n-Docosanol
- CAS No.
- 661-19-8
- Chemical Name:
- n-Docosanol
- Synonyms
- BEHENYL ALCOHOL;DOCOSANOL;Behenic alcohol;1-DOCOSANOL;Docosan-1-ol;BEHENYLIC ALCOHOL;ik2;lidavol;tadenan;JARCOL 22
- CBNumber:
- CB6219657
- Molecular Formula:
- C22H46O
- Molecular Weight:
- 326.6
- MOL File:
- 661-19-8.mol
- Modify Date:
- 2024/6/24 22:20:23
| Melting point | 65-72 °C(lit.) |
|---|---|
| Boiling point | 180 °C0.22 mm Hg(lit.) |
| Density | d75 0.8063 g/ml; d85 0.7986 g/ml; d95 0.7911 g/ml |
| vapor pressure | 0Pa at 25℃ |
| refractive index | n75 1.4360 |
| storage temp. | Store below +30°C. |
| solubility | Chloroform (Slightly), Ethyl Acetate (Slightly) |
| pka | 15.20±0.10(Predicted) |
| form | Pellets or Tablets |
| color | White |
| Water Solubility | Insoluble |
| Merck | 13,3433 |
| BRN | 1770470 |
| Stability | Stable. Combustible. Incompatible with strong oxidizing agents. |
| LogP | 8.3 at 20℃ |
| CAS DataBase Reference | 661-19-8(CAS DataBase Reference) |
| NIST Chemistry Reference | 1-Docosanol(661-19-8) |
| EPA Substance Registry System | 1-Docosanol (661-19-8) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS07,GHS09 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H410-H319 | |||||||||
| Precautionary statements | P273-P391-P501-P264-P280-P305+P351+P338-P337+P313P | |||||||||
| Safety Statements | 24/25 | |||||||||
| WGK Germany | - | |||||||||
| RTECS | JR1315000 | |||||||||
| TSCA | Yes | |||||||||
| HS Code | 29051900 | |||||||||
| Toxicity | LD50 intraperitoneal in mouse: > 800mg/kg | |||||||||
| NFPA 704 |
|
n-Docosanol price More Price(7)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | PHR2264 | Docosanol (n-Docosanol) Pharmaceutical Secondary Standard; Certified Reference Material | 661-19-8 | 1G | ₹15306.55 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 8.22047 | 1-Docosanol for synthesis | 661-19-8 | 100G | ₹5130 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 169102 | 1-Docosanol 98% | 661-19-8 | 50G | ₹3150.08 | 2022-06-14 | Buy |
| TCI Chemicals (India) | D0964 | 1-Docosanol min. 98.0 % | 661-19-8 | 25G | ₹2400 | 2022-05-26 | Buy |
| TCI Chemicals (India) | D0964 | 1-Docosanol min. 98.0 % | 661-19-8 | 500G | ₹13300 | 2022-05-26 | Buy |
n-Docosanol Chemical Properties,Uses,Production
Chemical Properties
1-DOCOSANOL is white powder
Uses
n-Docosanol is a binder and an emulsion stabilizer. It is also used to increase a formulation’s viscosity. This is a mixture of fatty alcohols. behenyl alcohol may be used for any number of purposes in a cosmetic formulation, including as an emollient, a binder, an emulsion stabilizer, or to increase a product’s viscosity. It may be derived either synthetically or from plants.
Indications
Docosanol (Abreva) is a long-chain saturated alcohol
that is clinically effective against HSV. It has in vitro activity
against many enveloped viruses, including CMV,
influenzavirus, and respiratory syncytial virus.
Docosanol is not directly virucidal; instead, it blocks
the entry of the virion into the host cell by inhibiting the
fusion of the viral envelope with the host plasma membrane.
Because it does not affect viral replication or protein
production, it may be less susceptible to the development
of resistance than other antiviral drugs.
Definition
1-DOCOSANOL is a long-chain, saturated fatty alcohol.
General Description
1-Docosanol inhibits replication of certain viruses (herpes simplex virus and respiratory syncytial virus) within primary target cells in vitro. It has been isolated from Clematis brevicaudata.
Pharmaceutical Applications
1-DOCOSANOL is a 22-carbon straight chain alcohol licensed for over-thecounter sales for the topical treatment of herpes labialis. It is thought to act by blocking viral fusion with the host cell, although definitive studies are lacking. The clinical relevance of the antiviral activity has been debated and the place of this medication as a treatment of herpes labialis remains to be established.
Clinical Use
Docosanol cream is approved for the over-the-counter treatment of herpes labialis. It shortens the duration of symptoms of cold sores and fever blisters but does not provide symptomatic relief.
Side effects
Adverse effects of docosanol are minimal. Skin irritation occurs infrequently. Drug interactions are not anticipated.
Purification Methods
Crystallise docosanol from ether or chloroform/ether. [Beilstein 1 IV 1906.]
n-Docosanol Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| SKVen Technologies Pvt.Ltd. | +91-7032295152 +91-7032295152 | Hyderabad, India | 81 | 58 | Inquiry |
| Laxai Life Sciences | +91-4023480125 +91-4023480125 | Hyderabad, India | 21 | 58 | Inquiry |
| Esteem Industries Pvt. Ltd. | +91-8326613321 +91-8669968881 | Mumbai, India | 85 | 58 | Inquiry |
| Biophore India Pharmaceuticals Pvt Ltd | +91-9100031592 +91-9030907714 | Telangana, India | 134 | 58 | Inquiry |
| Godrej Industries Ltd | +919820305315 | Maharashtra, India | 41 | 58 | Inquiry |
| Maithri Drugs Pvt Ltd | +91-9059204566 +91-9848881740 | Telangana, India | 64 | 58 | Inquiry |
| AKASH PHARMA EXPORTS | +91-9388123451 +91-9846039283 | Kerela, India | 470 | 58 | Inquiry |
| BIOPHORE INDIA PHARMACEUTICALS PVT LTD | +91-4047474545 | New Delhi, India | 105 | 58 | Inquiry |
| AUROBINDO PHARMA LTD | +91 (40) 6672 1200 | New Delhi, India | 209 | 58 | Inquiry |
| MAITHRI DRUGS PRIVATE LTD | +91 40 30438600 | New Delhi, India | 29 | 58 | Inquiry |
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