Bunitrolol
- CAS No.
- 34915-68-9
- Chemical Name:
- Bunitrolol
- Synonyms
- Bunitrolol;dl-Bunitolol;2-nitrilo-n-tert-butylphenoxypropanolamine;1-tert-Butylamino-3-(2-cyanophenoxy)-2-propanol;3-(tert-butylamino)-1-(m-cyanophenoxy)-2-propano;1-tert-Butylamino-3-(2-nitrilophenoxy)-2-propanol;o-(3-(tert-butylamino)-2-hydroxypropoxy)-benzonitril;o-[3-(tert-Butylamino)-2-hydroxypropoxy]benzonitrile;2-(3-(tert-ButylaMino)-2-hydroxypropoxy)benzonitrile;1-(2-Cyanophenoxy)-2-hydroxy-3-tert-butylaminopropane
- CBNumber:
- CB5947087
- Molecular Formula:
- C14H20N2O2
- Molecular Weight:
- 248.32
- MOL File:
- 34915-68-9.mol
- MSDS File:
- SDS
- Modify Date:
- 2023/5/4 17:34:38
| Melting point | 163-165 °C |
|---|---|
| Boiling point | 414.2±35.0 °C(Predicted) |
| Density | 1.09±0.1 g/cm3(Predicted) |
| storage temp. | Refrigerator, under inert atmosphere |
| solubility | Chloroform (Slightly), DMSO (Sparingly), Methanol (Slightly, Sonicated) |
| form | Solid |
| pka | 13.76±0.20(Predicted) |
| color | Colourless to Pale Yellow Sticky Oil |
Bunitrolol Chemical Properties,Uses,Production
Originator
St resson,Boehringer Ingelheim,Boehringer Ingelheim,1976
Manufacturing Process
Epichlorohydrin and 2-cyanophenol are first reacted to give 1-(2-
cyanophenoxy)-2,3-epoxypropane.
15 g (0.085 mol) of 1-(2-cyanophenoxy)-2,3-epoxy propane were dissolved in
100 ml of ethanol and 18.6 g (0.255 mol) of t-butylamine were added
thereto. After standing for 1 hour at room temperature, the solution was
heated at 60°-70°C for 2 hours after which the volatile constituents were
distilled off in vacuo. The residue was digested with dilute HCl, and the
insoluble constituents were vacuum filtered off. Then the filtrate was made
alkaline with NaOH and the precipitating base was taken up in ether. After the
ether solution had been dried over MgSO4, the ether was distilled off and the
residue was dissolved in ethanol and by addition of ethereal HCl, the
hydrochloride was precipitated there from in crystalline form which after
recrystallization from ethanol with an addition of ether gave9.8 g of 1-(2-
cyanophenoxy)-2-hydroxy-3-t-butylamino propane hydrochloride having a
melting point of 163°-165°C.
Therapeutic Function
Antianginal
Bunitrolol Preparation Products And Raw materials
Bunitrolol Suppliers
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| Alfa Chemistry | United States | 24072 | 58 | Inquiry | |
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| Hubei Shishun Biotechnology Co. Ltd | 027-59223025 15107168801 | China | 9797 | 58 | Inquiry |
| Hubei Wande Chemical Co., Ltd | 027-59210159 15377098680 | China | 9892 | 58 | Inquiry |
| Shaanxi Xihua Chemical Industry Co., Ltd | 029-89586681 15829046862 | China | 9416 | 58 | Inquiry |
| LGC Science (Shanghai) Ltd. | 17717235263 | China | 17730 | 58 | Inquiry |
| Shanghai Haohong Scientific Co., Ltd. | 400-8210725 4008210725 | China | 40109 | 58 | Inquiry |
| AK Scientific, Inc. | 650 494 8666 | United States | 6347 | 65 | Inquiry |
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