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TG003

TG003 Structure
CAS No.
300801-52-9
Chemical Name:
TG003
Synonyms
CS-955;CS-1704;(E/Z)-TG003;TG003/TG-003;TG003 USP/EP/BP;Cdc2-Like Kinase Inhibitor, TG003;1-(3-Ethyl-5-methoxy-2(3H)-benzothiazolylidene)-2-propanone;2-Propanone,1-(3-ethyl-5-Methoxy-2(3H)-benzothiazolylidene)-;1-(3-Ethyl-5-methoxybenzo[d]thiazol-2(3H)-ylidene)propan-2-one;(1Z)-1-(3-Ethyl-5-methoxy-1,3-benzothiazol-2-ylidene)propan-2-one
CBNumber:
CB5505045
Molecular Formula:
C13H15NO2S
Molecular Weight:
249.33
MOL File:
300801-52-9.mol
Modify Date:
2023/6/8 9:01:58
Request For Quotation

TG003 Properties

Melting point 132-132.5 °C
Boiling point 386.0±42.0 °C(Predicted)
Density 1.237±0.06 g/cm3(Predicted)
storage temp. 2-8°C
solubility DMSO: 33 mg/mL
form solid
pka -1.76±0.20(Predicted)
color pale yellow
Sensitive Light Sensitive

SAFETY

Risk and Safety Statements

Symbol(GHS) 
GHS07
Signal word  Warning
Hazard statements  H315-H319-H335
Precautionary statements  P261-P280a-P304+P340-P305+P351+P338-P405-P501a
Hazard Codes  Xi
Risk Statements  36/37/38
Safety Statements  26-36
WGK Germany  3
NFPA 704
0
2 0

TG003 price More Price(2)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich(India) T5575 TG003 ≥98% (HPLC) 300801-52-9 5MG ₹17190.1 2022-06-14 Buy
Sigma-Aldrich(India) T5575 TG003 ≥98% (HPLC) 300801-52-9 25MG ₹75179.63 2022-06-14 Buy
Product number Packaging Price Buy
T5575 5MG ₹17190.1 Buy
T5575 25MG ₹75179.63 Buy

TG003 Chemical Properties,Uses,Production

Description

Cdc2-like kinase (Clk), among a number of other kinases, phosphorylates serine/arginine-rich proteins which play a role in alternative splicing of pre-mRNA. The Clk family consists of four members, which include Clk1/Sty and Clk2-4. TG003 is a novel benzothiazole compound that demonstrates potent inhibition of Clk1/Sty and Clk4 with IC50 values of 20 and 15 nM, respectively. TG003 exhibits considerably weaker inhibition of Clk2 and Clk3 (IC50 = 200 nM and >10 μM, respectively). Through suppression of Clk-mediated phosphorylation, TG003 inhibits SF2/ASF-dependent splicing of β-globin pre-mRNA at 1 μM in vitro. At 10 μM, TG003 rescues the embryonic defects induced by excessive Clk activity in Xenopus.

Uses

TG003 can be used as a potent CDC-2 kinase inhibitor, allowing for research into identification of signaling pathways and possible therapeutic treatments.

Biochem/physiol Actions

TG003, a CLK (cdc2-like kinase) family inhibitor is used as a drug for duchenne muscular dystrophy.

TG003 Preparation Products And Raw materials

Raw materials

Preparation Products

TG003 Suppliers

Global( 74)Suppliers
Supplier Tel Country ProdList Advantage Inquiry
A.J Chemicals 91-9810153283 New Delhi, India 6124 58 Inquiry
CLEARSYNTH LABS LTD. +91-22-45045900 Hyderabad, India 6351 58 Inquiry
ATK CHEMICAL COMPANY LIMITED +undefined-21-51877795 China 32760 60 Inquiry
TargetMol Chemicals Inc. +1-781-999-5354 +1-00000000000 United States 19892 58 Inquiry
Dideu Industries Group Limited +86-29-89586680 +86-15129568250 China 26368 58 Inquiry
Zhejiang J&C Biological Technology Co.,Limited +1-2135480471 +1-2135480471 China 10522 58 Inquiry
Wuhan Topule Biopharmaceutical Co., Ltd +8618327326525 China 8474 58 Inquiry
LEAPCHEM CO., LTD. +86-852-30606658 China 43348 58 Inquiry
Aladdin Scientific +1-+1(833)-552-7181 United States 57511 58 Inquiry
Amadis Chemical Company Limited 571-89925085 China 131980 58 Inquiry
Supplier Advantage
A.J Chemicals 58
CLEARSYNTH LABS LTD. 58
ATK CHEMICAL COMPANY LIMITED 60
TargetMol Chemicals Inc. 58
Dideu Industries Group Limited 58
Zhejiang J&C Biological Technology Co.,Limited 58
Wuhan Topule Biopharmaceutical Co., Ltd 58
LEAPCHEM CO., LTD. 58
Aladdin Scientific 58
Amadis Chemical Company Limited 58

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Cdc2-Like Kinase Inhibitor, TG003 TG003/TG-003 2-Propanone,1-(3-ethyl-5-Methoxy-2(3H)-benzothiazolylidene)- (1Z)-1-(3-Ethyl-5-methoxy-1,3-benzothiazol-2-ylidene)propan-2-one 1-(3-Ethyl-5-methoxy-2(3H)-benzothiazolylidene)-2-propanone (Z)-1-(3-ethyl-5-methoxybenzo[d]thiazol-2(3H)-ylidene)propan-2-one CS-955 CS-1704 1-(3-Ethyl-5-methoxybenzo[d]thiazol-2(3H)-ylidene)propan-2-one TG003 USP/EP/BP (E/Z)-TG003 (E/Z) TG003,Cyclin dependent kinase,site,tumor,(E/Z)-TG003,Wilm's,(E/Z)-TG-003,splice,inhibit,mutation,Inhibitor,CDK,cancer,(E/Z)TG003,breast 300801-52-9 Inhibitors