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oxametacin

oxametacin Structure
CAS No.
27035-30-9
Chemical Name:
oxametacin
Synonyms
Flogar;ABC-8/3;oxametacin;Oxametacine;oxamethacin;Indoxamic acid;1-(p-Chlorobenzoyl)-5-methoxy-2-methyl-1H-indole-3-acetohydroxamic acid;1-(4-Chlorobenzoyl)-5-methoxy-2-methyl-1H-indole-3-acetohydroxamic acid;1H-Indole-3-acetamide, 1-(4-chlorobenzoyl)-N-hydroxy-5-methoxy-2-methyl-;2-[1-(4-chlorobenzoyl)-5-methoxy-2-methyl-indol-3-yl]-N-hydroxy-acetamide
CBNumber:
CB6939025
Molecular Formula:
C19H17ClN2O4
Molecular Weight:
372.806
MOL File:
27035-30-9.mol
Modify Date:
2023/5/15 10:43:54
Request For Quotation

oxametacin Properties

Melting point 181-182° (dec)
Density 1.2671 (rough estimate)
refractive index 1.6800 (estimate)
solubility DMSO (Slightly), Methanol (Heated, Slightly)
form Solid
pka 9.00±0.20(Predicted)
color Crystals from dioxane

SAFETY

Risk and Safety Statements

Toxicity LD50 orally in rats: 96 mg/kg (De Martiis, U.S. patent)

oxametacin Chemical Properties,Uses,Production

Description

Oxametacine is prepared by the acylation of hydroxylamine with indomethacin acid chloride. Oxametacine at a dose of 100 mg is reported to be as effective as 50 mg of indomethacin in reducing pain and inflammation with a lower incidence of adverse effects.

Definition

ChEBI: A hydroxamic acid obtained by formal condensation of the carboxy group of indometacin with the amino group of hydroxylamine.

Trade name

Flogar (UCB, Belgium; ABC, Portugal).

Safety Profile

Poison by ingestion and intraperitoneal routes. An anti-inflammatory agent. When heated to decomposition it emits toxic fumes of Clí and NOx.

oxametacin Preparation Products And Raw materials

Raw materials

Thionyl chloride Hydroxylamine hydrochloride Indometacin

Preparation Products

oxametacin Suppliers

Global( 8)Suppliers
Supplier Tel Country ProdList Advantage Inquiry
TargetMol Chemicals Inc. +1-781-999-5354 +1-00000000000 United States 19892 58 Inquiry
Shanghai New Union Textra Import & Export Co., Ltd +861-348-227-9455 China 2752 60 Inquiry
CHEMICAL LAND21 82- 2 -783 - 8063 South Korea 6315 74 Inquiry
Lanospharma Laboratories Co.,Ltd 13440048448 China 6343 56 Inquiry
Shanghai Hao Zhun Biological Technology Co., Ltd. 15800340161 CHINA 6846 58 Inquiry
United States Biological 800.520.3011 or 781.639.5092 United States 6256 80 Inquiry
TargetMol Chemicals Inc. 4008200310 China 24017 58 Inquiry
Supplier Advantage
TargetMol Chemicals Inc. 58
Shanghai New Union Textra Import & Export Co., Ltd 60
CHEMICAL LAND21 74
Lanospharma Laboratories Co.,Ltd 56
Shanghai Hao Zhun Biological Technology Co., Ltd. 58
United States Biological 80
TargetMol Chemicals Inc. 58

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2-[1-(4-chlorobenzoyl)-5-methoxy-2-methyl-indol-3-yl]-N-hydroxy-acetamide 1-(4-Chlorobenzoyl)-5-methoxy-2-methyl-1H-indole-3-acetohydroxamic acid 1-(p-Chlorobenzoyl)-5-methoxy-2-methyl-1H-indole-3-acetohydroxamic acid ABC-8/3 Flogar Indoxamic acid oxametacin oxamethacin Oxametacine 1H-Indole-3-acetamide, 1-(4-chlorobenzoyl)-N-hydroxy-5-methoxy-2-methyl- 27035-30-9