Isoproterenol
- CAS No.
- 7683-59-2
- Chemical Name:
- Isoproterenol
- Synonyms
- isoprenaline;A 21;isoprel;Aludrin;asmalar;Aludrine;NSC 9975;Lomupren;Aleudrine;ICI 46399
- CBNumber:
- CB3854910
- Molecular Formula:
- C11H17NO3
- Molecular Weight:
- 211.26
- MOL File:
- 7683-59-2.mol
- MSDS File:
- SDS
- Modify Date:
- 2022/12/21 16:56:50
| Melting point | 170.5°C |
|---|---|
| Boiling point | 350.94°C (rough estimate) |
| Density | 1.1240 (rough estimate) |
| refractive index | 1.5718 (estimate) |
| pka | 8.64(at 25℃) |
| NIST Chemistry Reference | 3,4-Dihydroxy-«alpha»-(isopropylaminomethyl)-benzyl alcohol(7683-59-2) |
Isoproterenol Chemical Properties,Uses,Production
Description
Isoproterenol is a representative of the sympathomimetic drugs with high selectivity to β- adrenoreceptors. As was already noted, the addition to compounds of a bulky iso-propyl or tert-butyl group at the nitrogen atom of the β-phenylethylamino skeleton is associated with higher affinity to β-adrenergic receptive regions than to α-adrenergic. Isoproterenol is devoid of significant α-adrenergic agonistic action. Activation of β1-adrenergic receptors in the heart increases positive chronotropic and ionotropic action. Peripheral vascular resistance is increased by the widening of blood vessels, primarily in skeletal muscle, but also in renal and mesenteric blood circulation, which is caused by the β2-adrenergic system.
Uses
Isoproterenol is used in bronchospasms, asthma, cardiac block, and shock.
Definition
ChEBI: A secondary amino compound that is noradrenaline in which one of the hydrogens attached to the nitrogen is replaced by an isopropyl group. A sympathomimetic acting almost exclusively on beta-adrenergic receptors, it is used (mainly as the hy rochloride salt) as a bronghodilator and heart stimulant for the management of a variety of cardiac disorders.
Indications
Isoproterenol is administered almost exclusively by inhalation from metered-dose inhalers or from nebulizers. The response to inhaled isoproterenol and other inhaled adrenomimetics is instantaneous. The action of isoproterenol is short-lived, although an objective measurement of pulmonary function has shown an effective duration of up to 3 hours. When it is administered by inhalation, the cardiac effects of isoproterenol are relatively mild, although in some cases a substantial increase in heart rate occurs.
World Health Organization (WHO)
Isoprenaline, a beta-adrenoreceptor agonist, was introduced in 1949 as treatment for a number of cardiac disorders and as a bronchial dilator for the symptomatic treatment of asthma. There is evidence that regular inhalation of bronchodilator drugs is associated, in some cases with exacerbation of the disease and with increased fatality rates. The underlying causes are disputed, but an increasing body of opinion now advocates regular maintenance therapy with inhaled, corticosteroids coupled with supplementary use as required of bronchial drugs to suppress exacerbations.
General Description
Isoproterenol is a nonselective and prototypical -agonist ( β2/ β1=1). After oral administration,the absorption of ISO is rather erratic and undependable.The principal reason for its poor absorption characteristicsand relatively short DOA is its facile metabolism by sulfateand glucuronide conjugation of the phenolic OH groupsand O-methylation by COMT. Because it is a catechol, it issensitive to light and air. Aqueous solutions become pinkon standing. Unlike E and NE, ISO does not appear to undergo oxidative deamination by MAO. The drug hasDOA of 1 to 3 hours after inhalation.
Clinical Use
Isoproterenol is used principally by inhalation for the management of bronchospasm. It is also used intravenously for asthma and as a stimulant in cardiac arrest.
Safety Profile
Poison by ingestion, subcutaneous, intravenous, and intraperitoneal routes. An experimental teratogen. Other experimental reproductive effects. Human systemic effects by intramuscular route: increased pulse and cardac rate. A bronchodilator. Mutation data reported. When heated to decomposition it emits toxic fumes of NOx
Isoproterenol Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| Harman Finochem Ltd | +91-2226528080 +91-2226528080 | Maharashtra, India | 37 | 58 | Inquiry |
| Flowchem Pharma Pvt Ltd | +91-9606036218 +91-9845055636 | Karnataka, India | 33 | 58 | Inquiry |
| CLEARSYNTH LABS LTD. | +91-22-45045900 | Hyderabad, India | 6351 | 58 | Inquiry |
| Pharmaffiliates Analytics and Synthetics P. Ltd | +91-172-5066494 | Haryana, India | 6773 | 58 | Inquiry |
| Vcare Medicines | 08046035803 | Mumbai, India | 114 | 58 | Inquiry |
| Ligard Anesthesia | 09062331627 | Kolkata, India | 1 | 58 | Inquiry |
| Libertas | 08069033735Ext 211 | Gujarat, India | 29 | 58 | Inquiry |
| Pharma Affiliates | 172-5066494 | Haryana, India | 6761 | 58 | Inquiry |
| Capot Chemical Co.,Ltd. | 571-85586718 +8613336195806 | China | 29798 | 60 | Inquiry |
| Zhejiang ZETian Fine Chemicals Co. LTD | +8618957127338 | China | 2141 | 58 | Inquiry |
| Supplier | Advantage |
|---|---|
| Harman Finochem Ltd | 58 |
| Flowchem Pharma Pvt Ltd | 58 |
| CLEARSYNTH LABS LTD. | 58 |
| Pharmaffiliates Analytics and Synthetics P. Ltd | 58 |
| Vcare Medicines | 58 |
| Ligard Anesthesia | 58 |
| Libertas | 58 |
| Pharma Affiliates | 58 |
| Capot Chemical Co.,Ltd. | 60 |
| Zhejiang ZETian Fine Chemicals Co. LTD | 58 |
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