2-Amino-5-bromobenzoic acid
- CAS No.
- 5794-88-7
- Chemical Name:
- 2-Amino-5-bromobenzoic acid
- Synonyms
- 5-BROMOANTHRANILIC ACID;5-BROMO-2-AMINOBENZOIC ACID;BUTTPARK 89\07-49;RARECHEM AL BO 1183;5-bromo-anthranilicaci;2-Amino-5-bromobenzoic;5-Bromoantharanilic Acid;2-amino-5-bromo-benzoicaci;Anthranilic acid, 5-bromo-;2-AMINO-5-BROMOBENZOIC ACID
- CBNumber:
- CB7154465
- Molecular Formula:
- C7H6BrNO2
- Molecular Weight:
- 216.03
- MOL File:
- 5794-88-7.mol
- MSDS File:
- SDS
- Modify Date:
- 2024/1/25 16:49:20
| Melting point | 213-215 °C (lit.) |
|---|---|
| Boiling point | 265.51°C (rough estimate) |
| Density | 1.6841 (rough estimate) |
| refractive index | 1.6120 (estimate) |
| storage temp. | Keep in dark place,Inert atmosphere,Room temperature |
| solubility | Soluble in methanol and dimethyl sulfoxide. |
| pka | 4.55±0.10(Predicted) |
| form | Powder |
| color | Beige |
| Sensitive | Light Sensitive |
| Merck | 14,1405 |
| BRN | 639028 |
| InChI | InChI=1S/C7H6BrNO2/c8-4-1-2-6(9)5(3-4)7(10)11/h1-3H,9H2,(H,10,11) |
| InChIKey | CUKXRHLWPSBCTI-UHFFFAOYSA-N |
| SMILES | C(O)(=O)C1=CC(Br)=CC=C1N |
| CAS DataBase Reference | 5794-88-7(CAS DataBase Reference) |
| NIST Chemistry Reference | 2-Amino-5-bromobenzoic acid(5794-88-7) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS06 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H301-H315-H319-H335 | |||||||||
| Precautionary statements | P261-P264-P270-P301+P310-P302+P352-P305+P351+P338 | |||||||||
| Hazard Codes | Xn | |||||||||
| Risk Statements | 22-36/37 | |||||||||
| Safety Statements | 26-38-36/37 | |||||||||
| RIDADR | UN 2811 6.1/PG 3 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | CB2557670 | |||||||||
| Hazard Note | Harmful | |||||||||
| PackingGroup | 6.1/PG 3 | |||||||||
| HS Code | 29224999 | |||||||||
| NFPA 704 |
|
2-Amino-5-bromobenzoic acid price More Price(7)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | 260118 | 2-Amino-5-bromobenzoic acid 97% | 5794-88-7 | 5G | ₹2565.53 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 260118 | 2-Amino-5-bromobenzoic acid 97% | 5794-88-7 | 25G | ₹6982.13 | 2022-06-14 | Buy |
| ALFA India | ALF-A11915-22 | 2-Amino-5-bromobenzoic acid, 98% | 5794-88-7 | 100g | ₹31835 | 2022-05-26 | Buy |
| ALFA India | ALF-A11915-14 | 2-Amino-5-bromobenzoic acid, 98% | 5794-88-7 | 25g | ₹7600 | 2022-05-26 | Buy |
| TCI Chemicals (India) | A1254 | 2-Amino-5-bromobenzoic Acid | 5794-88-7 | 5G | ₹2700 | 2022-05-26 | Buy |
2-Amino-5-bromobenzoic acid Chemical Properties,Uses,Production
Chemical Properties
slight yellow to white powder
Physical properties
2-Amino-5-bromobenzoic acid has 17 atoms, meaning 45 vibrational modes in three main parts: Carboxyl group, amine group, and benzene. The molecule's most mechanically active parts are the carboxyl and amine groups. They exhibit rocking, swinging, and every kind of mechanical motion beside H immigrations between each other. For this reason, the molecule is not a simple carboxylic acid nor a primary amine[1].
Uses
2-Amino-5-bromobenzoic acid is a brominated derivative of Antharilinic Acid (A679222). 2-Amino-5-bromobenzoic acid displays plant growth-regulator activity. 2-Amino-5-bromobenzoic acid is used in the preparation of hepatitis C virus NS5b RNA polymerase inhibitors.
Preparation
2-Amino-5-bromobenzoic acid is synthesized from o-aminobenzoic acid by bromination.
Synthesis of 2-amino-5-bromobenzoic acid (4c, CAS: 5794-88-7) and 2-amino3,5-dibromobenzoic acid (4d, CAS: 609-85-8): A solution of bromine (7.2 g, 2 mL, 40 mmol) in 47 mL glacial acetic acid was added dropwise to sodium 2-aminobenzoate (6.4 g, 40 mmol) in 32 mL of glacial acetic acid at 15 °С and the mixture was stirred for 1 h at the same temperature. The product was filtered off, washed with benzene and dried in the dark. The bromobenzoic acids containing mixture (0.5 g) was added to 10 mL of boiling water followed by the addition of 1.3 mL of concentrated hydrochloric acid and hot filtration under vacuum. The insoluble material contained 2-amino-3,5-dibromobenzoic acid, whereas 2- amino-5-bromobenzoic acid precipitated upon cooling of the filtrate.
2-Amino-5-bromobenzoic acid (4c) IR (suspension in nujol, cm?1 ): 3497, 3383, 1675, 1616, 1587, 1548, 1423, 1377, 1316, 1292, 1239, 1160, 1127, 812, 748, 691.
References
[1] Kunduracioglu, Ahmet . "Tautomeric Forms of 2–Amino–5–Bromobenzoic Acid: A DFT Study for Structural and Molecular Orbital Analysis." (2021).
2-Amino-5-bromobenzoic acid Preparation Products And Raw materials
Raw materials
1of3
chevron_rightPreparation Products
1of2
chevron_right| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| BTC pharm India | +918790379245 | AndhraPradesh, India | 1269 | 58 | Inquiry |
| GLR Innovations | +91 9891111994 | New Delhi, India | 4542 | 58 | Inquiry |
| Vignasai Laboratories Pvt Ltd | +91-9390048212 +91-9030998889 | Telangana, India | 99 | 58 | Inquiry |
| SVH BIOSCIENCES | +91-6303499280 +91-6303499280 | Hyderabad, India | 478 | 58 | Inquiry |
| Syn Finechem Laboratories Pvt Ltd | +91-4023095094 +91-9848230784 | Telangana, India | 194 | 58 | Inquiry |
| Hyderabad | +91-9676447615 +91-9676447615 | Telangana, India | 192 | 58 | Inquiry |
| Ergam Life Sciences Pvt. Ltd. | +91-8125300959 +91-08125300959 | Telangana, India | 68 | 58 | Inquiry |
| VGS SYNTHESIS PRIVATE LIMITED | +91-9866975588 +91-9866975588 | Hyderabad, India | 1818 | 58 | Inquiry |
| REDDY N REDDY PHARMACEUTICALS | +91-9848096759 +91-9848096759 | Hyderabad, India | 1989 | 58 | Inquiry |
| CHEMAZON LABORATORIES | +91 9848551964 | Hyderabad, India | 1320 | 58 | Inquiry |
| Supplier | Advantage |
|---|---|
| BTC pharm India | 58 |
| GLR Innovations | 58 |
| Vignasai Laboratories Pvt Ltd | 58 |
| SVH BIOSCIENCES | 58 |
| Syn Finechem Laboratories Pvt Ltd | 58 |
| Hyderabad | 58 |
| Ergam Life Sciences Pvt. Ltd. | 58 |
| VGS SYNTHESIS PRIVATE LIMITED | 58 |
| REDDY N REDDY PHARMACEUTICALS | 58 |
| CHEMAZON LABORATORIES | 58 |