Cefditoren pivoxil
- CAS No.
- 117467-28-4
- Chemical Name:
- Cefditoren pivoxil
- Synonyms
- CEFDITOREN;Spectracef;CEFDITORIN PIVOXIL;Meiac;MEIACT;ME-1207;toubaotuolunzhi;toubaotuolkunzhi;ceditoren pivoxil;Cefditoren Pivoxi
- CBNumber:
- CB7377697
- Molecular Formula:
- C25H28N6O7S3
- Molecular Weight:
- 620.72
- MOL File:
- 117467-28-4.mol
- Modify Date:
- 2023/6/28 18:16:08
| Melting point | 207-209°C |
|---|---|
| alpha | D20 -48.5° (c = 0.5 in methanol) |
| Density | 1.55±0.1 g/cm3(Predicted) |
| storage temp. | Keep in dark place,Inert atmosphere,Store in freezer, under -20°C |
| solubility | DMSO (Slightly), Ethanol (Slightly), Methanol (Slightly, Heated) |
| form | Solid |
| pka | 8.08±0.60(Predicted) |
| color | Off-White to Pale Yellow |
| Merck | 14,1921 |
| CAS DataBase Reference | 117467-28-4(CAS DataBase Reference) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS08 |
|---|---|
| Signal word | Danger |
| Hazard statements | H317-H334 |
| Precautionary statements | P261-P285-P304+P341-P342+P311-P501-P261-P272-P280-P302+P352-P333+P313-P321-P363-P501 |
| RTECS | XI0367800 |
| HS Code | 2941.90.3000 |
Cefditoren pivoxil Chemical Properties,Uses,Production
Description
Cefditoren pivoxil is an orally active third generation cephalosporin introduced in Japan as a treatment for a broad range of bacterial infections including dermatological and other community acquired infections. Cefditoren pivoxil is reported to have a broad spectrum of activity against both Gram-positive and Gramnegative bacteria, more potent than many other existing agents of its class. In particular, it shows the highest therapeutic activity against S. pneumoniae and S. marcescens infections. It exhibits resistance to β-lactamase hydrolysis typical of third generation cephalosporins. As a prodrug of cefditoren, it is readily absorbed through GI tract and has low toxicity and side effects.
Chemical Properties
Off-White Powder
Uses
Cefditoren Pivoxil is an antibacterial and is a third generation cephalosporin.
Definition
ChEBI: The pivaloyloxymethyl ester prodrug of cefditoren.
Antimicrobial activity
It exhibits good activity against staphylococci, streptococci (but not enterococci), H. influenzae and M. catarrhalis, including β-lactamase-producing strains. Isolates of Str. pneumoniae exhibiting reduced susceptibility to penicillin are less susceptible (MIC 0.125–2 mg/L). Most enterobacteria, including many Enterobacter, Citrobacter, Serratia and Proteus spp., are susceptible. It is not active against Ps. aeruginosa, Sten. maltophilia or atypical respiratory pathogens such as Chlamydophila pneumoniae and M. pneumoniae. It is stable to staphylococcal and common enterobacterial β-lactamases.
Pharmacokinetics
Oral absorption: c. 70%
Cmax 200 mg oral: c. 1.8 mg/L after 1.5–3 h
Plasma half-life: 0.8–1.3 h
Volume of distribution: 9.3 L
Plasma protein binding: 88%
After oral administration the pivaloyl ester is rapidly cleaved
by esterases in the gut wall. Ingestion with food improves
the bioavailability. Plasma concentrations are raised in
elderly patients. There is no accumulation on repeated
dosing.
It is excreted unchanged in the urine with a half-life of
around 1.5 h, achieving a concentration of 150–200 mg/L
within 4 h. Dosage adjustment is recommended in patients
with deteriorating renal function.
Clinical Use
It has been advocated for community-acquired upper and lower respiratory tract infections and skin infections.
Side effects
In common with other pivoxil esters it may cause carnitine deficiency. Other side effects are those common to cephalosporins, mainly gastrointestinal disturbance.
Cefditoren pivoxil Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| Hetero Drugs Limited | +91-4023704923 +91-4023704923 | Telangana, India | 296 | 58 | Inquiry |
| Nectar Lifesciences Ltd | +91-9357244445 +91-9357244445 | Punjab, India | 29 | 58 | Inquiry |
| Ralington Pharma | +91-7948911722 +91-9687771722 | Gujarat, India | 1350 | 58 | Inquiry |
| Alfa Omega Pharma | +91-8050045945 +91-9972665399 | Maharashtra, India | 126 | 58 | Inquiry |
| Suvan LifeSciences (formerly Sansh Biotech Pvt Ltd) | +91-1142631798 +91-9899000024 | New Delhi, India | 55 | 58 | Inquiry |
| Covalent Laboratories Private Limited (Virchow Group) | +91-4049483333 +91-9866077161 | Telangana, India | 9 | 58 | Inquiry |
| Akums Lifesciences Ltd | +91-1147511000 +91-1147511000 | New Delhi, India | 38 | 58 | Inquiry |
| SETV ASRV LLP | +91-9731133411 +91-9731133411 | Telangana, India | 531 | 58 | Inquiry |
| Nectar Lifesciences Ltd. (NLL) | 91-172-3047713 | Punjab, India | 25 | 58 | Inquiry |
| OCEAN TRADING CORPORATION | +91(22) 24921669 | New Delhi, India | 6211 | 58 | Inquiry |
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