Ciclopirox
- CAS No.
- 29342-05-0
- Chemical Name:
- Ciclopirox
- Synonyms
- Penlac;6-Cyclohexyl-1-hydroxy-4-methylpyridin-2(1H)-one;gopmx;geprox;Loprox;HOE296b;Mycoster;Brumixol;Dafnegin;Cidochem
- CBNumber:
- CB7673863
- Molecular Formula:
- C12H17NO2
- Molecular Weight:
- 207.27
- MOL File:
- 29342-05-0.mol
- MSDS File:
- SDS
- Modify Date:
- 2024/3/16 15:42:00
| Melting point | 1440C |
|---|---|
| Boiling point | 350.0±25.0 °C(Predicted) |
| Density | 1.193±0.06 g/cm3(Predicted) |
| storage temp. | Keep in dark place,Sealed in dry,Room Temperature |
| solubility | Slightly soluble in water, freely soluble in anhydrous ethanol and in methylene chloride |
| form | Solid |
| pka | 6.25±0.58(Predicted) |
| color | Off-White |
| CAS DataBase Reference | 29342-05-0(CAS DataBase Reference) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302+H312+H332-H319 | |||||||||
| Precautionary statements | P261-P280-P301+P312-P302+P352+P312-P304+P340+P312-P305+P351+P338 | |||||||||
| RIDADR | UN 3077 9 / PGIII | |||||||||
| HS Code | 2933790002 | |||||||||
| NFPA 704 |
|
Ciclopirox price More Price(3)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | SML2011 | Ciclopirox ≥98% (HPLC) | 29342-05-0 | 50MG | ₹6679.03 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | SML2011 | Ciclopirox ≥98% (HPLC) | 29342-05-0 | 100MG | ₹12080.7 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | PHR1920 | Ciclopirox Pharmaceutical Secondary Standard; Certified Reference Material | 29342-05-0 | 500MG | ₹20621.63 | 2022-06-14 | Buy |
Ciclopirox Chemical Properties,Uses,Production
Chemical Properties
White or Light-Yellow Powder
Uses
Ciclopirox (Penlac) is a synthetic antifungal agent. Ciclopirox (Penlac) is used for topical dermatologic treatment of superficial mycoses. Ciclopirox (Penlac) is most useful against Tinea versicolor. [1] In a study conducted to further elucidate ciclopir
Definition
ChEBI: A cyclic hydroxamic acid that is 1-hydroxypyridin-2(1H)-one in which the hydrogens at positions 4 and 6 are substituted by methyl and cyclohexyl groups, repectively. A broad spectrum antigfungal agent, it also exhibits antibacterial acti ity against many Gram-positive and Gram-negative bacteria, and has anti-inflammatory properties. It is used a a topical treatment of fungal skin and nail infections.
Indications
Ciclopirox penetrates rapidly into and through the skin and nail keratin. After dermal application ofa1% cream formulation, about 1.3 % of the dose is absorbed. Serum levels range around 10 μg/L after application of a dose of 37 mg of ciclopirox. After vaginal administration, 15 – 20 % of the dose is absorbed. Ciclopirox penetrates well into the skin and nail matrix. Absorbed ciclopirox is mainly eliminated by the kidneys; 1.1 – 1.7 % of the topical dose is eliminated in the urine within four days. Only a fraction thereof is unaltered ciclopirox. Approximately 96% of the absorbed drug is bound to human serum proteins.
Antimicrobial activity
Ciclopirox has a broad in vitro antifungal activity spectrum, including dermatophytes, yeasts, and moulds. The most important fungi within the activity spectrum of ciclopirox. Ciclopirox is primarily fungistatic, but if the contact time is long enough and the concentration exceeds 20 μg/mL, it exerts a fungicidal effect on yeasts and dermatophytes. In vitro, the effect is limited to proliferating fungi and is greatly dependent on the nutrient medium.
Mechanism of action
Ciclopirox has a unique mechanism of action through chelation of polyvalent cations, such as Fe3+, which causes inhibition of a number of metal-dependent enzymes within the fungal cell.
Mechanism of action
Ciclopirox is a substituted pyridione derivative. Experiments show that the mechanism of action involves a disruption of transport mechanisms into the cell plasma, especially the uptake of leucine. Further, the uptake of other amino acids such as phenylalanine and lysine, as well as the uptake of potassium and phosphate ions is impaired. This all probably involves a change in membrane permeability, as reported for some other antimycotics, although ciclopirox does not show lytic activity. Consecutively, the substance significantly reduces fungal growth rates.
Clinical Use
Ciclopirox is a hydroxylated pyridinone that is employed for superficial dermatophytic infections, principally onychomycosis.
Side effects
Topically applied, ciclopirox is well tolerated. The incidence of local irritations such as itching and burning sensations range between 1 and 4 % and are often due to the galenic formulation.
Ciclopirox Preparation Products And Raw materials
Raw materials
1of2
chevron_rightPreparation Products
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| VIVAN Life Sciences Pvt Ltd | +91-2225870080 +91-9987465183 | Maharashtra, India | 49 | 58 | Inquiry |
| Precise Biopharma Pvt Ltd | +91-2267828600 +91-2267828600 | Maharashtra, India | 46 | 58 | Inquiry |
| Kumar Organic Products Ltd | +91-9845286706 +91-8041425832 | Karnataka, India | 26 | 58 | Inquiry |
| Kebee Pharmachemie Pvt., Ltd. | 91-22-28328669 | Maharashtra, India | 65 | 58 | Inquiry |
| Esschem Pvt., Ltd. | 91-22-22182485 | Maharashtra, India | 96 | 58 | Inquiry |
| Precise Biopharma Pvt., Ltd. | 91-22-67828600 | Maharashtra, India | 9 | 58 | Inquiry |
| Pharma Affiliates | 172-5066494 | Haryana, India | 6761 | 58 | Inquiry |
| Clearsynth Labs | 91-22-45045900 | Maharashtra, India | 3889 | 58 | Inquiry |
| A.J Chemicals | 91-9810153283 | New Delhi, India | 6124 | 58 | Inquiry |
| CLEARSYNTH LABS LTD. | +91-22-45045900 | Hyderabad, India | 6351 | 58 | Inquiry |
| Supplier | Advantage |
|---|---|
| VIVAN Life Sciences Pvt Ltd | 58 |
| Precise Biopharma Pvt Ltd | 58 |
| Kumar Organic Products Ltd | 58 |
| Kebee Pharmachemie Pvt., Ltd. | 58 |
| Esschem Pvt., Ltd. | 58 |
| Precise Biopharma Pvt., Ltd. | 58 |
| Pharma Affiliates | 58 |
| Clearsynth Labs | 58 |
| A.J Chemicals | 58 |
| CLEARSYNTH LABS LTD. | 58 |
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