CLOZAPINE N-OXIDE
- CAS No.
- 34233-69-7
- Chemical Name:
- CLOZAPINE N-OXIDE
- Synonyms
- CLOZAPINE N-OXIDE;Clozapine Impurity 16;Clozapine N-Oxide imp;Clozapine N-oxide (CNO);Clozapine N-oxide solution;CLOZAPINE N-OXIDE, 10 mM in DMSO;Clozapine N-oxide Methanol Adduct;Clozapine N-oxide dihydrochloride NEW;Clozapine N-oxide (4-oxido-piprazinyl);Clozapine N-Oxide (1.0 mg/mL in Methanol)
- CBNumber:
- CB4759216
- Molecular Formula:
- C18H19ClN4O
- Molecular Weight:
- 342.82
- MOL File:
- 34233-69-7.mol
- MSDS File:
- SDS
- Modify Date:
- 2025/1/27 9:38:02
| Melting point | 190-248°C |
|---|---|
| Flash point | 9℃ |
| storage temp. | -20°C Freezer, Under Inert Atmosphere |
| solubility | Soluble in DMSO. |
| form | powder |
| pka | 6.86±0.20(Predicted) |
| color | Yellow |
| biological source | synthetic |
| Stability | Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months. |
| InChIKey | OGUCZBIQSYYWEF-UHFFFAOYSA-N |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS06 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H301-H336 | |||||||||
| Precautionary statements | P301+P310+P330 | |||||||||
| Hazard Codes | Xn,T,F | |||||||||
| Risk Statements | 22-36/37/38-39/23/24/25-23/24/25-11 | |||||||||
| Safety Statements | 26-36-45-36/37-16-7 | |||||||||
| RIDADR | UN 2811 6.1/PG 3 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | HP1760000 | |||||||||
| HazardClass | 6.1(b) | |||||||||
| PackingGroup | III | |||||||||
| HS Code | 29335990 | |||||||||
| NFPA 704 |
|
CLOZAPINE N-OXIDE price More Price(2)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | SML2304 | Clozapine N-oxide hydrochloride ≥98% (HPLC), Water soluble Clozapine N-oxide | 34233-69-7 | 5MG | ₹21134.4 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | C0832 | Clozapine N-oxide | 34233-69-7 | 5MG | ₹21173.7 | 2022-06-14 | Buy |
CLOZAPINE N-OXIDE Chemical Properties,Uses,Production
Chemical Properties
Yellow Solid
Uses
Clozapine N-oxide has been used:
- for the activation of human M4 muscarinic (hM4Di) in primary motor cortex
- for inducing in vivo chemogenetic manipulation and impairing locomotor activity in Th-cre transgenic mice
- in behavioral testing in mice and for stimulating (HEK293) cells
General Description
Clozapine N-oxide (CNO), inactive from of clozapine drug, activates G-protein-coupled receptors (GPCRs). CNO serves as a synthetic ligand for engineered human muscarinic receptor. It elicits clozapine-like effects upon metabolic conversion. Clozapine conversion to CNO favors its passage through blood-brain barrier.
CLOZAPINE N-OXIDE Preparation Products And Raw materials
Raw materials
Preparation Products
Global( 175)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| AnalyticsStanza Inc | +91-7032031309 +91-7032031309 | Hyderabad, India | 226 | 58 | Inquiry |
| CLEARSYNTH LABS LTD. | +91-22-45045900 | Hyderabad, India | 6257 | 58 | Inquiry |
| Pharma Affiliates | 172-5066494 | Haryana, India | 6754 | 58 | Inquiry |
| Anant Pharmaceuticals Pvt. ltd | +91 8550986868 | Maharashtra, India | 736 | 58 | Inquiry |
| JSK Chemical | 98797 67970 | Gujarat, India | 291 | 58 | Inquiry |
| Olympus Chemicals & Fertilizers | 08068441058Ext 121 | Maharashtra, India | 486 | 58 | Inquiry |
| Pharmaffiliates Analytics and Synthetics P. Ltd | +91-172-5066494 | Haryana, India | 6739 | 58 | Inquiry |
| SynZeal Research Pvt Ltd | +1 226-802-2078 | Gujarat, India | 6514 | 58 | Inquiry |
| Hebei Mujin Biotechnology Co.,Ltd | +86 13288715578 +8613288715578 | China | 12809 | 58 | Inquiry |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | China | 33024 | 60 | Inquiry |
34233-69-7(CLOZAPINE N-OXIDE)Related Search:
2-CHLOROMETHYL-3-METHYL-4-(2,2,2-TRIFLUOROETHOXY)PYRIDINE
pidotiMod iMpurity E
Acarbose
4-Chloro-2-propylsulfanyl-pyrimidine
(2R,3R)-2-[(1R)-1-[3,5-Bis(trifluoroMethyl)phenyl]ethoxy]-3-(4-fluorophenyl)Morpholine
2-[2-(2-Methyl-5-nitroiMidazol-1-yl)ethoxy]ethanol
5-Nitro-1H-iMidazole-1-ethanol
(2R,3S/2S,3R)-3-(4-Chloro-5-fluoro-6-pyrimidinyl)-2-(2,4-difluorophenyl)butan-2-ol hydrochloride
Pyridine-N-oxide
Pyridine-4-carboxylic acid N-oxide
chevron_left
1of4
chevron_right
e)(1,4)diazepine,8-chloro-11-(4-methyl-1-piperazinyl)-5h-dibenzo(n-oxide
CLOZAPINE N-OXIDE
8-CHLORO-11-[4-METHYL-1-PIPERAZINYL]-5H-DIBENZO[B,E][1,4]DIAZEPINE N-OXIDE
MAJORMETABOLITEOFCLOZAPINE.POSSESSESLITTLEORNOACTIVITYAT5-HTRECEPTORS
Clozapine N-oxide Methanol Adduct
Clozapine N-oxide solution
Clozapine N-oxide (CNO)
8-Chloro-11-(4-methyl-4-oxido-1-piperazinyl)-5H-dibenzo[b,e][1,4]diazepine
Clozapine impurity 5/Clozapine N-Oxide/4-(8-chloro-5H-dibenzo[b,e][1,4]diazepin-11-yl)-1-methylpiperazine 1-oxide
Clozapine N-oxide dihydrochloride NEW
Clozapine N-Oxide (1.0 mg/mL in Methanol)
Clozapine N-oxide (4-oxido-piprazinyl)
5H-Dibenzo[b,e][1,4]diazepine, 8-chloro-11-(4-methyl-4-oxido-1-piperazinyl)-
Clozapine N-OxideQ: What is
Clozapine N-Oxide Q: What is the CAS Number of
Clozapine N-Oxide Q: What is the storage condition of
Clozapine N-Oxide Q: What are the applications of
Clozapine N-Oxide
Clozapine Impurity 16
3-Chloro-6-(4-methyl-4-oxidopiperazin-4-ium-1-yl)-5H-benzo[b][1,4]benzodiazepine
Clozapine N-Oxide imp
4-(8-Chloro-5H-dibenzo[b,e][1,4]diazepin-11-yl)-1-methylpiperazine 1-oxide
Clozapine N-oxide (4-oxido-piprazinyl) in methanol
Clozapine N-oxide, Metabolite of Clozapine (aqueous solution)
Clozapine N-oxide, Metabolite of Clozapine
CLOZAPINE N-OXIDE, 10 mM in DMSO
34233-69-7
C18H19ClN4O
C18H19ClN4O2HCl
Various Metabolites and Impurities
Metabolites