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Mafenide acetate

Mafenide acetate  Structure
CAS No.
13009-99-9
Chemical Name:
Mafenide acetate
Synonyms
Mefamide;mafatate;MARFANIL;MAFENIDE;maphenideacetate;MAFENIDE ACETATE;Sulfamylon Acetate;Mafenidine Acetate;MAFENAMIDE ACETATE;Sulfamimeron acetate
CBNumber:
CB7750274
Molecular Formula:
C9H14N2O4S
Molecular Weight:
246.28
MOL File:
13009-99-9.mol
Modify Date:
2023/7/21 19:01:50

Mafenide acetate Properties

Melting point 151-152°C
storage temp. Inert atmosphere,2-8°C
solubility DMSO: soluble1mg/mL
form Solid
color white
CAS DataBase Reference 13009-99-9(CAS DataBase Reference)

SAFETY

Risk and Safety Statements

Symbol(GHS) 
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H332-H335
Precautionary statements  P261-P280-P305+P351+P338
WGK Germany  3
HazardClass  IRRITANT
HS Code  2935904000
Toxicity LD50 in rats, mice (mg/kg): 2040, 1580 i.v. (Skulan, Hoppe)

Mafenide acetate Chemical Properties,Uses,Production

Chemical Properties

Crystalline Solid

General Description

4-(Aminomethyl)benzenesulfonamide acetate (Sulfamylon)is a homologue of the sulfanilamide molecule. It is not atrue sulfanilamide-type compound, as it is not inhibited byPABA. Its antibacterial action involves a mechanism thatdiffers from that of true sulfanilamide-type compounds.
This compound is particularly effective against Clostridiumwelchii in topical application and was used duringWorld War II by the German army for prophylaxis ofwounds. It is not effective orally. It is currently used aloneor with antibiotics in the treatment of slow-healing, infectedwounds.
Some patients treated for burns with large quantities ofthis drug have developed metabolic acidosis. To overcomethis adverse effect, a series of new organic salts was prepared. The acetate in an ointment base proved to be themost efficacious.

Mafenide acetate Preparation Products And Raw materials

Raw materials

Preparation Products

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Mafenide acetate Spectrum

4-aminomethylbenzenesulfonamide acetate salt 4-(aminomethyl)benzenesulfonamidemonoacetate 4-(aminomethyl)benzenesulfonimideacetate Mafenide Acetate (400 mg) Methotroxate Disodium α-AMINO-P-TOLUENSULFONAMIDEMONOACETATE A-AMINO-P-TOLUENSULFONAMIDEMONOACETATE Mefamide Sulfamylon Acetate α-Amino-p-toluenesulfonamide Acetate a-Amino-p-toluenesulfonamide Acetate Mafenide Acetate (200 mg) Mafenide acetate, >=99% 4-HOMOSULFANILAMIDE ACETATE 4-HOMOSULFANILAMIDE ACETATE SALT 4-(AMINOMETHYL)-BENZENESULFOAMIDE MONOACETATE 4-(AMINOMETHYL)BENZENESULFONAMIDE ACETATE ALPHA-AMINO-P-TOLUENSULFONAMIDE MONOACETATE P-(AMINOMETHYL) BENZENESULFONAMIDE ACETATE P-AMINOMETHYLBENZENESULFONAMIDE ACETATE SALT alpha-aminotoluene-4-sulphonamide monoacetate Mafenidine Acetate MAFENIDE ACETATE, 4-(AMINOMETHYL)-BENZENESULFOAMIDE MONOACETATE 4-(aminomethyl)-benzenesulfonamidmonoacetate alpha-amino-p-toluenesulfonamidmonoacetate mafatate maphenideacetate MARFANIL MARFANIL ACETATE SALT MAFENAMIDE ACETATE MAFENIDE MAFENIDE ACETATE MAFENIDE ACETATE SALT Benzenesulfonamide, 4-(aminomethyl)-, acetate (1:1) Mafenide acetate USP/EP/BP Mafenide Acetate (1373008) Sulfamimeron acetate 13009-99-9 C7H10N2O2SC2H4O2 C2H4O2C7H10N2O2S Analytical Standards AM to AQ Analytical Chromatography Product Catalog Alphabetic Intermediates & Fine Chemicals Pharmaceuticals Sulfur & Selenium Compounds APIs bc0001