PD 146176
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- ₹17774.65 - ₹71120.25
- Product name: PD 146176
- CAS: 4079-26-9
- MF: C15H11NS
- MW: 237.32
- EINECS:
- MDL Number:MFCD05664738
- Synonyms:6,11-dihydrothiochromeno[4,3-b]indole;[1]Benzothiopyrano[4,3-b]indole, 6,11-dihydro-;PD146176 (NSC168807);NSC168807;inhibit,tau,brain,triple,NSC-168807,PD146176,Autophagy,pathology,amyloidosis,transgenic,reticulocyte,impairment,cognitive,mice,NSC 168807,Inhibitor,cells,PD 146176,IC21,PD-146176,rabbit,Ferroptosis;PD 146176
2 prices
Selected condition：
Brand
- Sigma-Aldrich(India)
Package
- 5MG
- 25MG
- ManufacturerSigma-Aldrich(India)
- Product numberP4620
- Product descriptionPD 146176 ≥98% (HPLC), solid
- Packaging5MG
- Price₹17774.65
- Updated2022-06-14
- Buy
- ManufacturerSigma-Aldrich(India)
- Product numberP4620
- Product descriptionPD 146176 ≥98% (HPLC), solid
- Packaging25MG
- Price₹71120.25
- Updated2022-06-14
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | P4620 | PD 146176 ≥98% (HPLC), solid | 5MG | ₹17774.65 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | P4620 | PD 146176 ≥98% (HPLC), solid | 25MG | ₹71120.25 | 2022-06-14 | Buy |
Properties
Melting point :160 °C
Boiling point :485.4±24.0 °C(Predicted)
Density :1.333±0.06 g/cm3(Predicted)
storage temp. :Store at +4°C
solubility :DMSO: 16 mg/mL, soluble
form :solid
pka :16.17±0.20(Predicted)
color :cream-colored
Boiling point :485.4±24.0 °C(Predicted)
Density :1.333±0.06 g/cm3(Predicted)
storage temp. :Store at +4°C
solubility :DMSO: 16 mg/mL, soluble
form :solid
pka :16.17±0.20(Predicted)
color :cream-colored
Safety Information
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Description
PD-146176 is a potent and selective inhibitor of 15-LO that suppresses oxidant stress-induced apoptosis in endothelial cells. Studies indicate that PD-146176 reduces atherosclerotic lesion development in New Zealand white rabbit through its nonspecific antioxidant properties. It is known that PD-146176 acts as a noncompetitive inhibitor towards 15-LO, displaying a Ki=197 nM. Furthermore, PD-146176 reduces monocyte macrophage enrichment of atherosclerotic lesions and development of fibrofoamy and fibrous plaque.More related product prices
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![6,11-Dihydrothiochromeno[4,3-b]indole](https://img.chemicalbook.com/ProductImageEN/2019-12/small/b20434cc-b711-4793-a491-5566cea1c3c5.png){kind=small}