Ketorolac
- CAS No.
- 74103-06-3
- Chemical Name:
- Ketorolac
- Synonyms
- Ketorolac acid;Acular;Fluoxetin;(S)-Ketorolac;5-benzoyl-2,3-dihydro-1h-pyrrolizine-1-carboxylic acid;Dolac;rs37619;Lixidol;Tm-asyn;Toratex
- CBNumber:
- CB6392833
- Molecular Formula:
- C15H13NO3
- Molecular Weight:
- 255.27
- MOL File:
- 74103-06-3.mol
- Modify Date:
- 2024/6/13 17:03:25
| Melting point | 160-161°C |
|---|---|
| Boiling point | 493.2±40.0 °C(Predicted) |
| Density | 1.33±0.1 g/cm3(Predicted) |
| storage temp. | 2-8°C |
| solubility | Chloroform (Slightly), Methanol (Slightly) |
| form | Solid |
| pka | 3.49 ±0.02(at 25℃) |
| color | Off-White |
| Water Solubility | 183mg/L(32 ºC) |
| CAS DataBase Reference | 74103-06-3(CAS DataBase Reference) |
| EPA Substance Registry System | 1H-Pyrrolizine-1-carboxylic acid, 5-benzoyl-2,3-dihydro- (74103-06-3) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302-H315-H319-H332-H335 | |||||||||
| Precautionary statements | P261-P280-P305+P351+P338 | |||||||||
| RIDADR | 3249 | |||||||||
| HazardClass | 6.1(a) | |||||||||
| PackingGroup | II | |||||||||
| HS Code | 2933998090 | |||||||||
| Toxicity | LD50 orally in mice: ~200 mg/kg (Rooks) | |||||||||
| NFPA 704 |
|
Ketorolac Chemical Properties,Uses,Production
Chemical Properties
Light yellow solid
Uses
antiarrhythmic
Indications
Ketorolac (Toradol), an NSAID chemically related to indomethacin and tolmetin, is mainly used as an analgesic, not for the treatment of inflammatory disease. It is available in oral, parenteral, and topical formulations.
World Health Organization (WHO)
Ketorolac is a nonsteroidal anti-inflammatory agent used in the management of moderate to severe acute post-operative pain. It remains on the market in many countries with restrictions on its use.
Biological Functions
Ketorolac (Toradol) is an NSAID with very mild antiinflammatory and antipyretic activity. It is a potent analgesic for postoperative pain. Its efficacy is equivalent to that of low doses of morphine in the control of pain. For this reason it is often combined with opioids to reduce opioid dose and related side effects while providing adequate pain relief. It is also used to replace the opioids in some patients with opioid sensitivity. The mechanism of action of ketorolac involves the inhibition of COX and decreased formation of prostaglandins. However, some evidence exists that ketorolac may stimulate the release of endogenous opioids as a part of its analgesic activity.
General Description
Ketorolac tromethamine (Toradol), marketed as a mixture of(R)- and (S)-ketorolac enantiomers, is a potent NSAID analgesicindicated for the treatment of moderately severe, acutepain. It should be noted that the pharmacokinetic dispositionof ketorolac in humans is subject to marked enantioselectivity.Thus, it is important to monitor the individual blood levelsso an accurate assessment of its therapeutic action can bemade correctly. However, it should be noted that, beingone of the conventional NSAIDs with highest risk of GIcomplications, its administration should not exceed 5 days.
Ketorolac Preparation Products And Raw materials
Raw materials
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chevron_rightPreparation Products
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| Global Pharma | +91-9819994077 +91-9819994077 | Maharashtra, India | 34 | 58 | Inquiry |
| VASISTA LIFE SCIENCES PRIVATE LIMITED | +91-04029554774 +91-9010855544 | Hyderabad, India | 153 | 58 | Inquiry |
| VASUDHA PHARMA CHEM LIMITED | +91-91-4044763666 +91-9396659284 | Telangana, India | 102 | 58 | Inquiry |
| J S LABS | +91-7330612784 +91-7330612784 | Tamil Nadu, India | 160 | 58 | Inquiry |
| SAMSON ORGANICS | +91-8341971897 +91-8341971897 | Hyderabad, India | 15 | 58 | Inquiry |
| Vepan Pharmatech Pvt Ltd | +91-9908788828 +91-9966094448 | Telangana, India | 72 | 58 | Inquiry |
| HRV Global Life Sciences | +91-9820219686 +91-9820219686 | Telangana, India | 379 | 58 | Inquiry |
| Chempifine Chemicals | +91-2225667766 +91-2225667766 | Punjab, India | 144 | 58 | Inquiry |
| Ralington Pharma | +91-7948911722 +91-9687771722 | Gujarat, India | 1350 | 58 | Inquiry |
| Sanpra Synthesis Pvt. Ltd. | +91-4043460830 +91-9246161600 | AndhraPradesh, India | 49 | 58 | Inquiry |
| Supplier | Advantage |
|---|---|
| Global Pharma | 58 |
| VASISTA LIFE SCIENCES PRIVATE LIMITED | 58 |
| VASUDHA PHARMA CHEM LIMITED | 58 |
| J S LABS | 58 |
| SAMSON ORGANICS | 58 |
| Vepan Pharmatech Pvt Ltd | 58 |
| HRV Global Life Sciences | 58 |
| Chempifine Chemicals | 58 |
| Ralington Pharma | 58 |
| Sanpra Synthesis Pvt. Ltd. | 58 |
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