2-Amino-N-(2-chloro-6-methylphenyl)thiazole-5-carboxamide
- CAS No.
- 302964-24-5
- Chemical Name:
- 2-Amino-N-(2-chloro-6-methylphenyl)thiazole-5-carboxamide
- Synonyms
- EOS-61515;2-Amino-N-(2-chL;Dasatinib Int N-2;The dimer impurity;Dasatinib IMpurity 2;Dasatinib Impurity L;Dasatinib Impurity 27;dasatinib interMediate;Dasatinib EP Impurity-A;2-AMino-N-(2-chloro-6-Meth
- CBNumber:
- CB61090897
- Molecular Formula:
- C11H10ClN3OS
- Molecular Weight:
- 267.73
- MOL File:
- 302964-24-5.mol
- Modify Date:
- 2024/4/2 14:59:00
| Melting point | 208.0 to 212.0 °C |
|---|---|
| Boiling point | 362.0±37.0 °C(Predicted) |
| Density | 1.474±0.06 g/cm3(Predicted) |
| storage temp. | under inert gas (nitrogen or Argon) at 2–8 °C |
| solubility | DMSO (Slightly), Methanol (Sparingly) |
| form | powder to crystal |
| pka | 11.09±0.70(Predicted) |
| color | White to Light yellow |
| InChI | InChI=1S/C11H10ClN3OS/c1-6-3-2-4-7(12)9(6)15-10(16)8-5-14-11(13)17-8/h2-5H,1H3,(H2,13,14)(H,15,16) |
| InChIKey | VVOXTERFTAJMAA-UHFFFAOYSA-N |
| SMILES | S1C(C(NC2=C(C)C=CC=C2Cl)=O)=CN=C1N |
| CAS DataBase Reference | 302964-24-5(CAS DataBase Reference) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
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|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302 | |||||||||
| Precautionary statements | P264-P270-P301+P312-P330-P501 | |||||||||
| HS Code | 29333990 | |||||||||
| NFPA 704 |
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2-Amino-N-(2-chloro-6-methylphenyl)thiazole-5-carboxamide price More Price(2)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TCI Chemicals (India) | A2773 | 2-Amino-N-(2-chloro-6-methylphenyl)thiazole-5-carboxamide min. 98.0 % | 302964-24-5 | 1G | ₹3300 | 2022-05-26 | Buy |
| TCI Chemicals (India) | A2773 | 2-Amino-N-(2-chloro-6-methylphenyl)thiazole-5-carboxamide min. 98.0 % | 302964-24-5 | 5G | ₹8800 | 2022-05-26 | Buy |
2-Amino-N-(2-chloro-6-methylphenyl)thiazole-5-carboxamide Chemical Properties,Uses,Production
Synthesis
2-Amino-N-(2-chloro-6-methylphenyl)thiazole-5-carboxamide is synthesised using Tert-butyl (5-((2-chloro-6-methylphenyl)carbamoyl)thiazol-2-YL)carbamate as a raw material by chemical reaction. The specific synthesis steps are as follows:
To the stirred solution of trifluoroacetic acid (TFA) (250.0 mL) added tert-butyl (5-((2-chloro-6-methylphenyl)carbamoyl)thiazol-2-yl)carbamate 23 (25.0 g, 0.07 mol) and stirred for 2h at 25-30°C. Reaction completion was confirmed by TLC, distilled the TFA and the residue was diluted with ethyl acetate (EtOAc),(250.0 mL). Ethyl acetate layer was washed with saturated NaHCO3 solution (2 X 25.0 mL), water, followed bysaturated NaCl solution (125.0 mL). Ethyl acetate layer was dried over Na2SO4 and concentrated. The residual mass on treatment with methyl tert-butyl ether (250.0) gave 9 (16.2 g, 89percent) [11].IR (KBr, cm-1): 3382.4, 3284.85 (N-H), 1627.02 (C=O), 1644; 1H NMR spectrum (400 MHz, DMSO-d6), δ, ppm(J, Hz): 9.63 (s, 1H, thiazole-H), 7.86 (s, 1H), 7.60 (s, 2H, -NH2), 7.38 (dd, 1H, J =7.5, 4.02, Ar-H), 7.20-7.22 (m,2H, J =7.5, Ar-H), 2.20 (s, 3H, Ar-CH3); 13C NMR spectrum (100 MHz, DMSO-d6), δ, ppm: 172.2, 159.6, 143.2,138.9, 133.7, 132.5, 129.0, 128.0, 127.0, 120.7 and 18.3; MS (ESI) m/z 268.0 [M + H] + [11].
2-Amino-N-(2-chloro-6-methylphenyl)thiazole-5-carboxamide Preparation Products And Raw materials
Raw materials
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| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| A.R. LIFE SCIENCES PVT. LTD. | +91-914040267679 +91-8519993257 | Hyderabad, India | 100 | 58 | Inquiry |
| Molkem Chemicals | +91-917228022464 +91-7228022464 | Ahmedabad, India | 138 | 58 | Inquiry |
| KROMOZOME | +91-91-9650900955 +91-09650900955 | Maharashtra, India | 71 | 58 | Inquiry |
| Credas Labs Pvt Ltd | +91 9133918031 | Hyderabad, India | 119 | 58 | Inquiry |
| VGS SYNTHESIS PRIVATE LIMITED | +91-9866975588 +91-9866975588 | Hyderabad, India | 1818 | 58 | Inquiry |
| GLP Pharma Standards | +91 9866074638 | Hyderabad, India | 1644 | 58 | Inquiry |
| Besil Chem LLP | +91-7760252666 +91-9880731835 | Bangalore, India | 163 | 58 | Inquiry |
| Vijaya Pharma And Life Science | +91-8939866271 +91-8939866271 | Tamil Nadu, India | 320 | 58 | Inquiry |
| Myosynth Laboratories Pvt Ltd | +91-8913266227 +91-9885891884 | AndhraPradesh, India | 49 | 58 | Inquiry |
| Lanya Chem Industries Pvt Ltd | +91-7290016802 +91-9996207397 | Haryana, India | 34 | 58 | Inquiry |
| Supplier | Advantage |
|---|---|
| A.R. LIFE SCIENCES PVT. LTD. | 58 |
| Molkem Chemicals | 58 |
| KROMOZOME | 58 |
| Credas Labs Pvt Ltd | 58 |
| VGS SYNTHESIS PRIVATE LIMITED | 58 |
| GLP Pharma Standards | 58 |
| Besil Chem LLP | 58 |
| Vijaya Pharma And Life Science | 58 |
| Myosynth Laboratories Pvt Ltd | 58 |
| Lanya Chem Industries Pvt Ltd | 58 |
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