L-METHIONINE SULFOXIMINE
- CAS No.
- 15985-39-4
- Chemical Name:
- L-METHIONINE SULFOXIMINE
- Synonyms
- L-METHIONINE-DL-SULFOXIMINE;L-Methionine [R,S]-Sulfoximine;MSX;L-Methionine Sulfoxime;L-Methionin-sulfoximine;L-METHIONINE SULFOXIMINE;L-Methionine sulfoxiimine;METHIONINE SULFOXIMINE (L);Methionine-rs-sulfoximine, L-;Methionine-DL-sulfoximine, DL-
- CBNumber:
- CB7690727
- Molecular Formula:
- C5H12N2O3S
- Molecular Weight:
- 180.23
- MOL File:
- 15985-39-4.mol
- MSDS File:
- SDS
- Modify Date:
- 2023/9/4 15:51:00
| Melting point | >210 °C (dec.)(lit.) |
|---|---|
| Boiling point | 352.2±52.0 °C(Predicted) |
| Density | 1.215 (estimate) |
| refractive index | 1.6430 (estimate) |
| storage temp. | 20-25°C |
| solubility | Aqueous Base (Slightly), Formic Acid (Slightly), Water (Sparingly, Sonicated) |
| form | Crystalline Powder |
| color | White or almost white |
| optical activity | [α]20/D +10.8 to +14.0°, c = 1 in H2O |
| BRN | 6175446 |
| Stability | Temperature Sensitive |
| CAS DataBase Reference | 15985-39-4(CAS DataBase Reference) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P264-P271-P280-P302+P352-P305+P351+P338 | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 26-36 | |||||||||
| WGK Germany | 3 | |||||||||
| HazardClass | IRRITANT | |||||||||
| HS Code | 29309090 | |||||||||
| NFPA 704 |
|
L-METHIONINE SULFOXIMINE price More Price(5)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | M5379 | L-Methionine sulfoximine | 15985-39-4 | 250MG | ₹10283.75 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | M5379 | L-Methionine sulfoximine | 15985-39-4 | 500MG | ₹16551.43 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | M5379 | L-Methionine sulfoximine | 15985-39-4 | 1G | ₹26304.75 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | M5379 | L-Methionine sulfoximine | 15985-39-4 | 5G | ₹103692.68 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 91016 | L-Methionine sulfoximine certified reference material, TraceCERT? | 15985-39-4 | 100MG | ₹31868.8 | 2022-06-14 | Buy |
L-METHIONINE SULFOXIMINE Chemical Properties,Uses,Production
Chemical Properties
White Crystalline Powder
Uses
L-Methionine sulfoximine has been used as a potent inhibitor of glutamine synthetase (GS) activity.
Biochem/physiol Actions
As a potent inhibitor of glutamine synthetase activity (GS), this reagent has widely been used as a selection agent for plasmid integration in Chinese hamster ovary (CHO) and other mammalian cell lines. The growing demand for high yield cell banks for production of recombinant proteins for therapeutics has resulted in two major systems for selection of stable and active clones, Methotrexate selection of dihydrofolate reductase (DHFR) overexpressing cells and MSX selection of glutamine synthetase overexpressing cells. Cells are grown in the absence of glutamine in the media and inhibition of the endogenous activity of glutamine synthetase results in cell death for cells lacking overexpression. The MSX-glutamine synthetase selection mechanism provides benefits over that of the Methotrexate-DHFR system in that it typically requires a single amplification step and results in significant reduction of time to produce high stability, highly amplified clones. L-Methionine sulfoximine (MSX) enhances NH3 production in seedling leaves wheat, barley, corn and sorghum plants by inhibiting GS activity. MSX increases ornithine decarboxylase activity and decreases the survival rate in a model of transient cerebral ischemia.
L-METHIONINE SULFOXIMINE Preparation Products And Raw materials
Raw materials
Preparation Products
L-METHIONINE SULFOXIMINE Suppliers
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| Innovassynth Technologies (I) Ltd. | +91-2192260100 +91-7208872197 | Maharashtra, India | 118 | 58 | Inquiry |
| Alfa Aesar | 1 800 209 7001 | Maharashtra, India | 6913 | 58 | Inquiry |
| Pharmaffiliates Analytics and Synthetics P. Ltd | +91-172-5066494 | Haryana, India | 6773 | 58 | Inquiry |
| Merck Life Science Private Limited | 08046045443 | Mumbai, India | 101 | 58 | Inquiry |
| A.J Chemicals | 91-9810153283 | New Delhi, India | 6124 | 58 | Inquiry |
| CLEARSYNTH LABS LTD. | +91-22-45045900 | Hyderabad, India | 6351 | 58 | Inquiry |
| Pharma Affiliates | 172-5066494 | Haryana, India | 6761 | 58 | Inquiry |
| Capot Chemical Co.,Ltd. | 571-85586718 +8613336195806 | China | 29798 | 60 | Inquiry |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | China | 21667 | 55 | Inquiry |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | China | 49392 | 58 | Inquiry |
15985-39-4(L-METHIONINE SULFOXIMINE)Related Search:
1of4
chevron_right