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Ledipasvir

CAS No.: 1256388-51-8

Chemical Name:: Ledipasvir

Synonyms: GS 588;GS5885;CS-948;GS 5885;GS-5885;Ledipasvir;Leidipawei;332382-54-7;gs-5885/gs5885;Ledipasvir API

CBNumber:: CB52666650

Molecular Formula:: C49H54F2N8O6

Molecular Weight:: 889

MOL File:: 1256388-51-8.mol

Modify Date:: 2024/3/28 13:39:29

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Ledipasvir Properties

Melting point	186-190oC
Density	1.42±0.1 g/cm3(Predicted)
storage temp.	-20°C Freezer
solubility	DMSO (Slightly, Heated), Methanol (Slightly)
pka	11.20±0.10(Predicted)
form	Solid
color	White to Pale Beige

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H302-H315-H319-H335
Precautionary statements	P261-P305+P351+P338
Safety Statements	24/25
RIDADR	3077
HS Code	29333990

Ledipasvir Chemical Properties,Uses,Production

Description

Ledipasvir is a potent NS5A inhibitor that is approved for use in combination with sofosbuvir, a nucleotide inhibitor of viral polymerase, for the treatment of chronic hepatitis C virus genotype 1 infection. This combination was discovered and developed at Gilead Sciences and is marketed as the fixed combination with brand name of Harvoni.

Uses

Ledipasvir is most commonly used in combination with sofosbuvir for treatment in chronic hepatitis C genotype 1 patients. It inhibits an important viral phosphoprotein, NS5A, which is involved in viral replication, assembly, and secretion.

Definition

ChEBI: Ledipasvir is a benzimidazole derivative that is used in combination with sofosbuvir (under the trade name Harvoni) for the treatment of chronic hepatitis C genotype 1 infection. It has a role as an antiviral drug and a hepatitis C protease inhibitor. It is a carbamate ester, a L-valine derivative, a bridged compound, a carboxamide, a benzimidazole, a member of fluorenes, an organofluorine compound, a member of imidazoles, a N-acylpyrrolidine and an azaspiro compound.

Mode of action

Ledipasvir is a potent inhibitor of HCV nonstructural protein 5A (NS5A), a viral phosphoprotein that plays an important but poorly understood role in viral replication, assembly, and secretion. ;Ledipasvir is approved for the treatment of genotype 1 HCV. Its safety and efficacy have not been fully established for genotypes 2 through 6. NS5A amino acid substitutions Y93H (in genotypes 1a and 1b) and Q30E (in genotype 1a) significantly reduce susceptibility to ledipasvir in cell culture and in clinical studies. Other amino acid substitutions observed in virologic treatment failures are K24R, M28T/V, Q30H/K/L (genotype 1a), and L31V/M/I (genotype 1b). Viruses with these resistance-associated mutations remained susceptible to sofosbuvir.

Ledipasvir Preparation Products And Raw materials

Raw materials

Carbamic acid, N-[(1S)-2-methyl-1-[[(1R,3S,4S)-3-[6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-benzimidazol-2-yl]-2-azabicyclo[2.2.1]hept-2-yl]carbonyl]propyl]-, methyl ester 1,2-Pyrrolidinedicarboxylicacid,1-methylester,(2S)-(9CI) ledipasvir interMediate ledipasvir interMediate Valine, N-(methoxycarbonyl)-

Preparation Products

Ledipasvir Suppliers

Global( 268)Suppliers

Supplier	Tel	Country	ProdList	Advantage	Inquiry
Jigs Chemical ltd	+919099003427	Gujarat, India	239	58	Inquiry
Lupin Ltd	+91-8019896181 +91-8019896181	Maharashtra, India	93	58	Inquiry
VIVIN DRUGS AND PHARMACEUTICALS LTD	+91-22670456625 +91-224067045635	Telangana, India	22	58	Inquiry
NATCO Pharma Limited	+91-9849511345 +91-9866005199	Hyderabad, India	24	58	Inquiry
Humble Healthcare Limited	+91-9720093000 +91-8006400378	Uttar Pradesh, India	141	58	Inquiry
BDR Pharmaceuticals International Pvt Ltd	+91-2240560560 +91-7718884418	Maharashtra, India	206	58	Inquiry
Mylan Laboratories Ltd	+91-4023550543 +91-4030866666	Telangana, India	150	58	Inquiry
LUPIN LTD	+91 124 4885000 / +91 124 3325000	New Delhi, India	191	58	Inquiry
A.J Chemicals	91-9810153283	New Delhi, India	6124	58	Inquiry
CLEARSYNTH LABS LTD.	+91-22-45045900	Hyderabad, India	6351	58	Inquiry

Supplier	Advantage
Jigs Chemical ltd	58
Lupin Ltd	58
VIVIN DRUGS AND PHARMACEUTICALS LTD	58
NATCO Pharma Limited	58
Humble Healthcare Limited	58
BDR Pharmaceuticals International Pvt Ltd	58
Mylan Laboratories Ltd	58
LUPIN LTD	58
A.J Chemicals	58
CLEARSYNTH LABS LTD.	58

Ledipasvir Spectrum

Ledipasvir(1256388-51-8)¹HNMR

1256388-51-8(Ledipasvir)Related Search:

2-BROMOCARBAZOLE ILOPERIDONE ledipasvir interMediate Alogliptin benzoate Triphenylphosphine oxide

Tenofovir Daptomycin Velpatasvir Donepezil Hydrochloride Y27632 (hydrochloride)

Daclatasvir VX-809 Veliparib Benoxinate Hydrochloride Sofosbuvir

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GS 5885 GS5885 GS-5885 Ledipasvir GS-5885/Ledipasvir gs-5885/gs5885 Ledipasvir / GS 5885 GS 588 HY-15602 (GS-5885 Solid dispersion of ledipasvir Ledipasvir (API, Amorphous) Ledipasvir: copovidone solid dispersion 1:1 N-[(1S)-1-[[(6S)-6-[5-[9,9-difluoro-7-[2-[(1R,3S,4S)-2-[(2S)-2-[(methoxycarbonyl)amino]-3-methyl-1-oxobutyl]-2-azabicyclo[2.2.1]hept-3-yl]-1H-benzimidazol-6-yl]-9H-fluoren-2-yl]-1H-imidazol-2-yl]-5-azaspiro[2.4]hept-5-yl]carbonyl]-2-methylpropyl]-carbamic acid methyl ester Leidipawei N-[(1S)-1-[[(6S)-6-[5-[9,9-difluoro-7-[2-[(1R,3S,4S)-2-[(2S)-2-[(methoxycarbonyl)amino]-3-methyl-1-oxoButyl]-2-azabicyclo[2.2.1]hept-3-yl]-1H-benzimidazol-6-yl]-9H-fluoren-2-yl]-1H-imidazol-2-yl]-5-azaspiro[2.4]hept-5-yl]carbonyl]-2-methylpropyl]-carbamic Ledipasvir API N-[(1S)-1-[[(6S)-6-[5-[9,9-Difluoro-7-[2-[(1R,3S,4S)-2-[(2S)-2-[(methoxycarbonyl)amino]-3-methyl-1-oxobutyl]-2-azabicyclo[2.2.1]hept-3-yl]-1H-benzimidazol-6-yl]-9H-fluoren-2-yl]-1H-imidazol-2-yl]-5-azaspi Ledipasvir, 98%, HCV NS5A polymerase inhibitor GS 5885;GS-5885;GS5885 CS-948 Carbamic acid, N-[(1S)-1-[[(6S)-6-[5-[9,9-difluoro-7-[2-[(1R,3S,4S)-2-[(2S)-2-[(methoxycarbonyl)amino]-3-methyl-1-oxobutyl]-2-azabicyclo[2.2.1]hept-3-yl]-1H-benzimidazol-6-yl]-9H-fluoren-2-yl]-1H-imidazol-2-yl]-5-azaspiro[2.4]hept-5-yl]carbonyl]-2-methylpropyl]-, methyl ester Ledipasvir (10mM in DMSO) methyl((S)-1-((S)-6-(5-(9,9-difluoro-7-(2-((1R,3S,4S)-2-((methoxycarbonyl)-L-valyl)-2-azabicyclo[2.2.1]heptan-3-yl)-1H-benzo[d]imidazol-6-yl)-9H-fluoren-2-yl)-1H-imidazol-2-yl)-5-azaspiro[2.4]heptan-5-yl)-3-methyl-1-oxobutan-2-yl)carbamate Ledipasvir 13C2 D6Q: What is Ledipasvir 13C2 D6 Q: What is the CAS Number of Ledipasvir 13C2 D6 Q: What is the storage condition of Ledipasvir 13C2 D6 Q: What are the applications of Ledipasvir 13C2 D6 Ledipasvir D16 Ledipasvir D8Q: What is Ledipasvir D8 Q: What is the CAS Number of Ledipasvir D8 Q: What is the storage condition of Ledipasvir D8 Q: What are the applications of Ledipasvir D8 LedipasvirQ: What is Ledipasvir Q: What is the CAS Number of Ledipasvir Q: What is the storage condition of Ledipasvir Q: What are the applications of Ledipasvir 332382-54-7 1H-Pyrazol-5-amine,1-(6-methylethyl)- Ledipasvir undefined salt form 1256388-51-8 256388-51-8 C49H54F2N8O6 Inhibitors API