TG003
- ₹17190.1 - ₹75179.63
- Product name: TG003
- CAS: 300801-52-9
- MF: C13H15NO2S
- MW: 249.33
- EINECS:
- MDL Number:MFCD00624584
- Synonyms:Cdc2-Like Kinase Inhibitor, TG003;TG003/TG-003;2-Propanone,1-(3-ethyl-5-Methoxy-2(3H)-benzothiazolylidene)-;(1Z)-1-(3-Ethyl-5-methoxy-1,3-benzothiazol-2-ylidene)propan-2-one;1-(3-Ethyl-5-methoxy-2(3H)-benzothiazolylidene)-2-propanone;(Z)-1-(3-ethyl-5-methoxybenzo[d]thiazol-2(3H)-ylidene)propan-2-one;CS-955;CS-1704
2 prices
Selected condition:
Brand
- Sigma-Aldrich(India)
Package
- 5MG
- 25MG
- ManufacturerSigma-Aldrich(India)
- Product numberT5575
- Product descriptionTG003 ≥98% (HPLC)
- Packaging5MG
- Price₹17190.1
- Updated2022-06-14
- Buy
- ManufacturerSigma-Aldrich(India)
- Product numberT5575
- Product descriptionTG003 ≥98% (HPLC)
- Packaging25MG
- Price₹75179.63
- Updated2022-06-14
- Buy
Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|
Sigma-Aldrich(India) | T5575 | TG003 ≥98% (HPLC) | 5MG | ₹17190.1 | 2022-06-14 | Buy |
Sigma-Aldrich(India) | T5575 | TG003 ≥98% (HPLC) | 25MG | ₹75179.63 | 2022-06-14 | Buy |
Properties
Melting point :132-132.5 °C
Boiling point :386.0±42.0 °C(Predicted)
Density :1.237±0.06 g/cm3(Predicted)
storage temp. :2-8°C
solubility :DMSO: 33 mg/mL
form :solid
pka :-1.76±0.20(Predicted)
color :pale yellow
Sensitive :Light Sensitive
Boiling point :386.0±42.0 °C(Predicted)
Density :1.237±0.06 g/cm3(Predicted)
storage temp. :2-8°C
solubility :DMSO: 33 mg/mL
form :solid
pka :-1.76±0.20(Predicted)
color :pale yellow
Sensitive :Light Sensitive
Safety Information
Symbol(GHS): | |||||||||||||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Signal word: | Warning | ||||||||||||||||||||||||||||
Hazard statements: |
|
||||||||||||||||||||||||||||
Precautionary statements: |
|
Description
Cdc2-like kinase (Clk), among a number of other kinases, phosphorylates serine/arginine-rich proteins which play a role in alternative splicing of pre-mRNA. The Clk family consists of four members, which include Clk1/Sty and Clk2-4. TG003 is a novel benzothiazole compound that demonstrates potent inhibition of Clk1/Sty and Clk4 with IC50 values of 20 and 15 nM, respectively. TG003 exhibits considerably weaker inhibition of Clk2 and Clk3 (IC50 = 200 nM and >10 μM, respectively). Through suppression of Clk-mediated phosphorylation, TG003 inhibits SF2/ASF-dependent splicing of β-globin pre-mRNA at 1 μM in vitro. At 10 μM, TG003 rescues the embryonic defects induced by excessive Clk activity in Xenopus.More related product prices
918504-65-1 Vorinostat PD 0325901 1232410-49-9 ML167 Y27632 (hydrochloride) DiethylzincRelated product price
- Vorinostat
₹10110.55-40983.45 - PD 0325901
₹15891.1-60457.63 - 1232410-49-9
₹11431.2-46547.5