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ChemicalBook > Product Catalog >Biochemical Engineering >Inhibitors >Metabolism >Transferase Inhibitors >(E)-N-[4-(1-BENZOYL-PIPERIDIN-4-YL)-BUTYL]-3-PYRIDIN-3-YL-ACRYLAMIDE

(E)-N-[4-(1-BENZOYL-PIPERIDIN-4-YL)-BUTYL]-3-PYRIDIN-3-YL-ACRYLAMIDE

(E)-N-[4-(1-BENZOYL-PIPERIDIN-4-YL)-BUTYL]-3-PYRIDIN-3-YL-ACRYLAMIDE Structure
CAS No.
658084-64-1
Chemical Name:
(E)-N-[4-(1-BENZOYL-PIPERIDIN-4-YL)-BUTYL]-3-PYRIDIN-3-YL-ACRYLAMIDE
Synonyms
FK867;FK 866;CS-973;APO-866;K 22.175;Daporinad;FK866, >=98%;(E)-Daporinad;FK866 (APO866);FK866 (Daporinad)
CBNumber:
CB62454096
Molecular Formula:
C24H29N3O2
Molecular Weight:
391.51
MOL File:
658084-64-1.mol
MSDS File:
SDS
Modify Date:
2023/6/8 9:02:11
Request For Quotation

(E)-N-[4-(1-BENZOYL-PIPERIDIN-4-YL)-BUTYL]-3-PYRIDIN-3-YL-ACRYLAMIDE Properties

Boiling point 629.9±51.0 °C(Predicted)
Density 1.131
storage temp. -20°C
solubility DMSO: soluble10mg/mL, clear
pka 14.12±0.46(Predicted)
form Yellow liquid
color white to beige
InChIKey KPBNHDGDUADAGP-VAWYXSNFSA-N

SAFETY

Risk and Safety Statements

Symbol(GHS) 
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H335
Precautionary statements  P261-P305+P351+P338
Hazard Codes  Xn
Risk Statements  22
WGK Germany  3
HS Code  2933399990
NFPA 704
0
2 0

(E)-N-[4-(1-BENZOYL-PIPERIDIN-4-YL)-BUTYL]-3-PYRIDIN-3-YL-ACRYLAMIDE price More Price(3)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich(India) F8557 FK866 hydrochloride hydrate ≥98% (HPLC) 658084-64-1 5MG ₹15891.1 2022-06-14 Buy
Sigma-Aldrich(India) F8557 FK866 hydrochloride hydrate ≥98% (HPLC) 658084-64-1 25MG ₹62081.38 2022-06-14 Buy
Sigma-Aldrich(India) 481908 Nicotinamide Phosphoribosyltransferase Inhibitor, FK866 - CAS 658084-64-1 - Calbiochem The Nicotinamide Phosphoribosyltransferase Inhibitor, FK866, also referenced under CAS 658084-64-1, controls the biological activity of Nicotinamide P 658084-64-1 2MG ₹17840 2022-06-14 Buy
Product number Packaging Price Buy
F8557 5MG ₹15891.1 Buy
F8557 25MG ₹62081.38 Buy
481908 2MG ₹17840 Buy

(E)-N-[4-(1-BENZOYL-PIPERIDIN-4-YL)-BUTYL]-3-PYRIDIN-3-YL-ACRYLAMIDE Chemical Properties,Uses,Production

Description

FK-866 is a highly specific non-competitive inhibitor of Nampt (Ki = 0.4 nM), causing gradual NAD+ depletion. In HepG2 human liver carcinoma cells, NAD+ depletion by FK-866 directs delayed cell death by apoptosis (IC50 = ~1 nM). In normal human smooth muscle cells, FK-866 causes premature senescence, an effect that may be linked to decreased activity of the NAD+-dependent enzyme SIRT1. Also, FK-866 induces autophagy in SH-SY5Y neuroblastoma cells, as indicated by the formation of LC3-positive vesicles.

Uses

FK866 hydrochloride hydrate has been used:

  • to investigate its effects on intra-axonal NAD+ levels
  • to induce NAD+ depletion
  • to reduce the level of tumor necrosis factor-α (TNF-α), nicotinamide phosphoribosyltransferase (NAMPT) and interleukin-6 (IL-6) in the ischemic brain tissue

General Description

A cell-permeable pyridinylacrylamide compound that acts as a selective, allosteric NAPRT/NAMPT (nicotinamide phosphoribosyltransferase) inhibitor (Ki = 0.4 nM for the enzyme/substrate complex; Ki′ = 0.3 nM for the free enzyme), while exhibiting no effect toward NPRT (nicotinic acid phosphoribosyltransferase) activity (82% inhibition of NAPRT activity at 10 nM vs no inhibition of NPRT activity at 1 μM in K-562 extract). FK866 treatment is shown to induce cell death by depleting NAD+ (Cat. Nos. 481911 & 481915) in HepG2 and NIH-3T3 cultures (by >95% after 24 h treatment of 10 nM FK866), likewise the addition of exogenous NAD+ is demonstrated to rescue NIH-3T3 and SH-SY5Y from FK866-induced NAD+-depletion and cell death.

(E)-N-[4-(1-BENZOYL-PIPERIDIN-4-YL)-BUTYL]-3-PYRIDIN-3-YL-ACRYLAMIDE Preparation Products And Raw materials

Raw materials

Preparation Products

(E)-N-[4-(1-BENZOYL-PIPERIDIN-4-YL)-BUTYL]-3-PYRIDIN-3-YL-ACRYLAMIDE Suppliers

Global( 126)Suppliers
Supplier Tel Country ProdList Advantage Inquiry
A.J Chemicals 91-9810153283 New Delhi, India 6124 58 Inquiry
ATK CHEMICAL COMPANY LIMITED +undefined-21-51877795 China 32760 60 Inquiry
career henan chemical co +86-0371-86658258 +8613203830695 China 29897 58 Inquiry
BOC Sciences +1-631-485-4226 United States 19553 58 Inquiry
Chongqing Chemdad Co., Ltd +86-023-6139-8061 +86-86-13650506873 China 39916 58 Inquiry
TargetMol Chemicals Inc. +1-781-999-5354 +1-00000000000 United States 19892 58 Inquiry
Dideu Industries Group Limited +86-29-89586680 +86-15129568250 China 24607 58 Inquiry
InvivoChem +1-708-310-1919 +1-13798911105 United States 6393 58 Inquiry
LEAP CHEM CO., LTD. +86-852-30606658 China 24738 58 Inquiry
ShenZhen Trendseen Biological Technology Co.,Ltd. 13417589054 China 11681 58 Inquiry
Supplier Advantage
A.J Chemicals 58
ATK CHEMICAL COMPANY LIMITED 60
career henan chemical co 58
BOC Sciences 58
Chongqing Chemdad Co., Ltd 58
TargetMol Chemicals Inc. 58
Dideu Industries Group Limited 58
InvivoChem 58
LEAP CHEM CO., LTD. 58
ShenZhen Trendseen Biological Technology Co.,Ltd. 58

(E)-N-[4-(1-BENZOYL-PIPERIDIN-4-YL)-BUTYL]-3-PYRIDIN-3-YL-ACRYLAMIDE Spectrum

(E)-N-[4-(1-BENZOYL-PIPERIDIN-4-YL)-BUTYL]-3-PYRIDIN-3-YL-ACRYLAMIDE(658084-64-1)1HNMR

658084-64-1((E)-N-[4-(1-BENZOYL-PIPERIDIN-4-YL)-BUTYL]-3-PYRIDIN-3-YL-ACRYLAMIDE)Related Search:

Benoxinate Hydrochloride 6-CHLORO-2,3,4,9-TETRAHYDRO-1H-CARBAZOLE-1-CARBOXAMIDE Dabrafenib Trametinib Crizotinib
Irinotecan Olaparib FK866 (APO866, Daporinad)
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(E)-N-[4-(1-BENZOYL-PIPERIDIN-4-YL)-BUTYL]-3-PYRIDIN-3-YL-ACRYLAMIDE 2-PROPENAMIDE, N-[4-(1-BENZOYL-4-PIPERIDINYL)BUTYL]-3-(3-PYRIDINYL)-, (2E)- APO-866 K 22.175 (2E)-N-[4-(1-Benzoyl-4-piperidinyl)butyl]-3-(3-pyridinyl)-2-propenamide FK 866 FK866 (APO866) FK866, >=98% FK866 (APO866, Daporinad) Daporinad (2E)-N-[4-(1-Benzoyl-4-piperidinyl)butyl]-3-(3-pyridinyl)-2-propenamide APO 866 FK 866 APO 866 FK 866 FK866 hydrochloride hydrate FK866 (Daporinad) FK 866 hydrochloride Nicotinamide Phosphoribosyltransferase Inhibitor, FK866 Daporinad (FK866) FK867 APO866, Daporinad (E)-Daporinad Nicotinamide Phosphoribosyltransferase Inhibitor, FK866 - CAS 658084-64-1 - Calbiochem FK 866 - Daporinad | APO 866 FK 866 hydrochloride - K 22.175 hydrochloride FK-866;AP-O866;FK 866;AP O866 CS-973 Daporinad(FK866,APO866) (E)-N-[4-(1-BENZOYL-PIPERIDIN-4-YL)-BUTYL]-3-PYRIDIN-3-YL-ACRYLAMIDE USP/EP/BP Daporinad (APO866) inhibit,Visfatin,(E) Daporinad,Autophagy,Nicotinamide phosphoribosyl transferase,NAMPT,APO-866,PBEF,FK 866,Inhibitor,Pre-B cell colony enhancing factor,APO 866,(E)-Daporinad,FK-866,(E)Daporinad (2E)-N-4-(1-Benzoyl-piperidin-4-yl)butyl-3-(pyridin-3-yl)-acrylamide 658084-64-1 568084-64-1 Inhibitors Inhibitor