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CLOZAPINE N-OXIDE

CLOZAPINE N-OXIDE Structure
  • ₹21134.4 - ₹21173.7
  • Product name: CLOZAPINE N-OXIDE
  • CAS: 34233-69-7
  • MF: C18H19ClN4O
  • MW: 342.82
  • EINECS:
  • MDL Number:MFCD00210190
  • Synonyms:e)(1,4)diazepine,8-chloro-11-(4-methyl-1-piperazinyl)-5h-dibenzo(n-oxide ;CLOZAPINE N-OXIDE;8-CHLORO-11-[4-METHYL-1-PIPERAZINYL]-5H-DIBENZO[B,E][1,4]DIAZEPINE N-OXIDE;MAJORMETABOLITEOFCLOZAPINE.POSSESSESLITTLEORNOACTIVITYAT5-HTRECEPTORS;Clozapine N-oxide Methanol Adduct;Clozapine N-oxide solution;Clozapine N-oxide (CNO);8-Chloro-11-(4-methyl-4-oxido-1-piperazinyl)-5H-dibenzo[b,e][1,4]diazepine
2 prices
Selected condition:

Brand

  • Sigma-Aldrich(India)

Package

  • 5MG
  • ManufacturerSigma-Aldrich(India)
  • Product numberSML2304
  • Product descriptionClozapine N-oxide hydrochloride ≥98% (HPLC), Water soluble Clozapine N-oxide
  • Packaging5MG
  • Price₹21134.4
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberC0832
  • Product descriptionClozapine N-oxide
  • Packaging5MG
  • Price₹21173.7
  • Updated2022-06-14
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
Sigma-Aldrich(India) SML2304 Clozapine N-oxide hydrochloride ≥98% (HPLC), Water soluble Clozapine N-oxide 5MG ₹21134.4 2022-06-14 Buy
Sigma-Aldrich(India) C0832 Clozapine N-oxide 5MG ₹21173.7 2022-06-14 Buy

Properties

Melting point :190-248°C
Flash point :9℃
storage temp. :-20°C Freezer, Under Inert Atmosphere
solubility :Soluble in DMSO.
form :powder
pka :6.86±0.20(Predicted)
color :Yellow
Stability :Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
InChIKey :OGUCZBIQSYYWEF-UHFFFAOYSA-N

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Danger
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H301 Toxic if swalloed Acute toxicity,oral Category 3 Danger GHS hazard pictograms P264, P270, P301+P310, P321, P330,P405, P501
H336 May cause drowsiness or dizziness Specific target organ toxicity,single exposure; Narcotic effects Category 3 Warning P261, P271, P304+P340, P312,P403+P233, P405, P501
Precautionary statements:

Description

Clozapine is an atypical anti-psychotic compound that modulates a range of neurological receptors. Clozapine N-oxide is a major metabolite of clozapine that can be detected in the earliest excretion time interval after clozapine administration. It is produced by the action of cytochrome P450 (CYP) isoforms CYP1A2 and CYP3A4, whose activities, in turn, can be affected by drugs and disease. Clozapine N-oxide is normally biologically inactive. However, it can be used in designer receptor exclusively activated by designer drug, also known as DREADD, technology to modulate synthetic receptors in vivo.

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