Ethyl (R)-(-)-4-cyano-3-hydroxybutyate

CAS No.: 141942-85-0

Chemical Name:: Ethyl (R)-(-)-4-cyano-3-hydroxybutyate

Synonyms: ATS-5;ETHYL (S)-4-CYANO-3-HYDROXYBUTANOATE;RETINCIC ACID;Ethyl (R)-(-)-4-cyan;(R)-Ethyl 4-cyano-3-;Ats-5(For Atorvastatin);Atorvastatin Impurity 127;Atorvastatin Impurity 166;)-4-cyano-3-hydroxybutyrate;(R)-4-cyano-3-hydroxybutyric

CBNumber:: CB5188978

Molecular Formula:: C7H11NO3

Molecular Weight:: 157.17

MOL File:: 141942-85-0.mol

MSDS File:: SDS

Modify Date:: 2024/7/31 20:31:10

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Ethyl (R)-(-)-4-cyano-3-hydroxybutyate Properties

alpha	-5 º (neat)
Boiling point	270 °C(lit.)
Density	1.114 g/mL at 25 °C(lit.)
refractive index	n20/D 1.448(lit.)
Flash point	>230 °F
storage temp.	2-8°C
solubility	Chloroform (Sparingly), DMSO (Slightly), Methanol (Slightly)
form	Liquid
pka	13.03±0.20(Predicted)
color	Colorless to yellow
Specific Gravity	1.114
optical activity	[α]25/D 5°, neat
BRN	5328715
InChIKey	LOQFROBMBSKWQY-ZCFIWIBFSA-N
CAS DataBase Reference	141942-85-0(CAS DataBase Reference)

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H319

Precautionary statements

P264-P280-P305+P351+P338-P337+P313

Hazard Codes

Risk Statements

36/37/38

Safety Statements

26-36

WGK Germany

HS Code

29269090

NFPA 704

	0
2		0

Ethyl (R)-(-)-4-cyano-3-hydroxybutyate price More Price(6)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich(India)	479772	Ethyl (R)-(−)-4-cyano-3-hydroxybutyrate 95%	141942-85-0	5G	₹4470.73	2022-06-14	Buy
TCI Chemicals (India)	C1474	Ethyl (R)-(-)-4-Cyano-3-hydroxybutyrate min. 97.0 %	141942-85-0	1G	₹2300	2022-05-26	Buy
TCI Chemicals (India)	C1474	Ethyl (R)-(-)-4-Cyano-3-hydroxybutyrate min. 97.0 %	141942-85-0	5G	₹4800	2022-05-26	Buy
TCI Chemicals (India)	C1474	Ethyl (R)-(-)-4-Cyano-3-hydroxybutyrate min. 97.0 %	141942-85-0	25G	₹10800	2022-05-26	Buy
ALFA India	ALF-L19771-14	Ethyl (R)-(-)-4-cyano-3-hydroxybutyrate, 98%	141942-85-0	25g	₹10800	2022-05-26	Buy

Product number	Packaging	Price	Buy
479772	5G	₹4470.73	Buy
C1474	1G	₹2300	Buy
C1474	5G	₹4800	Buy
C1474	25G	₹10800	Buy
ALF-L19771-14	25g	₹10800	Buy

Ethyl (R)-(-)-4-cyano-3-hydroxybutyate Chemical Properties,Uses,Production

Chemical Properties

yellow liquid

Application

Hydroxyglutaryl coenzyme A (HMG-CoA) reductase inhibitors are a new class of lipid-lowering drugs, and they have a market share of more than 10 billion US dollars in the current pharmaceutical field. They can selectively inhibit the rate-limiting enzyme HMG-CoA reductase in cholesterol synthesis in the liver, reduce liver lipoprotein production, and increase the expression of low-density lipoprotein (LDL) cholesterol receptors, thereby reducing plasma cholesterol levels. They can also significantly reduce very low-density lipoprotein (VLDL) and triglycerides, and increase anti-atherosclerotic high-density protein (HDL), preventing atherosclerosis and coronary heart disease.
Ethyl (R)-(-)-4-cyano-3-hydroxybutyate is an important intermediate for the synthesis of HMG-CoA reductase inhibitors. If it is used as a raw material, synthetic atorvastatin is mainly used for the treatment of hypercholesterolemia and mixed hyperlipidemia, coronary heart disease and stroke.

Ethyl (R)-(-)-4-cyano-3-hydroxybutyate Preparation Products And Raw materials

Raw materials

Butanoic acid, 4-cyano-3-hydroxy-, (3R)- Ethyl 4-bromo-3-hydroxybutyrate Sodium cyanide Ethanol Ethyl 4-chloroacetoacetate

Preparation Products

(3R,5R)-6-Cyano-3,5-dihydroxy-hexanoic Acid tert-Butyl Ester

Ethyl (R)-(-)-4-cyano-3-hydroxybutyate Suppliers

Global( 421)Suppliers

Supplier	Tel	Country	ProdList	Advantage	Inquiry
Arch Pharmalabs Ltd	+91-2242871210 +91-2242871210	Maharashtra, India	51	58	Inquiry
Medec Dragon Private Limited	+91-9768474716	Maharashtra, India	59	58	Inquiry
TCI Chemicals (India) Pvt. Ltd.	1800 425 7889	New Delhi, India	6778	58	Inquiry
Rely Chem	08068441141Ext 305	Mumbai, India	125	58	Inquiry
Chephis Corporation	09867726678	Mumbai, India	115	58	Inquiry
Molecraft LifeSciences Pvt Ltd	+91 (91) 6018-8881	New Delhi, India	760	0	Inquiry
Carbontree (T)		Maharashtra, India	56	58	Inquiry
Unitrade Agencies	08048372548Ext 632	Mumbai, India	197	58	Inquiry
Pacific Agencies	08048372547Ext 801	Mumbai, India	135	58	Inquiry
Merix Laboratories Pvt. Ltd	91-40-27842260	Hyderabad, India	132	58	Inquiry

Supplier	Advantage
Arch Pharmalabs Ltd	58
Medec Dragon Private Limited	58
TCI Chemicals (India) Pvt. Ltd.	58
Rely Chem	58
Chephis Corporation	58
Molecraft LifeSciences Pvt Ltd	0
Carbontree (T)	58
Unitrade Agencies	58
Pacific Agencies	58
Merix Laboratories Pvt. Ltd	58

What is Ethyl (R)-(-)-4-cyano-3-hydroxybutyate?
Hydroxyglutaryl coenzyme A (HMG-CoA) reductase inhibitors are a new class of lipid-lowering drugs, and they have a market shar....
Feb 25，2020

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(R)-(-)-4-CYANO-3-HYDROXYBUTYRIC ACID ETHYL ESTER (R)-4-CYANO-3-HYDROXYBUTYRIC ACID ETHYL ESTER (R)-(-)-ETHYL 4-CYANO-3-HYDROXYBUTYRATE (R)-ETHYL 4-CYANO-3-HYDROXYBUTYRATE (S)-4-CYANO-3-HYDROXYBUTANOATE ETHYL ETHYL (3R)-4-CYANO-3-HYDROXY-BUTANOATE ETHYL (R)-4-CYANO-3-HYDROXYBUTANOATE ETHYL-(R)-(+)-4-CYANO-3-HYDROXYBUTANOATE Ethyl (R)-(-)-4-cyano-3-hydroxybutyate ETHYL (R)-(-)-4-CYANO-3-HYDROXYBUTYRATE ETHYL (R)-4-CYANO-3-HYDROXYBUTYRATE BUTANOIC ACID, 4-CYANO-3-HYDROXY-, ETHYL ESTER, (R) BUTANOIC ACID 4-CYANO-3-HYDROXY-ETHYL ESTER, (S) thyl (R)-(-)-4-Cyano-3-Hydroxy Butyate (3R)-4-cyano-3-hydroxybutyric acid ethyl ester FEthyl (R)-(-)-4-cyano-3-hydroxybutyrate Atorvastatin interMediates Ats-5 (R)-4-cyano-3-hydrobutyric acid ethyl ester Butanoic acid, 4-cyano-3-hydroxy-, ethyl ester, (3R)- (3R)-4-Cyano-3-hydroxybutanoic Acid Ethyl Ester ethyle(R)-4-cyano-3-hydroxybutanoate (R)-4-Cyano-3-hydroxy butanoate (R)-4-cyano-3-hydroxybutyric R(-)-4-cyano-3-hydroxybutyrtc ethyl ester ATS-5:(R)ETHYL-4-CYANO-3-HYCLROXY BUTANCATE R(-)4-CYANO-3-HYDROXYBUTYRIC ETHYL ESTER R(-)-4-CYANO-3-HYDROXYBUTYRTC ETHYL ESTER /ATS-5 R(-)-4-Cyano-3-hydroxubutyricethylester (R)-4-Cyano-3-hydroxybuttersureethylester (R)-4-cyano-3-hydrobutyric acid ethyl ester (R)-4-CYANO-3-HYDROXYBUTANOATE ETHYL RETINCIC ACID [R]-[-]-Ethyl-cyano-3-hydroxybutyrate (R)-(-)-4-Cyano-3-hydroxybutyratic acid, ethyl ester Ethyl (R)-4-cyano-3-hydroxybutanoate,99% Ethyl (R)-4-cyano-3-hydroxybutanoate,95% Atorvastatincalcium(R)-4-cyano-3-hydrobutyric Acid Ethyl Ester Ethyl (R)-(-)-4-cyan 4-Cyano-3-hydroxy-butyric acid ethyl ester )-4-cyano-3-hydroxybutyrate Ethyl-(R)-4-(-)-cyano-3-hydroxybutyrate(C-1) (R)-Ethyl 4-cyano-3- Ethyl (R)-(-)-4-cyano-3-hydroxybutyrate[141942-85-0] Ats-5(For Atorvastatin) Ethyl (R)-(-)-4-Cyano-3-hydroxybutyrate > (R)-(-)-4-Cyano-3-hydroxybutyrate Atorvastatin Impurity 127 (3R)-4-Cyano-3-hydroxybutanoic Acid Ethyl (R)-(-)-4-CYANO-3-HYDROXYBUTYATE (3R)-4-Cyano-3-hydroxybutyric Acid Ethyl EsterQ: What is (3R)-4-Cyano-3-hydroxybutyric Acid Ethyl Ester Q: What is the CAS Number of (3R)-4-Cyano-3-hydroxybutyric Acid Ethyl Ester Q: What is the storage condition of (3R)-4-Cyano-3-hydroxybutyric Acid Ethyl Ester ETHYL (S)-4-CYANO-3-HYDROXYBUTANOATE ATS-5 Ethyl (R)-(-)-4-cyano-3-hydroxybutyrate(ATS-5) Atorvastatin calcium impurity 63 Atorvastatin Impurity 166 ethyl (R)-3-hydroxy-4-cyano-butyrate 141942-85-0 41942-85-0 NCCH2CHOHCH2CO2C2H5