1-Hexadecanol
- CAS No.
- 36653-82-4
- Chemical Name:
- 1-Hexadecanol
- Synonyms
- CETYL ALCOHOL;HEXADECANOL;HEXADECAN-1-OL;Ethol;CETANOL;Lipocol C;n-Hexadecanol;Cetylic alcohol;Cetylol;Cetyl alcohol NF
- CBNumber:
- CB4853561
- Molecular Formula:
- C16H34O
- Molecular Weight:
- 242.44
- MOL File:
- 36653-82-4.mol
- MSDS File:
- SDS
- Modify Date:
- 2024/8/24 19:19:26
| Melting point | 48-50 °C (lit.) |
|---|---|
| Boiling point | 179-181 °C/10 mmHg (lit.) |
| Density | 0.818 g/mL at 25 °C (lit.) |
| vapor density | 8.34 (vs air) |
| vapor pressure | <0.01 mm Hg ( 43 °C) |
| refractive index | nD79 1.4283 |
| FEMA | 2554 | 1-HEXADECANOL |
| Flash point | 275 °F |
| storage temp. | Store below +30°C. |
| solubility | Soluble in alcohol, chloroform, ether |
| form | Powder, Flakes or Pellets |
| pka | 15.20±0.10(Predicted) |
| color | White to off-white |
| Odor | at 100.00 %. waxy clean greasy floral oily |
| Odor Type | waxy |
| explosive limit | 8% |
| Water Solubility | insoluble |
| Merck | 14,2028 |
| JECFA Number | 114 |
| BRN | 1748475 |
| Dielectric constant | 3.6（60℃） |
| Stability | Stable. Incompatible with strong oxidizing agents, strong acids. |
| LogP | 6.7 |
| CAS DataBase Reference | 36653-82-4(CAS DataBase Reference) |
| NIST Chemistry Reference | 1-Hexadecanol(36653-82-4) |
| EPA Substance Registry System | 1-Hexadecanol (36653-82-4) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P280a-P304+P340-P305+P351+P338-P405-P501a | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 38-36/37/38 | |||||||||
| Safety Statements | 22-24/25-37 | |||||||||
| WGK Germany | - | |||||||||
| RTECS | MM0225000 | |||||||||
| Autoignition Temperature | 483 °F | |||||||||
| TSCA | Yes | |||||||||
| HS Code | 29051700 | |||||||||
| Toxicity | LD50 orally in Rabbit: > 2000 mg/kg LD50 dermal Rabbit > 2000 mg/kg | |||||||||
| NFPA 704 |
|
1-Hexadecanol price More Price(24)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | W255408 | 1-Hexadecanol ≥99% | 36653-82-4 | 1SAMPLE | ₹5141.88 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | W255408 | 1-Hexadecanol ≥99% | 36653-82-4 | 1KG | ₹7685.75 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | W255408 | 1-Hexadecanol ≥99% | 36653-82-4 | 10KG | ₹47662.48 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | PHR1133 | Cetyl Alcohol Pharmaceutical Secondary Standard; Certified Reference Material | 36653-82-4 | 1G | ₹8356.9 | 2022-06-14 | Buy |
| Sigma-Aldrich | 8.18704 | Cetyl alcohol for synthesis | 36653-82-4 | 100G | ₹4890 | 2022-06-14 | Buy |
1-Hexadecanol Chemical Properties,Uses,Production
Description
1-Hexadecanol is a waxy white powder or flake form at room temperature, and is insoluble in water and soluble in alcohols and oils. Discovered by Chevrenl in 1913, It is one of the oldest known long-chain alcohol. It can be produced from the reduction of palmitic acid. 1-Hexadecanol may be contained in cosmetic and personal care products such as shampoos, creams and lotions. it is mainly used as an opacifier, emulsifier, and thickening agent that alter the thickness of the liquid, and increase and stabilize the foaming capacity.
Chemical Properties
Cetyl alcohol occurs as waxy, white flakes, granules, cubes, or castings. It has a faint characteristic odor and bland taste.
Occurrence
Reported as a major constituent of spermaceti oil, where it is present chiefy as cetyl palmitate Also reported found in guava, peach, pear, kohlrabi, baked potato, mustard, Parmesan cheese, butter, milk powder, boiled egg, cooked chicken, roasted beef, beef fat, whiskies, tea, starfruit, mango, rice, licorice, kiwifruit, loquat, endive, shrimp, crab, clam, Cape gooseberry and pawpaw
Uses
1-Hexadecanol has been used in preparation of:
(±)-2-methoxyheptadecanoic acid (fatty acid)
high-chain fatty acid esters of 1-hexadecanol, novel organic phase change material for thermal energy storage
hexadecane (alkane) in the presence of membrane fraction of Vibrio furnissii M1
Production Methods
Cetyl alcohol may be manufactured by a number of methods such as esterification and hydrogenolysis of fatty acids or by catalytic hydrogenation of the triglycerides obtained from coconut oil or tallow. Cetyl alcohol may be purified by crystallization and distillation.
Definition
ChEBI: 1-Hexadecanol is a long chain fatty alcohol that is hexadecane substituted by a hydroxy group at position 1. It is a synthetic, solid, fatty alcohol and nonionic surfactant. It is used as an emulsifying agent in pharmaceutical preparations.
General Description
1-Hexadecanol is a free fatty acid alcohol generally used as an emulsifier, emollient, opacifier and surfactant in cosmetics formulations.
Safety
Cetyl alcohol is mainly used in topical formulations, although it has
also been used in oral and rectal preparations.
Cetyl alcohol has been associated with allergic delayed-type
hypersensitivity reactions in patients with stasis dermatitis. Crosssensitization
with cetostearyl alcohol, lanolin, and stearyl alcohol
has also been reported. It has been suggested that hypersensitivity
may be caused by impurities in commercial grades of cetyl
alcohol since highly refined cetyl alcohol (99.5%) has not been
associated with hypersensitivity reactions.
LD50 (mouse, IP): 1.6 g/kg
LD50 (mouse, oral): 3.2 g/kg
LD50 (rat, IP): 1.6 g/kg
LD50 (rat, oral): 5 g/kg
storage
Cetyl alcohol is stable in the presence of acids, alkalis, light, and air; it does not become rancid. It should be stored in a well-closed container in a cool, dry place.
Purification Methods
Crystallise the alcohol from aqueous EtOH or from cyclohexane. Alternatively purify it by zone refining. The purity can be checked by gas chromatography. [Beilstein 1 H 429, 1 I 219, 1 II 466, 1 III 1815, 1 IV 1876.]
Incompatibilities
Incompatible with strong oxidizing agents. Cetyl alcohol is responsible for lowering the melting point of ibuprofen, which results in sticking tendencies during the process of film coating ibuprofen crystals.
Regulatory Status
Included in the FDA Inactive Ingredients Database (ophthalmic preparations, oral capsules and tablets, otic and rectal preparations, topical aerosols, creams, emulsions, ointments and solutions, and vaginal preparations). Included in nonparenteral medicines licensed in the UK. Included in the Canadian List of Acceptable Nonmedicinal Ingredients.
1-Hexadecanol Preparation Products And Raw materials
Raw materials
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chevron_rightPreparation Products
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chevron_right| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| PERFECT CHEMICAL | +91-9820465461 +91-9820465461 | Mumbai, India | 391 | 58 | Inquiry |
| Murli Krishna Exports Pvt Ltd | +91-2225631595 +91-2225631594 | New Delhi, India | 185 | 58 | Inquiry |
| Unisynth Chemicals | +91-9820430673 +91-9820430673 | Maharashtra, India | 32 | 58 | Inquiry |
| Agilenobel | +91-8090295395 +91-8800293647 | Haryana, India | 50 | 58 | Inquiry |
| Merck Ltd | +91-2262109800 +91-2262109000 | Maharashtra, India | 272 | 58 | Inquiry |
| Godrej Industries Ltd | +919820305315 | Maharashtra, India | 41 | 58 | Inquiry |
| TRUUCHEM TECHNOLOGIES PRIVATE LIMITED | +91-8619349510 +91-8619349510 | Bangalore, India | 82 | 58 | Inquiry |
| CHEMSWORTH | +91-261-2397244 | New Delhi, India | 6707 | 30 | Inquiry |
| ALPHA CHEMIKA | +91-22-22061123 +91-22-66382501 | Mumbai, India | 1681 | 43 | Inquiry |
| Godrej Industries Limited, | 022-2518801 / 20 / 30 | New Delhi, India | 6 | 72 | Inquiry |
| Supplier | Advantage |
|---|---|
| PERFECT CHEMICAL | 58 |
| Murli Krishna Exports Pvt Ltd | 58 |
| Unisynth Chemicals | 58 |
| Agilenobel | 58 |
| Merck Ltd | 58 |
| Godrej Industries Ltd | 58 |
| TRUUCHEM TECHNOLOGIES PRIVATE LIMITED | 58 |
| CHEMSWORTH | 30 |
| ALPHA CHEMIKA | 43 |
| Godrej Industries Limited, | 72 |