
Mannitol is D-mannitol. It is a hexahydric alcohol related to mannose and is isomeric with sorbitol. D-Mannitol is widespread in plants and plant exudates; obtained from manna and seaweeds. Mannitol occurs as a white, odorless, crystalline powder, or freeflowing granules. It has a sweet taste, approximately as sweet as glucose and half as sweet as sucrose, and imparts a cooling sensation in the mouth. Microscopically, it appears as orthorhombic needles when crystallized from alcohol. Mannitol shows polymorphism.
Uses
D-Mannitol is used in the food industry as anticaking and free-flow agent, flavo ring agent, lubricant and release agent, stabilizer and thickener and nutritive sweetener.
Used in titrimetric determination of boric acid in the manufacture of dry electrolytic condensers for radio applications;
Used in making artificial resins and plasticizers.
Production Methods
Mannitol may be extracted from the dried sap of manna and other natural sources by means of hot alcohol or other selective solvents. It is commercially produced by the catalytic or electrolytic reduction of monosaccharides such as mannose and glucose.
Definition
ChEBI: D-mannitol is the D-enantiomer of mannitol. It has a role as an osmotic diuretic, a sweetening agent, an antiglaucoma drug, a metabolite, an allergen, a hapten, a food bulking agent, a food anticaking agent, a food humectant, a food stabiliser, a food thickening agent, an Escherichia coli metabolite and a member of compatible osmolytes.
General Description
Odorless white crystalline powder or free-flowing granules. Sweet taste.
Air & Water Reactions
Water soluble.
Reactivity Profile
A sugar alcohol. More closely related to carbohydrates than to other polyhydric alcohols [Noller]. Flammable and/or toxic gases are generated by the combination with alkali metals, nitrides, strong reducing agents and strong oxidizing agents.
Hazard
Mildly toxic; mutagen.
Fire Hazard
D-Mannitol is probably combustible.
Safety
Mannitol is a naturally occurring sugar alcohol found in animals
and plants; it is present in small quantities in almost all vegetables.
Laxative effects may occur if mannitol is consumed orally in large
quantities.If it is used in foods as a bodying agent and daily
ingestion of over 20g is foreseeable, the product label should bear
the statement ‘excessive consumption may have a laxative effect’.
After intravenous injection, mannitol is not metabolized to any
appreciable extent and is minimally reabsorbed by the renal tubule,
about 80% of a dose being excreted in the urine in 3 hours.
A number of adverse reactions to mannitol have been reported,
primarily following the therapeutic use of 20% w/v aqueous
intravenous infusions.The quantity of mannitol used as an
excipient is considerably less than that used therapeutically and is
consequently associated with a lower incidence of adverse reactions.
However, allergic, hypersensitive-type reactions may occur when
mannitol is used as an excipient.
An acceptable daily intake of mannitol has not been specified by
the WHO since the amount consumed as a sweetening agent was
not considered to represent a hazard to health.
LD50 (mouse, IP): 14 g/kg
LD50 (mouse, IV): 7.47 g/kg
LD50 (mouse, oral): 22 g/kg
LD50 (rat, IV): 9.69 g/kg
LD50 (rat, oral): 13.5 g/kg
storage
Mannitol is stable in the dry state and in aqueous solutions.
Solutions may be sterilized by filtration or by autoclaving and if
necessary may be autoclaved repeatedly with no adverse physical or
chemical effects.In solution, mannitol is not attacked by cold,
dilute acids or alkalis, nor by atmospheric oxygen in the absence of
catalysts. Mannitol does not undergo Maillard reactions.
The bulk material should be stored in a well-closed container in a
cool, dry place.
Purification Methods
D-Mannitol is crystallised from EtOH, MeOH or H2O and dried at 100o. [Thomson Acta Chem Scand 6 270, 279, 280 1952, Beilstein 1 IV 2841.]
Incompatibilities
Mannitol solutions, 20% w/v or stronger, may be salted out by potassium chloride or sodium chloride.Precipitation has been reported to occur when a 25% w/v mannitol solution was allowed to contact plastic.Sodium cephapirin at 2 mg/mL and 30 mg/mL concentration is incompatible with 20% w/v aqueous mannitol solution. Mannitol is incompatible with xylitol infusion and may form complexes with some metals such as aluminum, copper, and iron. Reducing sugar impurities in mannitol have been implicated in the oxidative degradation of a peptide in a lyophilized formation.Mannitol was found to reduce the oral bioavailability of cimetidine compared to sucrose.
Regulatory Status
GRAS listed. Accepted for use as a food additive in Europe. Included in the FDA Inactive Ingredients Database (IP, IM, IV, and SC injections; infusions; buccal, oral and sublingual tablets, powders and capsules; ophthalmic preparations; topical solutions). Included in nonparenteral and parenteral medicines licensed in the UK. Included in the Canadian List of Acceptable Mon-medicinal Ingredients.
D-Mannitol Preparation Products And Raw materials
Raw materials
Preparation Products
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chevron_right| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| Frolic Pharmachem | +919711094561 | Himachal Pradesh, India | 94 | 58 | Inquiry |
| Ralington Pharma | +91-7948911722 +91-9687771722 | Gujarat, India | 1350 | 58 | Inquiry |
| S D Fine Chem Limited | +91-9323715856 +91-9323715856 | Maharashtra, India | 368 | 58 | Inquiry |
| Gangwal Healthcare Pvt Ltd | +91-9320779960 | Maharashtra, India | 51 | 58 | Inquiry |
| RYZE CHEMIE | +91-9702966440 +91-9702966440 | Maharashtra, India | 335 | 58 | Inquiry |
| ARRAKIS INDUSTRIES LLP | +91 74995 32711 | Maharashtra, India | 1353 | 58 | Inquiry |
| JSK Chemicals | +919879767970 | Gujarat, India | 3756 | 58 | Inquiry |
| Azole Rasayanas India Private Limited | 91-40-29707735 | Hyderabad, India | 681 | 58 | Inquiry |
| Pharma Affiliates | 172-5066494 | Haryana, India | 6754 | 58 | Inquiry |
| TCI Chemicals (India) Pvt. Ltd. | 1800 425 7889 | New Delhi, India | 6768 | 58 | Inquiry |
| Supplier | Advantage |
|---|---|
| Frolic Pharmachem | 58 |
| Ralington Pharma | 58 |
| S D Fine Chem Limited | 58 |
| Gangwal Healthcare Pvt Ltd | 58 |
| RYZE CHEMIE | 58 |
| ARRAKIS INDUSTRIES LLP | 58 |
| JSK Chemicals | 58 |
| Azole Rasayanas India Private Limited | 58 |
| Pharma Affiliates | 58 |
| TCI Chemicals (India) Pvt. Ltd. | 58 |
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