Ramatroban

CAS No.: 116649-85-5

Chemical Name:: Ramatroban

Synonyms: Baynas;CS-1350;BAY-U3405;RAMATROBAN;RaMantroban;Ray ma music class;BAY U3405; BAY-U3405;RaMatroban(BAY-u3405);Ramatroban for research;RAFFINOSE UNDECAACETATE, D-(+)-(RG)

CBNumber:: CB5735921

Molecular Formula:: C21H21FN2O4S

Molecular Weight:: 416.47

MOL File:: 116649-85-5.mol

Modify Date:: 2023/9/4 15:50:00

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Ramatroban Properties

Melting point	134-135°
alpha	D +70.1° (c = 1.0 in methanol)
Boiling point	654.7±65.0 °C(Predicted)
Density	1.43±0.1 g/cm3(Predicted)
storage temp.	Sealed in dry,2-8°C
solubility	DMSO: ≥40mg/mL
form	solid
pka	4.60±0.10(Predicted)
color	white
CAS DataBase Reference	116649-85-5(CAS DataBase Reference)

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H315-H319-H335

Precautionary statements

P261-P264-P271-P280-P302+P352-P305+P351+P338

Hazard Codes

Risk Statements

36/37/38

Safety Statements

26-36/37/39-45

WGK Germany

NFPA 704

	0
2		0

Ramatroban price More Price(2)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich(India)	R0531	Ramatroban ≥98% (HPLC), solid	116649-85-5	5MG	₹16908.65	2022-06-14	Buy
Sigma-Aldrich(India)	R0531	Ramatroban ≥98% (HPLC), solid	116649-85-5	25MG	₹65112.38	2022-06-14	Buy

Product number	Packaging	Price	Buy
R0531	5MG	₹16908.65	Buy
R0531	25MG	₹65112.38	Buy

Ramatroban Chemical Properties,Uses,Production

Description

Ramatroban, originally developed for the treatment of cardiovascular pathologies as thromboembolism, was finally introduced in Japan for the treatment of allergic rhinitis. It is a (3R)-enantiomer that can be synthesized in 5 steps from 3-oxo-1,2,3,4- tetrahydrocarbazole by stereoselective reductive amination, using S-phenethylamine as the chiral source, followed by hydrogenolysis, sulfonylation and finally 2-step Ncarboxyethylation. Ramatroban is a potent antagonist of prostaglandin receptors (PGD₂, PGH₂) and thromboxane receptors (TxA₂); accordingly, it blocks the contractions induced by thromboxane or TxA₂-mimetics in animal and human airway smooth muscle. It also prevents, when administered i.v., p.o. or by aerosol, bronchoconstriction induced by PGD₂ or antigen. In animal models of nasal allergy, ramatroban inhibits antigen-induced neutrophil infiltration into nasal mucosa and also inhibits nasal symptoms. In several species including humans, it is well-absorbed, extensively protein-bound (>95%) and eliminated mainly as a glucuro-conjugate; in man, its terminal half-life is 2 to 3 hours.

Chemical Properties

WHite to Off-White Solid

Uses

A thromboxane receptor antagonist for use in the treatment of coronary artery disease.

Biological Activity

Potent dual antagonist of TP/DP 2 (CRTH2) prostanoid receptors (K i values are 4.3, 4.5 and > 10000 nM for hDP 2 , hTP and hDP 1 receptors respectively). Suppresses PGD 2 -induced migration of human eosinophils (IC 50 = 170 nM).

Ramatroban Preparation Products And Raw materials

Raw materials

Benzenesulfonamide, N-[(3R)-9-(2-cyanoethyl)-2,3,4,9-tetrahydro-1H-carbazol-3-yl]-4-fluoro- 5-OXO-TETRAHYDROCARBAZOLE ETHYLENE KETAL 1,2,4,9-TETRAHYDRO-CARBAZOL-3-ONE (R)-3-Amino-1,2,3,4-tetrahydrocarbazole 1,4-Dioxaspiro[4.5]decan-8-one

Phenylhydrazine

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Preparation Products

Ramatroban Suppliers

Global( 187)Suppliers

Supplier	Tel	Country	ProdList	Advantage	Inquiry
A.J Chemicals	91-9810153283	New Delhi, India	6124	58	Inquiry
CLEARSYNTH LABS LTD.	+91-22-45045900	Hyderabad, India	6351	58	Inquiry
Capot Chemical Co.,Ltd.	571-85586718 +8613336195806	China	29798	60	Inquiry
Hangzhou FandaChem Co.,Ltd.	008657128800458; +8615858145714	China	9337	55	Inquiry
career henan chemical co	+86-0371-86658258 +8613203830695	China	29898	58	Inquiry
BOC Sciences	+1-631-485-4226	United States	19553	58	Inquiry
Chongqing Chemdad Co., Ltd	+86-023-6139-8061 +86-86-13650506873	China	39916	58	Inquiry
CONIER CHEM AND PHARMA LIMITED	+8618523575427	China	49391	58	Inquiry
SIMAGCHEM CORP	+86-13806087780	China	17367	58	Inquiry
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	United States	19892	58	Inquiry

Supplier	Advantage
A.J Chemicals	58
CLEARSYNTH LABS LTD.	58
Capot Chemical Co.,Ltd.	60
Hangzhou FandaChem Co.,Ltd.	55
career henan chemical co	58
BOC Sciences	58
Chongqing Chemdad Co., Ltd	58
CONIER CHEM AND PHARMA LIMITED	58
SIMAGCHEM CORP	58
TargetMol Chemicals Inc.	58

Ramatroban Spectrum

Ramatroban(116649-85-5)¹HNMR

116649-85-5(Ramatroban)Related Search:

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BAY-U3405 3R-[[(4-FLUOROPHENYL)SULFONYL]AMINO]-1,2,3,4-TETRAHYDRO-9H-CARBAZOLE-9-PROPANOIC ACID (3R)-3-[[(4-Fluorophenyl)sulfonyl]amino]-1,2,3,4-tetrahydro-9H-carbazole-9-propionic acid 3-[(3R)-3-(4-Fluorophenylsulfonylamino)-1,2,3,4-tetrahydro-9H-carbazole-9-yl]propionic acid (R)-3-(3-(4-fluorophenylsulfonamido)-3,4-dihydro-1H-carbazol-9(2H)-yl)propanoic acid RAFFINOSE UNDECAACETATE, D-(+)-(RG) (3R)-3-[[(4-Fluorophenyl)sulfonyl]amino]-1,2,3,4-tetrahydro-9H-carbazole-9-propanoicacid RaMatroban(BAY-u3405) 9H-Carbazole-9-propanoic acid, 3-[[(4-fluorophenyl)sulfonyl]amino]-1,2,3,4-tetrahydro-, (3R)- (9CI) 9H-Carbazole-9-propanoic acid, 3-[[(4-fluorophenyl)sulfonyl]amino]-1,2,3,4-tetrahydro-, (R)- Baynas 3R-[[(4-Fluorophenyl)sulfonyl]amino]-1,2,3,4-tetrahydro-9H-carbazole-9- Ramatroban for research RaMantroban RAMATROBAN BAY U3405; BAY-U3405 CS-1350 3-(1,2,3,4-tetrahydrocarbazol-9-yl)propanoic acid [(4-fluorophenyl)sulfonylamino] ester 9H-Carbazole-9-propanoic acid, 3-[[(4-fluorophenyl)sulfonyl]amino]-1,2,3,4-tetrahydro-, (3R)- (R)-3-[3-[(4-Fluorophenyl)sulfonamido]-1,2,3,4-tetrahydro-9H-carbazol-9-yl]propanoic Acid Ray ma music class 116649-85-5 C21H21FN2O4S Inhibitors Intermediates & Fine Chemicals Pharmaceuticals