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PD 146176

PD 146176 Structure
CAS No.
4079-26-9
Chemical Name:
PD 146176
Synonyms
PD 146176;NSC168807;PD146176 (NSC168807);PD146176, 10 mM in DMSO;6,11-dihydrothiochromeno[4,3-b]indole;[1]Benzothiopyrano[4,3-b]indole, 6,11-dihydro-;inhibit,tau,brain,triple,NSC-168807,PD146176,Autophagy,pathology,amyloidosis,transgenic,reticulocyte,impairment,cognitive,mice,NSC 168807,Inhibitor,cells,PD 146176,IC21,PD-146176,rabbit,Ferroptosis
CBNumber:
CB7504219
Molecular Formula:
C15H11NS
Molecular Weight:
237.32
MOL File:
4079-26-9.mol
MSDS File:
SDS
Modify Date:
2025/1/27 9:38:02
Request For Quotation

PD 146176 Properties

Melting point 160 °C
Boiling point 485.4±24.0 °C(Predicted)
Density 1.333±0.06 g/cm3(Predicted)
storage temp. Store at +4°C
solubility DMSO: 16 mg/mL, soluble
form solid
pka 16.17±0.20(Predicted)
color cream-colored

SAFETY

Risk and Safety Statements

Symbol(GHS) 
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H335
Precautionary statements  P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P310-P330-P332+P313-P337+P313-P362-P403+P233-P405-P501
Safety Statements  22-24/25
WGK Germany  3

PD 146176 price More Price(2)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich(India) P4620 PD 146176 ≥98% (HPLC), solid 4079-26-9 5MG ₹17774.65 2022-06-14 Buy
Sigma-Aldrich(India) P4620 PD 146176 ≥98% (HPLC), solid 4079-26-9 25MG ₹71120.25 2022-06-14 Buy
Product number Packaging Price Buy
P4620 5MG ₹17774.65 Buy
P4620 25MG ₹71120.25 Buy

PD 146176 Chemical Properties,Uses,Production

Description

PD 146176 is a potent and selective inhibitor of reticulocyte 15-lipoxygenase-1. It limits hypercholesterolemia-induced atherosclerosis in New Zealand White rabbits and reduces oxidant stress-induced apoptosis in endothelial cells. PD 146176 inhibits amyloid β protein aggregate formation without changing total levels of amyloid β precursor protein (APP) in cells stably expressing APP. In addition, it lacks significant non-specific antioxidant properties.

Uses

PD 146176 has been used to study its influence on ex vivo leukotriene B4 (LTB4) and lipoxin A4 (LXA4) secretion in adipose tissue.

Biological Activity

Specific, non-competitve 15-lipoxygenase (15-LOX) inhibitor (K i = 197nM) that has no demonstrable effect on 5-LOX, 12-LOX, COX-1 or COX-2 (IC 50 = 0.54 μ M for 15-LOX in rabbit reticulocytes). Lacks non-specific antioxidant properties and prevents atherogenesis via regulation of monocyte-macrophage enrichment in vivo .

PD 146176 Preparation Products And Raw materials

Raw materials

Preparation Products

PD 146176 Suppliers

Global( 63)Suppliers
Supplier Tel Country ProdList Advantage Inquiry
Shaanxi Dideu Medichem Co. Ltd +86-29-81139210 +86-18192627656 China 3003 58 Inquiry
career henan chemical co +86-0371-86658258 +8613203830695 China 29808 58 Inquiry
ANHUI WITOP BIOTECH CO., LTD +8615255079626 China 23541 58 Inquiry
InvivoChem +1-708-310-1919 +1-13798911105 United States 6391 58 Inquiry
TargetMol Chemicals Inc. United States 38630 58 Inquiry
Aladdin Scientific United States 57505 58 Inquiry
Shanghai Aladdin Biochemical Technology Co.,Ltd. 400-6206333 1316706386 China 48458 58 Inquiry
InvivoChem 13549236410 China 6753 58 Inquiry
Olix (Shanghai) Pharmaceutical Technology Co., Ltd 17316404525 China 9976 58 Inquiry
Kaifeng Mingren Pharmaceutical Co.,LTD 0371-65741762 China 2380 58 Inquiry
Supplier Advantage
Shaanxi Dideu Medichem Co. Ltd 58
career henan chemical co 58
ANHUI WITOP BIOTECH CO., LTD 58
InvivoChem 58
TargetMol Chemicals Inc. 58
Aladdin Scientific 58
Shanghai Aladdin Biochemical Technology Co.,Ltd. 58
InvivoChem 58
Olix (Shanghai) Pharmaceutical Technology Co., Ltd 58
Kaifeng Mingren Pharmaceutical Co.,LTD 58

PD 146176 Spectrum

PD 146176(4079-26-9)1HNMR

4079-26-9(PD 146176)Related Search:

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15(S)-HEDE Esculetin REV 5901 Baicalein PD 146176
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6,11-dihydrothiochromeno[4,3-b]indole [1]Benzothiopyrano[4,3-b]indole, 6,11-dihydro- PD146176 (NSC168807) NSC168807 inhibit,tau,brain,triple,NSC-168807,PD146176,Autophagy,pathology,amyloidosis,transgenic,reticulocyte,impairment,cognitive,mice,NSC 168807,Inhibitor,cells,PD 146176,IC21,PD-146176,rabbit,Ferroptosis PD 146176 PD146176, 10 mM in DMSO 4079-26-9