4-Nitrophthalic anhydride
- CAS No.
- 5466-84-2
- Chemical Name:
- 4-Nitrophthalic anhydride
- Synonyms
- 4-nitro-anhydride;TIMTEC-BB SBB008431;Apremilast Impurity 89;4-nitro-phthalicanhydrid;p-NitroPhthalicAnhydride;4-NITROPHTHALIC ANHYDRIDE;5-Nitrophthalic anhydride;4-nitro pthalic anhydride;4-NitrophthalicAnhydride>4-Nitrophthalicanhydride,95%
- CBNumber:
- CB6207807
- Molecular Formula:
- C8H3NO5
- Molecular Weight:
- 193.11
- MOL File:
- 5466-84-2.mol
- MSDS File:
- SDS
- Modify Date:
- 2023/4/23 13:52:06
| Melting point | 116-120 °C(lit.) |
|---|---|
| Boiling point | 197 °C / 8mmHg |
| Density | 1.6392 (rough estimate) |
| refractive index | 1.4700 (estimate) |
| storage temp. | Inert atmosphere,Room Temperature |
| solubility | Acetone (Slightly), Chloroform (Slightly), Methanol (Slightly) |
| form | Solid |
| color | Pale Beige |
| Water Solubility | Hydrolysis |
| Sensitive | Moisture Sensitive |
| BRN | 179682 |
| CAS DataBase Reference | 5466-84-2(CAS DataBase Reference) |
| NIST Chemistry Reference | 4-Nitrophthalic anhydride(5466-84-2) |
| EPA Substance Registry System | 5-Nitrophthalic anhydride (5466-84-2) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P264-P271-P280-P302+P352-P305+P351+P338 | |||||||||
| Hazard Codes | Xi,Xn | |||||||||
| Risk Statements | 36/37/38-20/22 | |||||||||
| Safety Statements | 26-36-36/37/39-22 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | TI3328000 | |||||||||
| F | 10-21 | |||||||||
| TSCA | Yes | |||||||||
| HS Code | 29173990 | |||||||||
| NFPA 704 |
|
4-Nitrophthalic anhydride price More Price(6)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | 238201 | 4-Nitrophthalic anhydride 92% | 5466-84-2 | 5G | ₹3200 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 238201 | 4-Nitrophthalic anhydride 92% | 5466-84-2 | 25G | ₹10080 | 2022-06-14 | Buy |
| TCI Chemicals (India) | N0246 | 4-Nitrophthalic Anhydride min. 98.0 % | 5466-84-2 | 25G | ₹10700 | 2022-05-26 | Buy |
| ALFA India | ALF-L08020-14 | 4-Nitrophthalic anhydride, tech. 90% | 5466-84-2 | 25g | ₹11957 | 2022-05-26 | Buy |
| TCI Chemicals (India) | N0246 | 4-Nitrophthalic Anhydride min. 98.0 % | 5466-84-2 | 100G | ₹21000 | 2022-05-26 | Buy |
4-Nitrophthalic anhydride Chemical Properties,Uses,Production
Chemical Properties
off-white to light yellow-brown powder. Soluble in hot alcohol, hot acetic acid and acetone, insoluble in water.
Uses
4-Nitrophthalic anhydride is used an an intermediate for the synthesis of a benzimidazole PARP inhibitor I (succinate salt) (ABT-472).
Preparation
4-Nitrophthalic anhydride is synthesized by hydrolysis of 4-nitrophthalimide and then dehydration. The 4-nitrophthalimide was added to the sodium hydroxide solution, heated and boiled for 15min. Adjust pH to 6-8 with nitric acid, and add nitric acid to boil for 5 min. Cooling, filtering, the filtrate was extracted with ether, the extract was dried and then the ether was evaporated, that is, 4-Nitrophthalic anhydride crystals were precipitated. Yield 95%.
General Description
Yellow powder.
Air & Water Reactions
Reacts with water. The organic acids produced by this reaction are significantly more soluble in water.
Reactivity Profile
4-Nitrophthalic anhydride reacts exothermically with water. The reactions are usually slow, but might become violent if local heating accelerates their rate. Acids accelerate the reaction with water. Incompatible with acids, strong oxidizing agents, alcohols, amines, and bases.
Fire Hazard
Flash point data for 4-Nitrophthalic anhydride are not available, however 4-Nitrophthalic anhydride is probably combustible.
Purification Methods
Distil the anhydride in a vacuum and/or recrystallise it from *C6H6 or Et2O/pet ether. Dry it in vacuo. It forms addition compounds with anthracene (m 118o), and phenanthrene (m 96o). [Beilstein 17 III/IV 6150, 17/11 V 267.]
4-Nitrophthalic anhydride Preparation Products And Raw materials
Raw materials
Preparation Products
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chevron_right| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| GLR Innovations | +91 9891111994 | New Delhi, India | 4542 | 58 | Inquiry |
| SynthoCascade Research Laboratories | +91-9440962500 +91-9440962500 | Telangana, India | 284 | 58 | Inquiry |
| OCEAN TRADING CORPORATION | +91(22) 24921669 | New Delhi, India | 6211 | 58 | Inquiry |
| CHEMSWORTH | +91-261-2397244 | New Delhi, India | 6707 | 30 | Inquiry |
| A.J Chemicals | 91-9810153283 | New Delhi, India | 6124 | 58 | Inquiry |
| CLEARSYNTH LABS LTD. | +91-22-45045900 | Hyderabad, India | 6351 | 58 | Inquiry |
| Alfa Aesar | 1 800 209 7001 | Maharashtra, India | 6913 | 58 | Inquiry |
| TCI Chemicals (India) Pvt. Ltd. | 1800 425 7889 | New Delhi, India | 6778 | 58 | Inquiry |
| Asia Chem I and E (Jiangsu) Co Ltd | +8615105181882 | China | 129 | 58 | Inquiry |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | China | 21673 | 55 | Inquiry |
| Supplier | Advantage |
|---|---|
| GLR Innovations | 58 |
| SynthoCascade Research Laboratories | 58 |
| OCEAN TRADING CORPORATION | 58 |
| CHEMSWORTH | 30 |
| A.J Chemicals | 58 |
| CLEARSYNTH LABS LTD. | 58 |
| Alfa Aesar | 58 |
| TCI Chemicals (India) Pvt. Ltd. | 58 |
| Asia Chem I and E (Jiangsu) Co Ltd | 58 |
| Henan Tianfu Chemical Co.,Ltd. | 55 |