Triisopropylsilane
- CAS No.
- 6485-79-6
- Chemical Name:
- Triisopropylsilane
- Synonyms
- TIPS;TIS;TIPS-H;Triisopropylsilane(L);PD-Tips;Three isopropylsilane;Triisopropylsilane 99%;DK854;DKSI023;HandyStep
- CBNumber:
- CB7208472
- Molecular Formula:
- C9H22Si
- Molecular Weight:
- 158.36
- MOL File:
- 6485-79-6.mol
- MSDS File:
- SDS
- Modify Date:
- 2024/10/31 13:32:20
| Boiling point | 84-86 °C/35 mmHg (lit.) |
|---|---|
| Density | 0.773 g/mL at 25 °C (lit.) |
| refractive index |
n |
| Flash point | 99 °F |
| storage temp. | Store below +30°C. |
| solubility | Benzene (Soluble), Chloroform (Soluble) |
| form | liquid |
| Specific Gravity | 0.773 |
| color | colorless |
| Water Solubility | Immiscible with water. |
| Sensitive | Moisture Sensitive |
| Hydrolytic Sensitivity | 3: reacts with aqueous base |
| BRN | 1733718 |
| InChIKey | YDJXDYKQMRNUSA-UHFFFAOYSA-N |
| CAS DataBase Reference | 6485-79-6(CAS DataBase Reference) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS02 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H226 | |||||||||
| Precautionary statements | P210-P233-P240-P241-P242-P243 | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 10-36/37/38 | |||||||||
| Safety Statements | 26-36-37/39-16 | |||||||||
| RIDADR | UN 1993 3/PG 3 | |||||||||
| WGK Germany | 3 | |||||||||
| F | 10-21 | |||||||||
| TSCA | No | |||||||||
| HS Code | 2931 90 00 | |||||||||
| HazardClass | 3 | |||||||||
| PackingGroup | III | |||||||||
| NFPA 704 |
|
Triisopropylsilane price More Price(10)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | 233781 | Triisopropylsilane 98% | 6485-79-6 | 10G | ₹5109.4 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 233781 | Triisopropylsilane 98% | 6485-79-6 | 50G | ₹9872.4 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 8.41359 | Triisopropylsilane for synthesis | 6485-79-6 | 10ML | ₹10880 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 233781 | Triisopropylsilane 98% | 6485-79-6 | 250G | ₹22375.28 | 2022-06-14 | Buy |
| TCI Chemicals (India) | T1533 | Triisopropylsilane min. 98.0 % | 6485-79-6 | 5ML | ₹2300 | 2022-05-26 | Buy |
Triisopropylsilane Chemical Properties,Uses,Production
Chemical Properties
Clear colorless liquid
Uses
Triisopropylsilane is used as a protecting group in peptide synthesis and is also used as a reducing agent for the selective reduction of anomeric C-phenyl ketals. It is used in the selective silylation of primary hydroxyl groups without affecting the secondary hydroxyl group. It is used in the preparation of anti-1,2-diols catalyzed by a Ni(O) N-heterocyclic carbine complex with high diastereoselectivity.
Reactivity Profile
Hindered hydrosilanes such as triisopropylsilane (TIS) are commonly used as cation scavengers in the deprotection of amino acid side-chains following solid‐phase peptide synthesis (SPPS). Protecting groups such as trityl (Trt) and tert‐butyl (But ) form stable cations upon acidolysis and are easily removed from N‐, O‐, and S‐containing amino acid side‐chains (for cysteine (Cys) But is not easily removed). In acid, TIS drives the equilibrium towards cleavage of the protecting group from the amino acid side chain by donating a hydride to the resulting cation in an irreversible manner. Although TIS and other hindered hydrosilanes are exclusively thought of as protecting group scavengers in SPPS, they are actually mild reducing agents. They can reduce a carbon‐heteroatom bond and can, therefore, directly participate in the removal of a protecting group from an amino acid side‐chain[1].
References
[1] Emma J. Ste.Marie, Robert J. Hondal. “Reduction of cysteine-S-protecting groups by triisopropylsilane.” Journal of Peptide Science 24 11 (2018).
Triisopropylsilane Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| Vardhaman P Golechha | 9704422000 | Telangana, India | 292 | 58 | Inquiry |
| Covalent Incorporation | +91-9033666099 +91-9033666099 | Gujarat, India | 50 | 58 | Inquiry |
| CLEARSYNTH LABS LTD. | +91-22-45045900 | Hyderabad, India | 6257 | 58 | Inquiry |
| TCI Chemicals (India) Pvt. Ltd. | 1800 425 7889 | New Delhi, India | 6768 | 58 | Inquiry |
| Alfa Aesar | 1 800 209 7001 | Maharashtra, India | 6905 | 58 | Inquiry |
| Hoxland Corporation | 07942559144 | Haryana, India | 20 | 58 | Inquiry |
| Jiangsu Vcan Advanced Material Co., Ltd. | +86-17306299870 +86-18652789875 | China | 38 | 58 | Inquiry |
| Shanghai Zhuangming Biopharma Co., Ltd. | +86-19189228086 +86-18858568638 | China | 643 | 58 | Inquiry |
| Shanghai Daken Advanced Materials Co.,Ltd | +86-371-66670886 | China | 18750 | 58 | Inquiry |
| Hebei Yanxi Chemical Co., Ltd. | +8617531153977 | China | 5857 | 58 | Inquiry |
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