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ChemicalBook > Product Catalog >Pharmaceutical intermediates >Heterocyclic compound >Pyridine compound >Pyridine derivatives >4-Iodo-2-(trifluoromethyl)pyridine

4-Iodo-2-(trifluoromethyl)pyridine

4-Iodo-2-(trifluoromethyl)pyridine Structure
CAS No.
590371-73-6
Chemical Name:
4-Iodo-2-(trifluoromethyl)pyridine
Synonyms
4-lodo-2-(trifluoromethyl)pyridine;2-(trifluoroMethyl)-4-iodopyridine;4-IODO-2-(TRIFLUOROMETHYL)PYRIDINE;4-IODE-2-(TRIFLUOROMETHYL)PYRIDINE;Pyridine,4-iodo-2-(trifluoromethyl)-;4-Iodo-2-(trifluoromethyl)pyridine97%;4-Iodo-2-(trifluoromethyl)pyridine 97%;4-Iodo-2-(trifluoromethyl)pyridine ISO 9001：2015 REACH;4-Iode-2-(trifluoromethyl)pyridine (not restricted/prohibited)(lab chemical)
CBNumber:
CB4722177
Molecular Formula:
C6H3F3IN
Molecular Weight:
272.99
MOL File:
590371-73-6.mol
MSDS File:
SDS
Modify Date:
2023/10/17 11:53:47
Request For Quotation

4-Iodo-2-(trifluoromethyl)pyridine Properties

Melting point 24-26 °C
Boiling point 206.2±35.0 °C(Predicted)
Density 1.974g/ml
storage temp. under inert gas (nitrogen or Argon) at 2–8 °C
form liquid
pka -0.82±0.20(Predicted)
color Clear, colourless to pale yellow

SAFETY

Risk and Safety Statements

Symbol(GHS) 
GHS07
Signal word  Warning
Hazard statements  H227-H315-H319-H335
Precautionary statements  P305+P351+P338
Hazard Codes  Xi
HazardClass  IRRITANT
HS Code  2933399990

4-Iodo-2-(trifluoromethyl)pyridine Chemical Properties,Uses,Production

Uses

4-Iodo-2-(trifluoromethyl)pyridine is used as a reagent in the synthesis of aminoisoindoles as β-site amyloid precursor protein cleaving enzyme 1 (BACE1) inhibitors which exhibit in vivo brain reduction of β-amyloid peptides.

Reactivity Profile

4-Iodo-2-(trifluoromethyl)pyridine could be cleanly deprotonated by LIDA in tetrahydrofuran at –75 °C[1]. Trapping of the organometallic intermediates with dry ice followed by neutralization gave the 4-iodo-2-(trifluoromethyl)pyridine-3-carboxylic acid (16, 31%). a: LIDA in THF at –75 °C for 2 h; b: (1.) Excess solid carbon dioxide, (2.) Hydrochloric acid.4-Iodo-2-(trifluoromethyl)pyridine

References

[1] Schlosser M, et al. Further Metalations and Functionalizations of Chloro-, Bromo- and Iodo(trifluoromethyl)pyridines. Synthesis, 2004; 10: 1619-1624.

4-Iodo-2-(trifluoromethyl)pyridine Preparation Products And Raw materials

Raw materials

Preparation Products

2-(Trifluoromethyl)isonicotinic acid 2-(Trifluoromethyl)pyridine-4-boronic acid

4-Iodo-2-(trifluoromethyl)pyridine Suppliers

Global( 110)Suppliers
Supplier Tel Country ProdList Advantage Inquiry
A.J Chemicals 91-9810153283 New Delhi, India 6100 58 Inquiry
CHEMSWORTH +91-261-2397244 New Delhi, India 6700 30 Inquiry
Shanghai Boc Chemical Co., Ltd. 021-34975602; +8618721111801 China 138 58 Inquiry
ATK CHEMICAL COMPANY LIMITED +undefined-21-51877795 China 33024 60 Inquiry
career henan chemical co +86-0371-86658258 +8613203830695 China 29858 58 Inquiry
CONIER CHEM AND PHARMA LIMITED +8618523575427 China 49732 58 Inquiry
Fuxin Pharmaceutical +86-021-021-50872116 +8613122107989 China 10035 58 Inquiry
Guangzhou Yuheng Pharmaceutical Technology Co., Ltd +8613580539051 CHINA 21142 58 Inquiry
ANHUI WITOP BIOTECH CO., LTD +8615255079626 China 23541 58 Inquiry
Dideu Industries Group Limited +86-29-89586680 +86-15129568250 China 22854 58 Inquiry
Supplier Advantage
A.J Chemicals 58
CHEMSWORTH 30
Shanghai Boc Chemical Co., Ltd. 58
ATK CHEMICAL COMPANY LIMITED 60
career henan chemical co 58
CONIER CHEM AND PHARMA LIMITED 58
Fuxin Pharmaceutical 58
Guangzhou Yuheng Pharmaceutical Technology Co., Ltd 58
ANHUI WITOP BIOTECH CO., LTD 58
Dideu Industries Group Limited 58

4-Iodo-2-(trifluoromethyl)pyridine Spectrum

4-Iodo-2-(trifluoromethyl)pyridine(590371-73-6)1HNMR

590371-73-6(4-Iodo-2-(trifluoromethyl)pyridine )Related Search:

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3-(Trifluoromethyl)benzaldehyde Azamethiphos Trimethylsulfoxonium iodide Trifluoromethanesulfonic anhydride 4-(Trifluoromethyl)pyridine
3-（trifluoromethyl) Cinnamaldehyde Pyridine 3-Trifluoromethylpyridine 4-Iodo-2-methylpyridine 2-Iodo-5-trifluoromethylpyridine
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4-Iodo-2-(trifluoromethyl)pyridine97% 4-Iodo-2-(trifluoromethyl)pyridine 97% 4-IODO-2-(TRIFLUOROMETHYL)PYRIDINE 2-(trifluoroMethyl)-4-iodopyridine Pyridine,4-iodo-2-(trifluoromethyl)- 4-IODE-2-(TRIFLUOROMETHYL)PYRIDINE 4-Iodo-2-(trifluoromethyl)pyridine ISO 9001：2015 REACH 4-Iode-2-(trifluoromethyl)pyridine (not restricted/prohibited)(lab chemical) 4-lodo-2-(trifluoromethyl)pyridine 590371-73-6 1250277-69-2 Pyridine Pyridine series Halides Pyridines Heterocycle Fluorine series