Formoterol fumarate
- CAS No.
- 43229-80-7
- Chemical Name:
- Formoterol fumarate
- Synonyms
- Aformoterol;FORMOTEROL HEMIFUMARATE;YM 08316;FarMeterol;CGP 25827A;NSC 299587;CGP-25827A-e;Fumarate dihydrate;FORMAMIDE FUMARATE;FORADIL;FORMOTEROL
- CBNumber:
- CB5689602
- Molecular Formula:
- C42H52N4O12
- Molecular Weight:
- 804.88
- MOL File:
- 43229-80-7.mol
- Modify Date:
- 2024/7/2 8:55:11
| Melting point | 138-140°C |
|---|---|
| storage temp. | Room temperature |
| solubility | Slightly soluble in water, soluble in methanol, slightly soluble in 2-propanol, practically insoluble in acetonitrile. |
| pka | pKa1 7.9; pKa2 9.2(at 25℃) |
| form | Solid |
| color | White to off-white |
| λmax | 284nm(lit.) |
| Merck | 14,4245 |
| Stability | Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months. |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS06,GHS08 |
|---|---|
| Signal word | Danger |
| Hazard statements | H300-H361d-H370-H373-H412 |
| Precautionary statements | P201-P202-P260-P264-P273-P301+P310 |
| RIDADR | 3249 |
| RTECS | LQ2988000 |
| HazardClass | 6.1(b) |
| PackingGroup | II |
| Toxicity | LD50 in male, female, rats, mice (mg/kg): 3130, 5580, 6700, 8310 orally; 98, 100, 72, 71 i.v.; 1000, 1100, 640, 670 s.c.; 170, 210, 240, 210 i.p. (Yoshida) |
Formoterol fumarate Chemical Properties,Uses,Production
Description
Formoterol fumarate is a β2-selective adrenergic agonist useful in the treatment of bronchial asthma. It s potency and duration of action a r e reported to exceed those of salbutamol, as is its ability to inhibit allergic and non-allergic histamine release.
Chemical Properties
Crystalline Solid
Uses
Formoterol fumarate is a potent β2-AR agonist.
Mechanism of action
This is believed to result from formoterol's greater water solubility, allowing it to get to the receptor sites faster, whereas its moderate lipophilicity keeps it in the lungs longer. It is indicated for the long-term maintenance treatment of asthma and for patients with symptoms of nocturnal asthma who require regular treatment with inhaled, short-acting, β2-agonists. It is not indicated for patients whose asthma can be managed by occasional use of inhaled, short-acting, β2-agonists. Formoterol is available only as a powder in a capsule for administration via the aerosolizer. Patients should be cautioned not to take the capsules orally and to keep them in a safe place to avoid accidental oral administration.
Clinical Use
Formoterol has a β-directing N-isopropyl-p-methoxyphenyl group and a unique m-formamide and p-hydroxyphenyl ring, which provides selectivity for β2-receptors. It is resistant to MAO and COMT, making it a long-acting agonist. Formoterol has a more rapid onset as compared to salmeterol while maintaining the same long duration of action.
Formoterol fumarate Preparation Products And Raw materials
Raw materials
Preparation Products
Global( 372)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| SIMSON PHARMA LIMITED | +91-8291074273 | Shanghai, India | 228 | 58 | Inquiry |
| Navone Specialties (OPC) Pvt Ltd | +91-9323789882 +91-9323789882 | Maharashtra, India | 151 | 58 | Inquiry |
| Aarti Industries Limited (AIL) | +91-84596144931 +91-9920899935 | Maharashtra, India | 235 | 58 | Inquiry |
| MELODY HEALTHCARE PVT LTD | +undefined2228780912 | Maharashtra, India | 20 | 58 | Inquiry |
| Harman Finochem Ltd | +91-2226528080 +91-2226528080 | Maharashtra, India | 37 | 58 | Inquiry |
| Ralington Pharma | +91-7948911722 +91-9687771722 | Gujarat, India | 1350 | 58 | Inquiry |
| Progress Life Sciences Pvt Ltd | +91-2265101706 +91-2249781414 | Maharashtra, India | 38 | 58 | Inquiry |
| Gangwal Healthcare Pvt Ltd | +91-9320779960 | Maharashtra, India | 51 | 58 | Inquiry |
| GANGWAL CHEMICALS PVT LTD | +91 22 28889000 | New Delhi, India | 75 | 58 | Inquiry |
| Jayco Chemical Industries. | 91-22-28458881 | Maharashtra, India | 10 | 58 | Inquiry |
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formamide,n-(2-hydroxy-5-(1-hydroxy-2-((2-(4-methoxyphenyl)-1-methylethyl)amin
o)ethyl)phenyl)-,(e)-2-butenedioate(2:1)(salt),dihydrate
(+/-)-(R*,R*)-N-[2-HYDROXY-5-[1-HYDROXY-2-[[2-(4-METHOXYPHENYL)-1-METHYLETHYL]AMINO]ETHYL]PHENYL] FORMAMIDE HEMIFUMARATE
(R*,R*)-(+)-N-[2-HYDROXY-5-[1-HYDROXY-2-[[2-(4-METHOXYPHENYL)-1-METHYLETHYL]AMINO]ETHYL]-PHENYL]FORMAMIDE FUMARATE
(R*,R*)-N-[2-HYDROXY-5-[1-HYDROXY-2-[[2-(4-METHOXYPHENYL)-1-METHYLETHYL]AMINO]ETHYL]PHENYL]FORMAMIDE FUMARATE
Formoterol fumarate JP13
Formoterol fumarate 50 gram
FORMATEROL FUMATATE
FORMOTEROL FUMARATE, FOR SYSTEM SUITABILITY EP STANDARD
FORMOTEROL FUMARATE, FOR IMPURITY D IDENTIFICATION EP STANDARD
FORMOTEROL FUMARATE, EP STANDARD
rel-N-[2-Hydroxy-5-[(1R)-1-hydroxy-2-[[(1R)-2-(4-methoxyphenyl)-1-methylethyl]amino]ethyl]phenyl]formamide Fumarate Dihydrate
Formoterol & Formoterol Fumarate
FarMeterol
ForMaterol FuMarate
(R*,R*)-N-[2-HYDROXY-5-[1-HYDROXY-2-[[2
ForMoterol FuMarate EP/USP
ForMoterol FuMarate Dihydrate API
N-(2-hydroxy-5-((S)-1-hydroxy-2-((S)-1-(4-methoxyphenyl)propan-2-ylamino)ethyl)phenyl)formamide hemifumaric acid
Formoterol fumarate N-[2-Hydroxy-5-[[(1RS)-1-hydroxy-2-[[(1RS)-2-(4-methoxyphenyl)-1-methylethyl]amino]ethyl]phenyl]formamide (E)-2-butenedioate
Aformoterol
CGP 25827A
Eformoterol fumarate
Formamide, N-[2-hydroxy-5-[(1R)-1-hydroxy-2-[[(1R)-2-(4-methoxyphenyl)-1-methylethyl]amino]ethyl]phenyl]-, rel-, (2E)-2-butenedioate (2:1) (salt)
Formamide, N-[2-hydroxy-5-[1-hydroxy-2-[[2-(4-methoxyphenyl)-1-methylethyl]amino]ethyl]phenyl]-, (R*,R*)-(+-)-, (E)-2-butenedioate (2:1) (salt)
Formamide, N-[2-hydroxy-5-[1-hydroxy-2-[[2-(4-methoxyphenyl)-1-methylethyl]amino]ethyl]phenyl]-, (R*,R*)-, (E)-2-butenedioate (2:1) (salt)
NSC 299587
YM 08316
FORMOTEROL FUMARATE
FORMOTEROL HEMIFUMARATE
n-[2-hydroxy-5-[[(1rs)-1-hydroxy-2-[[(1rs)-2-(4-methoxyphenyl)-1-methylethyl]amino]ethyl]phenyl]formamide (e)-2-butenedioate
BD-40A, Atock, Foradil, Oxeze
Formoterol dihydrate fumarate
Formoterol monohydrate hemifumarate salt, (R*,R*)-N-[2-Hydroxy-5-[1-hydroxy-2-[[2-(4-methoxyphenyl)-1-methylethyl]amino]ethyl]phenyl]formamide fumarate
(R*,R*)-N-[2-Hydroxy-5-[1-hydroxy-2-[[2-(4-methoxyphenyl)-1-methylethyl]amino]ethyl]phenyl]formamide fumarate (2:1) salt
CGP-25827A-e
Fumarate dihydrate
FORMAMIDE FUMARATE
rel-N-(2-hydroxy-5-((R)-1-hydroxy-2-(((R)-1-(4-methoxyphenyl)propan-2-yl)amino)ethyl)phenyl)formamide hemifumarate
FORADIL;FORMOTEROL
N-[2-hydroxy-5-[(1R)-1-hydroxy-2-[[(1R)-(4-methoxyphenyl)-1-methylethyl]-amino]ethyl]phenyl]formamide
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Formoterol Fumarate Base
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43229-80-7
13229-80-7
2C19H24N2O4C4H4O4