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ChemicalBook > Product Catalogue >Biochemical Engineering >Inhibitors >Neuronal Signaling >5-HT Receptor Antagonists >Palonosetron Hydrochloride

Palonosetron Hydrochloride

Palonosetron Hydrochloride Structure
  • ₹11000 - ₹32500
  • Product name: Palonosetron Hydrochloride
  • CAS: 135729-62-3
  • MF: C19H25ClN2O
  • MW: 332.87
  • EINECS:680-630-6
  • MDL Number:MFCD07370072
  • Synonyms:PALONOSETRON HYDROCHLORIDE;(3aS)-2-(3S)-1-Azabicyclo[2.2.2]oct-3-yl-2,3,3a,4,5,6-hexahydro-1H-benz[de]isoquinolin-1-one Hydrochloride;Onicit;RS-25259-197;(3aS)-2-(3S)-1-Azabicyclo[2.2.2]oct-3-yl-2,3,3a,4,5,6-hexahydro-1H-benz[de]isoquinolin-1-one monohydrochloride;(S,S)-Palonosetron Hydrochloride;(S,S)-Palonosetron HCl;(3aS)-2-[(S)-1-Azabicyclo[2.2.2]oct-3-yl]-2,3,3a,4,5,6-hexahydro-1-oxo-1H-benz[de]isoquinoline hydrochloride
2 prices
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Brand

  • TCI Chemicals (India)

Package

  • 200MG
  • 1G
  • ManufacturerTCI Chemicals (India)
  • Product numberP2051
  • Product descriptionPalonosetron Hydrochloride
  • Packaging200MG
  • Price₹11000
  • Updated2022-05-26
  • Buy
  • ManufacturerTCI Chemicals (India)
  • Product numberP2051
  • Product descriptionPalonosetron Hydrochloride
  • Packaging1G
  • Price₹32500
  • Updated2022-05-26
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
TCI Chemicals (India) P2051 Palonosetron Hydrochloride 200MG ₹11000 2022-05-26 Buy
TCI Chemicals (India) P2051 Palonosetron Hydrochloride 1G ₹32500 2022-05-26 Buy

Properties

Melting point :>290°C
alpha :D25 -94.1° (c = 0.4 in water)
storage temp. :Inert atmosphere,Store in freezer, under -20°C
solubility :Methanol (Slightly, Heated), Water (Slightly)
form :Solid
color :White to Off-White
Merck :14,6997
InChI :InChI=1/C19H24N2O.ClH/c22-19-16-6-2-4-14-3-1-5-15(18(14)16)11-21(19)17-12-20-9-7-13(17)8-10-20;/h2,4,6,13,15,17H,1,3,5,7-12H2;1H/t15-,17-;/s3
InChIKey :OLDRWYVIKMSFFB-HYCRUXCXNA-N
SMILES :N1(C[C@@]2([H])CCCC3=CC=CC(=C32)C1=O)[C@H]1[C@]2([H])CCN(CC2)C1.Cl |&1:2,15,16,r|
CAS DataBase Reference :135729-62-3(CAS DataBase Reference)

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning GHS hazard pictograms P264, P270, P301+P312, P330, P501
H312 Harmful in contact with skin Acute toxicity,dermal Category 4 Warning GHS hazard pictograms P280,P302+P352, P312, P322, P363,P501
H332 Harmful if inhaled Acute toxicity,inhalation Category 4 Warning GHS hazard pictograms P261, P271, P304+P340, P312
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P264 Wash hands thoroughly after handling.
P264 Wash skin thouroughly after handling.
P270 Do not eat, drink or smoke when using this product.
P271 Use only outdoors or in a well-ventilated area.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312 IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352 IF ON SKIN: wash with plenty of soap and water.
P304+P340 IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P312 Call a POISON CENTER or doctor/physician if you feel unwell.
P322 Specific measures (see …on this label).
P330 Rinse mouth.
P363 Wash contaminated clothing before reuse.
P501 Dispose of contents/container to..…

Description

Palonosetron is a potent, selective antagonist of the serotonin (5-HT) receptor 5-HT3 (pKi = 10.4 in rat cortex) that minimally effects a wide range of other neuronal receptors. It is orally bioavailable and potently inhibits emesis induced by chemotherapeutic drugs, like cisplatin , but not by apomorphine , which acts by dopamine receptor antagonism. Palonosetron is remarkable for its long duration of action, related to its high receptor-binding affinity and long half-life. It is effective in managing chemotherapy-induced nausea and vomiting.

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