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pf-5274857

pf-5274857 Structure
CAS No.
1373615-35-0
Chemical Name:
pf-5274857
Synonyms
CS-601;pf-5274857;PF-5274857 freebase;pf-5274857 USP/EP/BP;PF5274857;PF 5274857;PF-5274857 hydrochloride;PF-5274857;PF 5274857;PF5274857;1-(4-(5-Chloro-4-(3,5-dimethylpyridin-2-yl)pyridin-2-yl)piperazin-1-yl)-3-(methylsulfonyl)prop;1-[4-(5'-Chloro-3,5-dimethyl[2,4'-bipyridin]-2'-yl)-1-piperazinyl]-3-(methylsulfonyl)-1-propanone;1-(4-(5'-Chloro-3,5-dimethyl-[2,4'-bipyridin]-2'-yl)piperazin-1-yl)-3-(methylsulfonyl)propan-1-one
CBNumber:
CB62640301
Molecular Formula:
C20H25ClN4O3S
Molecular Weight:
436.96
MOL File:
1373615-35-0.mol
MSDS File:
SDS
Modify Date:
2023/9/20 16:43:00
Request For Quotation

pf-5274857 Properties

storage temp. Sealed in dry,Store in freezer, under -20°C
solubility H2O: soluble3mg/mL, clear (warmed)
form powder
color white to beige

SAFETY

Risk and Safety Statements

Symbol(GHS) 
GHS07
Signal word  Warning
Hazard statements  H317-H319
Precautionary statements  P280-P305+P351+P338
WGK Germany  3

pf-5274857 Chemical Properties,Uses,Production

Uses

PF-5274857 is a potent and selective Smoothened (Smo) antagonist, inhibits Hedgehog (Hh) signaling, respectively, and can penetrate the blood–brain barrier.

Enzyme inhibitor

This brain-penetrating Smoothened (Smo) antagonist (FW = 436.96 g/mol; CAS 1373615-35-0), also known as 1-(4-(5-chloro-4-(3,5-dimethylpyridin- 2-yl)pyridin-2-yl)piperazin-1-yl)-3-(methylsulfonyl)propan-1-one, potentlyand selectively inhibits Hedgehog (Hh) signaling (IC50 = 5.8 nM; Ki = 4.6 nM). PF-5274857 elicits robust antitumor activity in a mouse model of medulloblastoma (IC50 = 8.9 nmol/L), with down-regulation of Gli1, a marker closely linked to the tumor growth inhibition in patched (+/-) medulloblastoma mice. PF-5274857 also inhibits Smo activity within the brain of primary medulloblastoma mice, improving survival. PF-5274857 is orally available and metabolically stable in vivo. Other Hedgehog inhibitors include: GANT61, BMS-833923, Purmorphamine, SANT-1, LY2940680, Cyclopamine, LDE225 (or NVP-LDE225, Erismodegib), Vismodegib (GDC-0449)

pf-5274857 Preparation Products And Raw materials

Raw materials

Preparation Products

pf-5274857 Suppliers

Global( 82)Suppliers
Supplier Tel Country ProdList Advantage Inquiry
CLEARSYNTH LABS LTD. +91-22-45045900 Hyderabad, India 6351 58 Inquiry
A.J Chemicals 91-9810153283 New Delhi, India 6124 58 Inquiry
ATK CHEMICAL COMPANY LIMITED +undefined-21-51877795 China 32835 60 Inquiry
career henan chemical co +86-0371-86658258 +8613203830695 China 29899 58 Inquiry
Dideu Industries Group Limited +86-29-89586680 +86-15129568250 China 23430 58 Inquiry
Zhejiang J&C Biological Technology Co.,Limited +1-2135480471 +1-2135480471 China 10522 58 Inquiry
InvivoChem +1-708-310-1919 +1-13798911105 United States 6393 58 Inquiry
Nantong HI-FUTURE Biology Co., Ltd. +undefined18051384581 China 3136 58 Inquiry
TargetMol Chemicals Inc. +1-781-999-5354 United States 19973 58 Inquiry
Chemtour Biotech Co., Ltd +8617327281506 China 1460 58 Inquiry
Supplier Advantage
CLEARSYNTH LABS LTD. 58
A.J Chemicals 58
ATK CHEMICAL COMPANY LIMITED 60
career henan chemical co 58
Dideu Industries Group Limited 58
Zhejiang J&C Biological Technology Co.,Limited 58
InvivoChem 58
Nantong HI-FUTURE Biology Co., Ltd. 58
TargetMol Chemicals Inc. 58
Chemtour Biotech Co., Ltd 58

pf-5274857 Spectrum

pf-5274857(1373615-35-0)1HNMR

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pf-5274857 1-(4-(5-chloro-4-(3,5-diMethylpyridin-2-yl)pyridin-2-yl)piperazin-1-yl)-3-(Methylsulfonyl)propan-1-one 1-[4-(5′-Chloro-3,5-dimethyl-2,4′-bipyridin-2′-yl)piperazin-1-yl] -3- (methylsulfonyl)propan-1-one hydrochloride PF-5274857 hydrochloride 1-[4-(5'-Chloro-3,5-dimethyl[2,4'-bipyridin]-2'-yl)-1-piperazinyl]-3-(methylsulfonyl)-1-propanone 1-(4-(5-Chloro-4-(3,5-dimethylpyridin-2-yl)pyridin-2-yl)piperazin-1-yl)-3-(methylsulfonyl)prop PF5274857;PF 5274857 CS-601 PF-5274857;PF 5274857;PF5274857 1-Propanone, 1-[4-(5'-chloro-3,5-dimethyl[2,4'-bipyridin]-2'-yl)-1-piperazinyl]-3-(methylsulfonyl)- pf-5274857 USP/EP/BP PF-5274857 freebase 1-(4-(5'-Chloro-3,5-dimethyl-[2,4'-bipyridin]-2'-yl)piperazin-1-yl)-3-(methylsulfonyl)propan-1-one inhibit,driven,PF 5274857,PF5274857,metastasis,pathway,Smo,PF-5274857,Smoothened,Inhibitor,brain,tumor 1-(4-(5'-Chloro-3,5-dimethyl-[2,4'-bipyridin]-2'-yl)piperazin-1-yl)-3-(methylsulfonyl)propan-1-one 1373615-35-0 373615-35-0 73615-35-0 C20H25ClN4O3S Inhibitors