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CLOZAPINE N-OXIDE

CLOZAPINE N-OXIDE Structure
CAS No.
34233-69-7
Chemical Name:
CLOZAPINE N-OXIDE
Synonyms
CLOZAPINE N-OXIDE;Clozapine Impurity 16;Clozapine N-Oxide imp;Clozapine N-oxide (CNO);Clozapine N-oxide solution;Clozapine N-oxide Methanol Adduct;Clozapine N-oxide dihydrochloride NEW;Clozapine N-oxide (4-oxido-piprazinyl);Clozapine N-Oxide (1.0 mg/mL in Methanol);MAJORMETABOLITEOFCLOZAPINE.POSSESSESLITTLEORNOACTIVITYAT5-HTRECEPTORS
CBNumber:
CB4759216
Molecular Formula:
C18H19ClN4O
Molecular Weight:
342.82
MOL File:
34233-69-7.mol
MSDS File:
SDS
Modify Date:
2023/10/7 17:44:49
Request For Quotation

CLOZAPINE N-OXIDE Properties

Melting point 190-248°C
Flash point 9℃
storage temp. -20°C Freezer, Under Inert Atmosphere
solubility Soluble in DMSO.
form powder
pka 6.86±0.20(Predicted)
color Yellow
Stability Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
InChIKey OGUCZBIQSYYWEF-UHFFFAOYSA-N

SAFETY

Risk and Safety Statements

Symbol(GHS) 
GHS06
Signal word  Danger
Hazard statements  H301-H336
Precautionary statements  P301+P310+P330
Hazard Codes  Xn,T,F
Risk Statements  22-36/37/38-39/23/24/25-23/24/25-11
Safety Statements  26-36-45-36/37-16-7
RIDADR  UN 2811 6.1/PG 3
WGK Germany  3
RTECS  HP1760000
HazardClass  6.1(b)
PackingGroup  III
HS Code  29335990
NFPA 704
0
4 0

CLOZAPINE N-OXIDE price More Price(2)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich(India) SML2304 Clozapine N-oxide hydrochloride ≥98% (HPLC), Water soluble Clozapine N-oxide 34233-69-7 5MG ₹21134.4 2022-06-14 Buy
Sigma-Aldrich(India) C0832 Clozapine N-oxide 34233-69-7 5MG ₹21173.7 2022-06-14 Buy
Product number Packaging Price Buy
SML2304 5MG ₹21134.4 Buy
C0832 5MG ₹21173.7 Buy

CLOZAPINE N-OXIDE Chemical Properties,Uses,Production

Chemical Properties

Yellow Solid

Uses

Clozapine N-oxide has been used:

  • for the activation of human M4 muscarinic (hM4Di) in primary motor cortex
  • for inducing in vivo chemogenetic manipulation and impairing locomotor activity in Th-cre transgenic mice
  • in behavioral testing in mice and for stimulating (HEK293) cells

General Description

Clozapine N-oxide (CNO), inactive from of clozapine drug, activates G-protein-coupled receptors (GPCRs). CNO serves as a synthetic ligand for engineered human muscarinic receptor. It elicits clozapine-like effects upon metabolic conversion. Clozapine conversion to CNO favors its passage through blood-brain barrier.

CLOZAPINE N-OXIDE Preparation Products And Raw materials

Raw materials

Preparation Products

CLOZAPINE N-OXIDE Suppliers

Global( 149)Suppliers
Supplier Tel Country ProdList Advantage Inquiry
AnalyticsStanza Inc +91-7032031309 +91-7032031309 Hyderabad, India 227 58 Inquiry
GLP Pharma Standards +91 9866074638 Hyderabad, India 1644 58 Inquiry
CLEARSYNTH LABS LTD. +91-22-45045900 Hyderabad, India 6351 58 Inquiry
Pharmaffiliates Analytics and Synthetics P. Ltd +91-172-5066494 Haryana, India 6773 58 Inquiry
SynZeal Research Pvt Ltd +1 226-802-2078 Gujarat, India 6522 58 Inquiry
Pharma Affiliates 172-5066494 Haryana, India 6761 58 Inquiry
Anant Pharmaceuticals Pvt. ltd +91 8550986868 Maharashtra, India 736 58 Inquiry
JSK Chemical 98797 67970 Gujarat, India 291 58 Inquiry
Olympus Chemicals & Fertilizers 08068441058Ext 121 Maharashtra, India 486 58 Inquiry
Hebei Mojin Biotechnology Co., Ltd +86 13288715578 +8613288715578 China 12460 58 Inquiry
Supplier Advantage
AnalyticsStanza Inc 58
GLP Pharma Standards 58
CLEARSYNTH LABS LTD. 58
Pharmaffiliates Analytics and Synthetics P. Ltd 58
SynZeal Research Pvt Ltd 58
Pharma Affiliates 58
Anant Pharmaceuticals Pvt. ltd 58
JSK Chemical 58
Olympus Chemicals & Fertilizers 58
Hebei Mojin Biotechnology Co., Ltd 58

CLOZAPINE N-OXIDE Spectrum

CLOZAPINE N-OXIDE(34233-69-7)1HNMR

34233-69-7(CLOZAPINE N-OXIDE)Related Search:

2-CHLOROMETHYL-3-METHYL-4-(2,2,2-TRIFLUOROETHOXY)PYRIDINE pidotiMod iMpurity E Acarbose 4-Chloro-2-propylsulfanyl-pyrimidine (2R,3R)-2-[(1R)-1-[3,5-Bis(trifluoroMethyl)phenyl]ethoxy]-3-(4-fluorophenyl)Morpholine
2-[2-(2-Methyl-5-nitroiMidazol-1-yl)ethoxy]ethanol 5-Nitro-1H-iMidazole-1-ethanol (2R,3S/2S,3R)-3-(4-Chloro-5-fluoro-6-pyrimidinyl)-2-(2,4-difluorophenyl)butan-2-ol hydrochloride Pyridine-N-oxide Pyridine-4-carboxylic acid N-oxide
Clozapine EP IMpurity D Trimethylamine N-oxide CLOZAPINE N-OXIDE Clozapine 2-AMINO-4-CHLORODIPHENYLAMINE
2-[(4-METHYLPIPERAZIN-1-YL)METHYL]ANILINE 4-CHLORODIPHENYLAMINE N-DESMETHYLCLOZAPINE
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e)(1,4)diazepine,8-chloro-11-(4-methyl-1-piperazinyl)-5h-dibenzo(n-oxide CLOZAPINE N-OXIDE 8-CHLORO-11-[4-METHYL-1-PIPERAZINYL]-5H-DIBENZO[B,E][1,4]DIAZEPINE N-OXIDE MAJORMETABOLITEOFCLOZAPINE.POSSESSESLITTLEORNOACTIVITYAT5-HTRECEPTORS Clozapine N-oxide Methanol Adduct Clozapine N-oxide solution Clozapine N-oxide (CNO) 8-Chloro-11-(4-methyl-4-oxido-1-piperazinyl)-5H-dibenzo[b,e][1,4]diazepine Clozapine impurity 5/Clozapine N-Oxide/4-(8-chloro-5H-dibenzo[b,e][1,4]diazepin-11-yl)-1-methylpiperazine 1-oxide Clozapine N-oxide dihydrochloride NEW Clozapine N-Oxide (1.0 mg/mL in Methanol) Clozapine N-oxide (4-oxido-piprazinyl) 5H-Dibenzo[b,e][1,4]diazepine, 8-chloro-11-(4-methyl-4-oxido-1-piperazinyl)- Clozapine N-OxideQ: What is Clozapine N-Oxide Q: What is the CAS Number of Clozapine N-Oxide Q: What is the storage condition of Clozapine N-Oxide Q: What are the applications of Clozapine N-Oxide Clozapine Impurity 16 3-Chloro-6-(4-methyl-4-oxidopiperazin-4-ium-1-yl)-5H-benzo[b][1,4]benzodiazepine Clozapine N-Oxide imp 4-(8-Chloro-5H-dibenzo[b,e][1,4]diazepin-11-yl)-1-methylpiperazine 1-oxide 34233-69-7 C18H19ClN4O C18H19ClN4O2HCl Various Metabolites and Impurities Metabolites