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Mizolastine

CAS No.: 108612-45-9

Chemical Name:: Mizolastine

Synonyms: MKC 431;Mizollen;Zolistan;MistaMine;SL 850324;Mizostatin;MIZOLASTINE;Mizolastine>Mizolastine HCl;Mizolastine inn

CBNumber:: CB7150058

Molecular Formula:: C24H25FN6O

Molecular Weight:: 432.49

MOL File:: 108612-45-9.mol

Modify Date:: 2024/10/31 18:15:48

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Mizolastine Properties

Melting point	217°
Density	1.34±0.1 g/cm3(Predicted)
storage temp.	Refrigerator
solubility	Chloroform (Slightly, Heated), DMSO, Methanol (Slightly, Heated)
form	Solid
pka	9.73±0.40(Predicted)
color	White
Merck	14,6221

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H302-H312-H332
Precautionary statements	P280-P302+P352-P312-P322-P363-P501-P261-P271-P304+P340-P312-P264-P270-P301+P312-P330-P501
RTECS	UW7481284
HS Code	2933.39.9200

Mizolastine price More Price(2)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
TCI Chemicals (India)	M2756	Mizolastine	108612-45-9	1G	₹8300	2022-05-26	Buy
TCI Chemicals (India)	M2756	Mizolastine	108612-45-9	5G	₹15000	2022-05-26	Buy

Product number	Packaging	Price	Buy
M2756	1G	₹8300	Buy
M2756	5G	₹15000	Buy

Mizolastine Chemical Properties,Uses,Production

Description

Mizolastine was marketed in Germany and Switzerland as Mizollen for the symptomatic relief of seasonal and perennial allergic rhinoconjunctivitis and urticaria. Mizolastine is a new long-acting, orally active antihistaminic agent with a rapid onset of action ; the two most recent H1 antagonists launched were fexofenadine, metabolite of terfenadine (Sepracor, 1996) and Olopatadine (Kyowa Hakko, 1997). Mizolastine can be prepared in 2 steps from 2-chloro 1- (4-fluorobenzyl)benzimidazole by successive condensations of appropriate amine and thioether. Mizolastine selectively blocks the peripheral H1 receptors (but not the serotonergic, noradrenergic, muscarinic receptors) with a minimal occupancy of brain receptors, and therefore does not elicit any sedative effects. Moreover, Mizolastine does not produce cardiac rhythm disorders which have been associated with certain non-sedating antihistamines in humans.

Chemical Properties

White Solid

Uses

A highly selective histamine H1-receptor antagonist (with no anticholinergic, antiadrenergic, or antiserotonin activity) for use in the treatment of allergic disorders, especially rhinitis and urticaria.

Mizolastine Preparation Products And Raw materials

Raw materials

Preparation Products

Mizolastine Suppliers

Global( 277)Suppliers

Supplier	Tel	Country	ProdList	Advantage	Inquiry
Ralington Pharma	+91-7948911722 +91-9687771722	Gujarat, India	1350	58	Inquiry
Bal Pharma Limited	+91-8041379581 +91-8041379500	Karnataka, India	20	58	Inquiry
Rivashaa Agrotech Biopharma Pvt. Ltd.	+91-26463395 +91-7926462688	Gujarat, India	1615	58	Inquiry
OCEAN TRADING CORPORATION	+91(22) 24921669	New Delhi, India	6202	58	Inquiry
Medilink Pharmachem	+91 (79) 3007-0133	New Delhi, India	424	50	Inquiry
TCI Chemicals (India) Pvt. Ltd.	1800 425 7889	New Delhi, India	6768	58	Inquiry
Pharmaffiliates Analytics and Synthetics P. Ltd	+91-172-5066494	Haryana, India	6739	58	Inquiry
Angle Biopharma	08046067501	Ahmedabad, India	142	58	Inquiry
A.J Chemicals	91-9810153283	New Delhi, India	6100	58	Inquiry
CLEARSYNTH LABS LTD.	+91-22-45045900	Hyderabad, India	6257	58	Inquiry

Supplier	Advantage
Ralington Pharma	58
Bal Pharma Limited	58
Rivashaa Agrotech Biopharma Pvt. Ltd.	58
OCEAN TRADING CORPORATION	58
Medilink Pharmachem	50
TCI Chemicals (India) Pvt. Ltd.	58
Pharmaffiliates Analytics and Synthetics P. Ltd	58
Angle Biopharma	58
A.J Chemicals	58
CLEARSYNTH LABS LTD.	58

Mizolastine Spectrum

Mizolastine(108612-45-9)¹HNMR

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4(1h)-pyrimidinone,2-((1-(1-((4-fluorophenyl)methyl)-1h-benzimidazol-2-yl)-4-p iperidinyl)methylamino)- 2-[[1-[1-[(4-fluorophenyl)methyl]benzoimidazol-2-yl]-4-piperidyl]-methyl-amino]-3h-pyrimidin-4-one MIZOLASTINE 2-[[1-[1-[(4-fluorophenyl)methyl]-1H-benzimidazol-2-yl]-4-piperidinyl]methylamino]-4(1H)-pyrimidinone Mizolastine HCl 2-[[1-[1-(4-fluorobenzyl)benzimidazol-2-yl]-4-piperidyl]-methyl-amino]-1H-pyrimidin-6-one 2-[[1-[1-[(4-fluorophenyl)methyl]benzimidazol-2-yl]piperidin-4-yl]-methyl-amino]-1H-pyrimidin-6-one 2-[[1-[1-[(4-fluorophenyl)methyl]benzimidazol-2-yl]piperidin-4-yl]-methylamino]-1H-pyrimidin-6-one Mizolastine inn MistaMine Mizollen MKC 431 SL 850324 Zolistan 4(3H)-PyriMidinone,2-[[1-[1-[(4-fluorophenyl)Methyl]-1H-benziMidazol-2-yl]-4-piperidinyl]MethylaMino]- 2-((1-(1-(4-Fluorobenzyl)-1H-benzo[d]iMidazol-2-yl)piperidin-4-yl)(Methyl)aMino)pyriMidin-4(1H)-one 2-((1-(1-(4-Fluorobenzyl)-1H-benzo[d]imidazol-2-yl)-piperidin-4-yl)(methyl)amino)pyrimidin-4(1H)- Mizolastine (Mizollen) Mizolastine, >=99% 2-[{1-[1-(4-fluorobenzyl)-1H-benzimidazol-2-yl]piperidin-4-yl}(methyl)amino]pyrimidin-4(1H)-one 2-((1-(1-(4-Fluorobenzyl)-1H-benzo[d]imidazol-2-yl)-piperidin-4-yl)(methyl)amino)pyrimidin-4(1 2-[[1-[1-[(4-fluorophenyl)methyl]-2-benzimidazolyl]-4-piperidinyl]-methylamino]-1H-pyrimidin-6-one Mizolastine 4(1h)-pyrimidinone,2-((1-(1-((4-fluorophenyl)methyl)-1h-benzimidazol-2-yl)-4-p Mizolastine Mizolastine Mizolastine> Mizolastine USP/EP/BP Mizolastine zhou Mizolastine (SL 850324) Mizolastine 108612-45-9 2-[(1-{1-[(4-fluorophenyl)methyl]-1H-1,3-benzodiazol-2-yl}piperidin-4-yl)(methyl)amino]-3,4-dihydropyrimidin-4-one Imimidistine impurity Mizostatin Mizostatin/Mizostatin 108612-45-9 C24H25FN6O Other APIs Aromatics Heterocycles Inhibitors Intermediates & Fine Chemicals Pharmaceuticals Antihistaminic APIs