ChemicalBook > Product Catalog >API >Respiratory Drugs >Asthma drugs >Formoterol

Formoterol

CAS No.: 73573-87-2

Chemical Name:: Formoterol

Synonyms: FORMOTEROL TARTRATE;Oxis;FORMOTEROL;Formoteral;Eformoterol;FormoterolBase;1-nitrotridec-1-ene;Formoterol Standard;FORMOTEROL TARTARATE;Formoterol USP/EP/BP

CBNumber:: CB7722411

Molecular Formula:: C19H24N2O4

Molecular Weight:: 344.4

MOL File:: 73573-87-2.mol

Modify Date:: 2024/3/19 15:37:50

Request For Quotation

Formoterol Properties

Boiling point	603.2±55.0 °C(Predicted)
Density	1.233±0.06 g/cm3(Predicted)
solubility	DMSO: 20 mg/mL, soluble
form	solid
pka	8.95±0.50(Predicted)
color	off-white
Stability	Stable. Incompatible with strong oxidizing agents.
CAS DataBase Reference	73573-87-2(CAS DataBase Reference)

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS08
Signal word	Warning
Hazard statements	H362-H361
Precautionary statements	P201-P260-P263-P264-P270-P308+P313-P201-P202-P281-P308+P313-P405-P501
WGK Germany	3

Formoterol Chemical Properties,Uses,Production

Chemical Properties

solid

Uses

Labeled Formoterol, intended for use as an internal standard for the quantification of Formoterol by GC- or LC-mass spectrometry.

Definition

ChEBI: A phenylethanoloamine having 4-hydroxy and 3-formamido substituents on the phenyl ring and an N-(4-methoxyphenyl)propan-2-yl substituent.

General Description

Formoterol (Foradil) isalso a lipophilic (log P= 1.6) and long-acting β2-agonist. Ithas 3'-formylamino ( β-directing) and 4 OH groups on onephenyl ring and a lipophilic -directing N-isopropyl-pmethoxyphenylgroup on the nitrogen atom. Its long DOA(12 hours), which is comparable to that of salmeterol, hasbeen suggested to result from its association with the membranelipid bilayer, from which it gradually diffuses to provideprolonged stimulation of β2 receptors and its resistanceto MAO and COMT. Formoterol has a much faster onset ofaction than does salmeterol as result of its lower lipophilicity.Both of these long-acting drugs are used by inhalationand are recommended for maintenance treatment of asthma,usually in conjunction with an inhaled corticosteroid.

Mechanism of action

Formoterol has 3′-formylamino and 4′-hydroxy ring R3 substitution pattern but also an alkoxyphenylethyl lipophilic group R1 on the nitrogen, similar to ritodrine. Although it is less lipophilic (log P = 1.6) than salmeterol, it has a 12-hour duration of action similar to that for salmeterol. It is administered as an inhaled dry powder, because it is unstable to heat and moisture. It is a mixture of (R,R)-(–)- and (S,S)-(+)-stereoisomers, with the (R,R)-isomer having approximately 1,000-fold more affinity for the β2-receptor than the (S,S)-isomer. Because of its high potency and low dose, however, there is no clinical advantage for using (R,R)-formoterol as bronchodilator compared to the racemate. Unlike salmeterol, formoterol has a faster onset of action as a result of its lower lipophilicity. It is also more potent; a 12-μg dose of formoterol has been demonstrated to be equivalent to a 50-μg dose of salmeterol.

Formoterol Preparation Products And Raw materials

Raw materials

FORMOTEROL INTERMEDIATE Benzenemethanol, 3-amino-α-[[[(1R)-2-(4-methoxyphenyl)-1-methylethyl](phenylmethyl)amino]methyl]-4-(phenylmethoxy)-, (αR)- 2-Bromo-4'-Benzyloxy-3'-nitroacetophenone (R)-1-(4-Benzyloxy-3-nitrophenyl)-2-bromoethanol 1316100-17-0

1-(4-METHOXYPHENYL)-2-NITROPROPENE (R)-N-(2-(Benzyloxy)-5-(2-bromo-1-hydroxyethyl)phenyl)formamide Oxirane, [3-nitro-4-(phenylMethoxy)phenyl]-, (2R)- 4-Benzyloxy-3-nitroacetophenone Formoterol Impurity

N-(2-(benzyloxy)-5-((R)-1-hydroxy-2-(((R)-1-(4-Methoxyphenyl)propan-2-yl)aMino)ethyl)phenyl)forMaMide 2-(Benzylamino)-1-(4-methoxyphenyl)-propane (R)-(-)-1-(4'-methoxyphenyl)-2-benzylaminopropane 4-Methoxyphenylacetone

chevron_left

1of3

chevron_right

Preparation Products

Formoterol Suppliers

Global( 110)Suppliers

Supplier	Tel	Country	ProdList	Advantage	Inquiry
Pharmaffiliates Analytics and Synthetics P. Ltd	+91-172-5066494	Haryana, India	6773	58	Inquiry
SynZeal Research Pvt Ltd	+1 226-802-2078	Gujarat, India	6522	58	Inquiry
Taj Mahal Vision Chemicals Private Limited	07942557933	Mumbai, India	206	58	Inquiry
A.J Chemicals	91-9810153283	New Delhi, India	6124	58	Inquiry
CLEARSYNTH LABS LTD.	+91-22-45045900	Hyderabad, India	6351	58	Inquiry
Pharma Affiliates	172-5066494	Haryana, India	6761	58	Inquiry
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	China	21675	55	Inquiry
career henan chemical co	+86-0371-86658258 +8613203830695	China	29900	58	Inquiry
Xiamen AmoyChem Co., Ltd	+86-592-6051114 +8618959220845	China	6387	58	Inquiry
Chongqing Chemdad Co., Ltd	+86-023-6139-8061 +86-86-13650506873	China	39916	58	Inquiry

Supplier	Advantage
Pharmaffiliates Analytics and Synthetics P. Ltd	58
SynZeal Research Pvt Ltd	58
Taj Mahal Vision Chemicals Private Limited	58
A.J Chemicals	58
CLEARSYNTH LABS LTD.	58
Pharma Affiliates	58
Henan Tianfu Chemical Co.,Ltd.	55
career henan chemical co	58
Xiamen AmoyChem Co., Ltd	58
Chongqing Chemdad Co., Ltd	58

73573-87-2(Formoterol)Related Search:

Formoterol (R,R)-Formoterol tartrate (N,O-DIBENZYLATED) FORMOTEROL FUMARATE, 98% ( FOR FORMOTEROL FUMARATE ),N,O-DIBENZYLATED FORMOTEROL FUMARATE,n,o-dibenzylated formoterol Formoterol fumarate dihydrate Formoterol fumarate

Formoterol Intermediate Formamide FORMOTEROL FUMARATE HYDRATE FORMOTEROL-D6 (R,R)-Formoterol

Formoterol for impurity I identification FORMOTEROL FUMARATE FOR SYSTEM SUITABILITY (S,S)-Formoterol FORMOTEROL-D3 Formoterol·fumaric acid

( N, O Cdiphenzylated) Formoterol Fumarate (N,O-DIBENZYLATE) FORMOTEROL FUMANATE FORMOTEROL FUMARATE DIHYDRATE FOR IMPURITY I IDENTIFICATION

chevron_left

1of4

chevron_right

n-[2-hydroxy-5-[1-hydroxy-2-[1-(4-methoxyphenyl)propan-2-ylamino]ethyl]phenyl]formamide FORMOTEROL TARTARATE FormoterolBase Formoterol Fumarate 43229-80-7 / Base Eformoterol Formamide, N-[2-hydroxy-5-[(1R)-1-hydroxy-2-[[(1R)-2-(4-methoxyphenyl)-1-methylethyl]amino]ethyl]phenyl]-, rel- Formamide, N-[2-hydroxy-5-[1-hydroxy-2-[[2-(4-methoxyphenyl)-1-methylethyl]amino]ethyl]phenyl]-, (R*,R*)- Formamide, N-[2-hydroxy-5-[1-hydroxy-2-[[2-(4-methoxyphenyl)-1-methylethyl]amino]ethyl]phenyl]-, (R*,R*)-(+-)- Oxis N-[2-Hydroxy-5-[1(R)-hydroxy-2-[[2-(4-methoxyphenyl)-1(R)-methylethyl] amino]ethyl]phenyl]formamide FORMOTEROL rel-N-(2-Hydroxy-5-((R)-1-hydroxy-2-(((R)-1-(4-Methoxyphenyl)propan-2-yl)aMino)ethyl)phenyl)forMaMide N-(2-Hydroxy-5-((R)-1-hydroxy-2-(((R)-1-(4-methoxyphenyl)propan-2-yl)amino)ethyl)phenyl)formamide 1-nitrotridec-1-ene Formoterol USP/EP/BP Formoterol (10mM in DMSO) Formoteral FORMOTEROL TARTRATE Formoterol Standard 73573-87-2 C19H24N2O4 Other APIs Inhibitors (intermediates of formoterol ) API