Prazosin hydrochloride
- CAS No.
- 19237-84-4
- Chemical Name:
- Prazosin hydrochloride
- Synonyms
- PRAZOSIN HCL;hypovase;pratsiol;sinetens;Vasoflex;peripress;Adversuten;Alpress LP;cp-12299-1;deprazolin
- CBNumber:
- CB6120870
- Molecular Formula:
- C19H22ClN5O4
- Molecular Weight:
- 419.86
- MOL File:
- 19237-84-4.mol
- MSDS File:
- SDS
- Modify Date:
- 2023/6/30 15:45:59
| Melting point | 277 - 280 °C |
|---|---|
| storage temp. | 2-8°C |
| solubility | H2O: 1 mg/mL, clear, colorless |
| form | solid |
| color | white |
| Water Solubility | Soluble in dimethyl sulfoxide, ethanol, water, methanol. |
| Merck | 14,7717 |
| BRN | 4303561 |
| InChIKey | WFXFYZULCQKPIP-UHFFFAOYSA-N |
| CAS DataBase Reference | 19237-84-4(CAS DataBase Reference) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS07,GHS08 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302-H315-H319-H335-H361 | |||||||||
| Precautionary statements | P201-P301+P312+P330-P302+P352-P305+P351+P338-P308+P313 | |||||||||
| Hazard Codes | Xn | |||||||||
| Risk Statements | 22-36/37/38-62 | |||||||||
| Safety Statements | 28-36 | |||||||||
| RIDADR | 3249 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | VA1350000 | |||||||||
| F | 10 | |||||||||
| HazardClass | 6.1(b) | |||||||||
| PackingGroup | III | |||||||||
| HS Code | 2934990002 | |||||||||
| Toxicity | dog,LD50,oral,> 700mg/kg (700mg/kg),GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDSKIDNEY, URETER, AND BLADDER: OTHER CHANGES GASTROINTESTINAL: NAUSEA OR VOMITING,Oyo Yakuri. Pharmacometrics. Vol. 17, Pg. 39, 1979. | |||||||||
| NFPA 704 |
|
Prazosin hydrochloride price More Price(6)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | P7791 | Prazosin hydrochloride ≥99.0% (HPLC) | 19237-84-4 | 50MG | ₹6321.8 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | PHR3099 | Prazosin Hydrochloride pharmaceutical secondary standard, certified reference material | 19237-84-4 | 500MG | ₹20372.65 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | P7791 | Prazosin hydrochloride ≥99.0% (HPLC) | 19237-84-4 | 250MG | ₹24486.15 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | P7791 | Prazosin hydrochloride ≥99.0% (HPLC) | 19237-84-4 | 1G | ₹78968.38 | 2022-06-14 | Buy |
| TCI Chemicals (India) | P0938 | Prazosin Hydrochloride | 19237-84-4 | 100MG | ₹5300 | 2022-05-26 | Buy |
Prazosin hydrochloride Chemical Properties,Uses,Production
Chemical Properties
Off-White to Yellow Powder
Uses
Prazosin Hydrochloride (Terazosin EP Impurity K) is an antihypertensive. α1-Adrenergic blocker.
General Description
The antihypertensive effectsof prazosin hydrochloride, 1-(4-amino-6,7-dimethoxy-2-quinazolinyl)-4-(2-furoyl)piperazine monohydrochloride(Minipress), are caused by peripheral vasodilation as a resultof its blockade of 1-adrenergic receptors. In ligand-bindingstudies, prazosin hydrochloride has 5,000-fold greater affinityfor α1-receptors than for some α2-adrenergic receptors.
Biological Activity
α 1 and α 2B -adrenoceptor antagonist. Also a potent antagonist at the melatonin MT 3 receptor (K i = 10.2 nM). Also available as part of the α 1 -Adrenoceptor Tocriset™ and Mixed Adrenergic Tocriset™ .
Clinical Use
Prazosin hydrochloride is readily absorbed, and plasmaconcentrations reach a peak about 3 hours after administration.Plasma half-life is between 2 and 3 hours. Prazosin hydrochlorideis highly bound to plasma protein; it does notcause adverse reactions, however, with drugs that might bedisplaced from their protein-binding sites (e.g., cardiac glycosides).It may cause severe orthostatic hypertension becauseof its -adrenergic blocking action, which preventsthe reflex venous constriction that is activated when an individualsits up from a prone position.
Purification Methods
The salt is recrystallised by dissolving it in hot MeOH, adding a small volume of MeOH/HCl (dry MeOH saturated with dry HCl gas) followed by dry Et2O until crystallisation is complete. Dry it in vacuo over solid KOH till the odour of HCl is absent. It has been recrystallised from hot H2O, the crystals are washed with H2O, and the H2O is removed azeotropically with CH2Cl2, and dried in a vacuum. [NMR and IR: Honkanen et al. J Heterocycl Chem 17 797 1980, cf Armarego & Reece Aust J Chem 34 1561 1981.] It is an antihypertensive drug and is an 1-adrenergic antagonist [Brosman et al. Proc Natl Acad Sci USA 82 5915 1985].
Prazosin hydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| ALMELO PRIVATE LIMITED | +91-9100991345 +91-8500807769 | Telangana, India | 114 | 58 | Inquiry |
| Synthokem Labs Private Limited | +91-9966400646 +91-9966400646 | Hyderabad, India | 15 | 58 | Inquiry |
| Nuray Chemicals Pvt Ltd | +91-4066616700 +91-8220444745 | Tamil Nadu, India | 49 | 58 | Inquiry |
| Aruvi Labs | +91-8056181939 +91-8056181939 | Tamil Nadu, India | 149 | 58 | Inquiry |
| Bal Pharma Limited | +91-8041379581 +91-8041379500 | Karnataka, India | 20 | 58 | Inquiry |
| Rivashaa Agrotech Biopharma Pvt. Ltd. | +91-26463395 +91-7926462688 | Gujarat, India | 1615 | 58 | Inquiry |
| Granules India Limited | +91-4069043500 +91-4069043500 | Telangana, India | 30 | 58 | Inquiry |
| OCEAN TRADING CORPORATION | +91(22) 24921669 | New Delhi, India | 6211 | 58 | Inquiry |
| GRANULES INDIA LTD | +91 40 30660000 | New Delhi, India | 33 | 58 | Inquiry |
| MSN ORGANICS PRIVATE LTD | 91-40-3043-8600 | New Delhi, India | 22 | 58 | Inquiry |
| Supplier | Advantage |
|---|---|
| ALMELO PRIVATE LIMITED | 58 |
| Synthokem Labs Private Limited | 58 |
| Nuray Chemicals Pvt Ltd | 58 |
| Aruvi Labs | 58 |
| Bal Pharma Limited | 58 |
| Rivashaa Agrotech Biopharma Pvt. Ltd. | 58 |
| Granules India Limited | 58 |
| OCEAN TRADING CORPORATION | 58 |
| GRANULES INDIA LTD | 58 |
| MSN ORGANICS PRIVATE LTD | 58 |
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