Pramoxine hydrochloride
- CAS No.
- 637-58-1
- Chemical Name:
- Pramoxine hydrochloride
- Synonyms
- PRAMOXINE HCL;PRAMOXINE HCL USP;proctofoam;Pramoxine HCI;Pramocaine HCl;PraMoxine HCL API;Pramoxine Hcl USP38;PRAMOXINE HYDROCHLORIDE;PRAXOMINE HYDROCHLORIDE;Pumocaine hydrochloride
- CBNumber:
- CB5675186
- Molecular Formula:
- C17H28ClNO3
- Molecular Weight:
- 329.86
- MOL File:
- 637-58-1.mol
- MSDS File:
- SDS
- Modify Date:
- 2024/7/2 8:55:11
| Melting point | 181-183° |
|---|---|
| storage temp. | Inert atmosphere,Room Temperature |
| solubility | Chloroform (Slightly), Methanol (Slightly) |
| form | Solid |
| color | White to Off-White |
| Stability | Hygroscopic |
| InChI | InChI=1S/C17H27NO3.ClH/c1-2-3-12-20-16-5-7-17(8-6-16)21-13-4-9-18-10-14-19-15-11-18;/h5-8H,2-4,9-15H2,1H3;1H |
| InChIKey | SYCBXBCPLUFJID-UHFFFAOYSA-N |
| SMILES | C1(OCCCN2CCOCC2)=CC=C(OCCCC)C=C1.Cl |
| LogP | 3.477 (est) |
| CAS DataBase Reference | 637-58-1(CAS DataBase Reference) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302-H315-H319-H335 | |||||||||
| Precautionary statements | P261-P264-P270-P301+P312-P302+P352-P305+P351+P338 | |||||||||
| Hazard Codes | Xi,Xn | |||||||||
| Risk Statements | 22-36/37/38 | |||||||||
| Safety Statements | 26-36 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | QD8750000 | |||||||||
| HS Code | 2934990002 | |||||||||
| Toxicity | LD50 i.v. in mice: 79.5 ±2.7 mg/kg (Schmidt); LD50 in mice (mg/kg): 300 i.p., 750 s.c. (Monash, Gibbs) | |||||||||
| NFPA 704 |
|
Pramoxine hydrochloride price More Price(3)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | P9422 | Pramoxine hydrochloride analytical standard, ≥98% | 637-58-1 | 10G | ₹6191.9 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | PHR1302 | Pramoxine hydrochloride Pharmaceutical Secondary Standard; Certified Reference Material | 637-58-1 | 1G | ₹8443.5 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | P9422 | Pramoxine hydrochloride analytical standard, ≥98% | 637-58-1 | 25G | ₹12156.48 | 2022-06-14 | Buy |
Pramoxine hydrochloride Chemical Properties,Uses,Production
Description
Pramoxine, also known as pramocaine, is different from other local anesthetic compounds in chemical structure. Active groups which are carboxylic acid derivatives like ester and amide are not present in this molecule. The drug molecule consists of ether functional groups that are much less active on a chemical level. The presence of the free radical morpholine in this compound is the cause of the reduction of the factor of toxicity and pharmacological activity. In pramoxine, toxicity is reduced but the local anesthetic affect is maintained.
Uses
Pramoxine Hydrochloride is used as a local anaesthetic and often in anti-itch formulations that provides temporary relief from itching caused by insect bites, minor skin irritations, poison ivy, sunburn and more.
Indications
Pramoxine hydrochloride (Itch-X, PrameGel, Prax, Tronothane, AmLactin AP) is a local anesthetic that is structurally similar to dyclonine and unrelated to the esteror amide-type compounds.Apply to affected area t.i.d. to q.i.d., as directed by a physician. Useful for patients sensitive to ester and/or amide anesthetics. Onset of anesthesia is within minutes. Duration of anesthesia is 2 to 4 hours.
Clinical Use
Pramoxine is an amino-ether which, like dyclonine, is used as a topical agent in the form of its hydrochloride. Pramoxine hydrochloride may be used for anaesthesia of minor skin wounds and the relief of haemomhoids and other anorectal disorders.The drug is an ingredient of many proprietary topical products, and the U.S.P. has official cream and gel formulations.
Mode of action
Pramoxine hydrochloride is the hydrochloride salt form of pramoxine, a morpholine derivative with local anesthetic property. Pramocaine hydrochloride decreases the permeability of the neuronal membrane to sodium ions by reversibly binding to and inhibiting voltage-gated sodium channels. This results in stabilization of the membrane and, thereby inhibiting the ionic fluxes required for membrane depolarization, hence resulting in the failure to initiate a propagated action potential and subsequent conduction blockade.
Pramoxine hydrochloride Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| RESONANCE LABS | +91-8027630180 +91-8027630180 | Karnataka, India | 32 | 58 | Inquiry |
| Ar Ex Laboratories Pvt Ltd | 91-22-24454109 | Maharashtra, India | 18 | 58 | Inquiry |
| Ralington Pharma | +91-7948911722 +91-9687771722 | Gujarat, India | 1350 | 58 | Inquiry |
| Flowchem Pharma Pvt Ltd | +91-9606036218 +91-9845055636 | Karnataka, India | 33 | 58 | Inquiry |
| Bioxera Pharma Pvt. Ltd. | +91-2261842739 +91-2266862739 | Maharashtra, India | 20 | 58 | Inquiry |
| CLEARSYNTH LABS LTD. | +91-22-45045900 | Hyderabad, India | 6351 | 58 | Inquiry |
| A.J Chemicals | 91-9810153283 | New Delhi, India | 6124 | 58 | Inquiry |
| Pharmaffiliates Analytics and Synthetics P. Ltd | +91-172-5066494 | Haryana, India | 6773 | 58 | Inquiry |
| Bioxera Pharma Pvt. Ltd | 08048250473Ext 736 | Mumbai, India | 8 | 58 | Inquiry |
| Resonance Laboratories Private Limited | 08066085747Ext 283 | Karnataka, India | 13 | 58 | Inquiry |
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