Palonosetron Hydrochloride
- CAS No.
- 135729-62-3
- Chemical Name:
- Palonosetron Hydrochloride
- Synonyms
- PALONOSETRON HCL;Aloxi;Palonosetron HCI;Onicit;CS-292;RS 25259;RS-25259-197;PalnosetronHcl;a 5-HT3 antagonist;Palonosetron-d3 HCl
- CBNumber:
- CB0210849
- Molecular Formula:
- C19H25ClN2O
- Molecular Weight:
- 332.87
- MOL File:
- 135729-62-3.mol
- MSDS File:
- SDS
- Modify Date:
- 2024/5/23 13:57:25
| Melting point | >290°C |
|---|---|
| alpha | D25 -94.1° (c = 0.4 in water) |
| storage temp. | Inert atmosphere,Store in freezer, under -20°C |
| solubility | Methanol (Slightly, Heated), Water (Slightly) |
| form | Solid |
| color | White to Off-White |
| Merck | 14,6997 |
| InChI | InChI=1/C19H24N2O.ClH/c22-19-16-6-2-4-14-3-1-5-15(18(14)16)11-21(19)17-12-20-9-7-13(17)8-10-20;/h2,4,6,13,15,17H,1,3,5,7-12H2;1H/t15-,17-;/s3 |
| InChIKey | OLDRWYVIKMSFFB-HYCRUXCXNA-N |
| SMILES | N1(C[C@@]2([H])CCCC3=CC=CC(=C32)C1=O)[C@H]1[C@]2([H])CCN(CC2)C1.Cl |&1:2,15,16,r| |
| CAS DataBase Reference | 135729-62-3(CAS DataBase Reference) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H332-H302-H312 |
| Precautionary statements | P264-P270-P301+P312-P330-P501-P280-P302+P352-P312-P322-P363-P501-P261-P271-P304+P340-P312 |
| HS Code | 29339900 |
Palonosetron Hydrochloride price More Price(2)
Palonosetron Hydrochloride Chemical Properties,Uses,Production
Description
Palonosetron is a novel 5-HT3 receptor antagonist launched as an injectable agent for the prevention of acute and delayed nausea and vomiting associated with cancer chemotherapy. It has a much longer half-life (～ 40 h) than the other currently available 5-HT3 antagonists, which provides efficacy advantages in the prevention of delayed nausea and vomiting that typically occurs after 24 h and up to six days post chemotherapy administration. Palonosetron was developed as a conformationally restricted analog of the previously known 5HT3 antagonists tropisetron and granisetron. It is synthesized in four steps starting with the condensation of 1,8- naphthalic anhydride and (S)-3-aminoquinuclidine to produce the corresponding imide. The subsequent steps include catalytic hydrogenation of one of the aromatic rings of the imide intermediate, selective reduction of one of the carbonyls to a hydroxyl group, dehydration to an olefin and catalytic hydrogenation. The recommended dosage of palonosteron is 0.25 mg, administered as a single intravenous dose approximately 30 min before the start of chemotherapy. Palonosetron exhibits dose-proportional pharmacokinetics and it is moderately bound to plasma proteins (62%). Fifty percent of the dose is metabolized in the liver, and 40% is excreted unchanged in the urine. In comparative clinical studies with two other 5- HT3 receptor antagonists, palonosetron is shown to be as effective as dolasetron and more effective than ondansetron in controlling acute nausea and vomiting and superior to both in the control of delayed nausea and vomiting. Efficacy of palonosetron has been demonstrated in patients receiving initial and repeat courses of both moderately and highly emetogenic chemotherapy, including cisplatin, cyclophosphamide and dacarbazine. At 0.25 and 0.75 mg doses, palonosetron is well tolerated and the most occurring adverse events are headache, diarrhea, fatigue, abdominal pain and insomnia.
Chemical Properties
White Solid
Uses
(S,S)-Palonosetron Hydrochloride is a serotonin 5-HT3 receptor antagonist used in the prevention and treatment of chemotherapy-induced nausea and vomiting (CINV). Antiemetic.
Definition
ChEBI: A hydrochloride obtained by combining palonosetron with one molar equivalent of hydrogen chloride; an antiemetic used in combination with netupitant (under the trade name Akynzeo) to treat nausea and vomiting in patients undergoing cancer chemotherapy.
Palonosetron Hydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| Dr. Reddy's Laboratories Ltd | +91-4049002900 +91-4049002900 | Hyderabad, India | 165 | 58 | Inquiry |
| Aurobindo Pharma Limited | +914066725000 | Telangana, India | 112 | 58 | Inquiry |
| Cipla Ltd | +912224826000 | Maharashtra, India | 133 | 58 | Inquiry |
| Raising Sun Pharma | +91-9399941155 +91-9399941155 | Telangana, India | 127 | 58 | Inquiry |
| Ralington Pharma | +91-7948911722 +91-9687771722 | Gujarat, India | 1350 | 58 | Inquiry |
| Century Pharmaceuticals Ltd | +91-2652361581 +91-2652361581 | Gujarat, India | 53 | 58 | Inquiry |
| WOCKHARDT BIO AG | New Delhi, India | 8 | 58 | Inquiry | |
| AUROBINDO PHARMA LTD | +91 (40) 6672 1200 | New Delhi, India | 209 | 58 | Inquiry |
| TYCHE INDUSTRIES LTD | +91 40 2354 1688 | New Delhi, India | 2 | 58 | Inquiry |
| EMCURE PHARMACEUTICALS LTD | +91 22 3061 0000 | New Delhi, India | 93 | 58 | Inquiry |
| Supplier | Advantage |
|---|---|
| Dr. Reddy's Laboratories Ltd | 58 |
| Aurobindo Pharma Limited | 58 |
| Cipla Ltd | 58 |
| Raising Sun Pharma | 58 |
| Ralington Pharma | 58 |
| Century Pharmaceuticals Ltd | 58 |
| WOCKHARDT BIO AG | 58 |
| AUROBINDO PHARMA LTD | 58 |
| TYCHE INDUSTRIES LTD | 58 |
| EMCURE PHARMACEUTICALS LTD | 58 |
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