Trimethylamine N-oxide
- CAS No.
- 1184-78-7
- Chemical Name:
- Trimethylamine N-oxide
- Synonyms
- TMAO;Trimethylamine oxide;N,N-dimethylmethanamine oxide;trimethyloxamine;Trimetlylamine Oxide;Triox;TMANO Anhydrous;TRIMETHYLAMINOXIDE;rimethylamineN-oxide;TRIMETHYLAMINE N-OXIDE
- CBNumber:
- CB6140124
- Molecular Formula:
- C3H9NO
- Molecular Weight:
- 75.11
- MOL File:
- 1184-78-7.mol
- MSDS File:
- SDS
- Modify Date:
- 2023/12/26 17:34:35
| Melting point | 220-222 °C (lit.) |
|---|---|
| Boiling point | 133.8°C (rough estimate) |
| Density | 0.9301 (rough estimate) |
| vapor pressure | 23.5Pa at 20℃ |
| refractive index | 1.4698 (estimate) |
| FEMA | 4245 | TRIMETHYLAMINE OXIDE |
| storage temp. | Hygroscopic, Room Temperature, under inert atmosphere |
| solubility | Chloroform, DMSO, Methanol (Slightly) |
| pka | 4.65(at 25℃) |
| form | Solid |
| color | Pale Yellow |
| Odor | odorless |
| Water Solubility | 793g/L at 24.5℃ |
| Merck | 14,9711 |
| JECFA Number | 1614 |
| Stability | Hygroscopic |
| LogP | -2.79 |
| EPA Substance Registry System | Methanamine, N,N-dimethyl-, N-oxide (1184-78-7) |
Trimethylamine N-oxide price More Price(4)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | 317594 | Trimethylamine N-oxide 95% | 1184-78-7 | 1G | ₹5813.03 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 317594 | Trimethylamine N-oxide 95% | 1184-78-7 | 5G | ₹16421.53 | 2022-06-14 | Buy |
| TCI Chemicals (India) | T1362 | Trimethylamine N-Oxide Anhydrous | 1184-78-7 | 1G | ₹3300 | 2022-05-26 | Buy |
| TCI Chemicals (India) | T1362 | Trimethylamine N-Oxide Anhydrous | 1184-78-7 | 5G | ₹10800 | 2022-05-26 | Buy |
Trimethylamine N-oxide Chemical Properties,Uses,Production
Description
Trimethylamine N-oxide (TMAO) is a metabolite of choline, phosphatidylcholine, and L-carnitine . It is formed by gut microbiota-mediated metabolism of choline, phosphatidylcholine, and L-carnitine to TMA followed by oxidation of TMA by flavin-containing monooxygenase 3 (FMO3) in the liver. Dietary administration of TMAO (0.12% w/w) increases renal tubulointerstitial fibrosis, collagen deposition, and Smad3 phosphorylation in mice and increases aortic lesion area in atherosclerosis-prone ApoE-/- mice. Plasma levels of TMAO are elevated in patients with chronic kidney disease and decreased in patients with active, compared with inactive, ulcerative colitis. Elevated plasma levels of TMAO are associated with increased risk of cardiovascular disease.
Chemical Properties
White crystalline powder
Uses
Trimethylamine?N-oxide can be used:
- As a demetallation?and decarbonylation?reagent for organometallic compounds.
- To prepare azomethine ylide by reaction with lithium di-isopropylamide. This, in turn, may be reacted with simple alkenes to obtain corresponding pyrrolidines.
- To mediate the conversion of thiols to disulfides.
Definition
ChEBI: An N-oxide derived from triethylamine.
General Description
Trimethylamine?N-oxide is an organic compound that belongs to the class of amine oxides. It is generally found in the tissues of marine organisms, wherein it helps protect them from harsh conditions like salinity, hydrostatic pressure, temperature, and high urea.
Trimethylamine N-oxide Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| GRK RESEARCH LABORATORIES PVT LTD | +91-8249607014 +91-9849401944 | Hyderabad, India | 205 | 58 | Inquiry |
| TCI Chemicals (India) Pvt. Ltd. | 1800 425 7889 | New Delhi, India | 6778 | 58 | Inquiry |
| Capot Chemical Co.,Ltd. | 571-85586718 +8613336195806 | China | 29798 | 60 | Inquiry |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | China | 21673 | 55 | Inquiry |
| career henan chemical co | +86-0371-86658258 +8613203830695 | China | 29897 | 58 | Inquiry |
| Chongqing Chemdad Co., Ltd | +86-023-6139-8061 +86-86-13650506873 | China | 39916 | 58 | Inquiry |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | China | 49391 | 58 | Inquiry |
| SIMAGCHEM CORP | +86-13806087780 | China | 17367 | 58 | Inquiry |
| Career Henan Chemica Co | +86-0371-86658258 +8613203830695 | China | 30253 | 58 | Inquiry |
| Hefei TNJ Chemical Industry Co.,Ltd. | 0551-65418671 | China | 34571 | 58 | Inquiry |
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