Irsogladine maleate
- CAS No.
- 84504-69-8
- Chemical Name:
- Irsogladine maleate
- Synonyms
- Irgas;gaslon;mn-1695;Inomarl;Gasroil;Gaslon N;Irsogladin maleate;Irsogladine maleate;Maleate irsogladine;IrsogladineMaleate>
- CBNumber:
- CB8105343
- Molecular Formula:
- C13H11Cl2N5O4
- Molecular Weight:
- 372.16
- MOL File:
- 84504-69-8.mol
- MSDS File:
- SDS
- Modify Date:
- 2024/3/16 7:03:48
| Melting point | 181-182°C |
|---|---|
| storage temp. | Inert atmosphere,Room Temperature |
| Water Solubility | Insoluble in water |
| solubility |
DMF:30.0(Max Conc. mg/mL);80.61(Max Conc. mM) DMSO:30.0(Max Conc. mg/mL);80.61(Max Conc. mM) DMSO:PBS (pH 7.2) (1:3):0.25(Max Conc. mg/mL);0.67(Max Conc. mM) |
| form | White crystalline powder. |
| color | White to Almost white |
| Merck | 14,5102 |
| CAS DataBase Reference | 84504-69-8(CAS DataBase Reference) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS08 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H361 | |||||||||
| Precautionary statements | P201-P202-P281-P308+P313-P405-P501 | |||||||||
| RTECS | XY5930000 | |||||||||
| HS Code | 2933.69.6050 | |||||||||
| Toxicity | LD50 in male, female mice, rats (mg/kg): 6035, 5697, 3898, 2917 orally; 2841, 3216, 1600, 1524 s.c.; 775, 1006, 558, 545 i.p. (Ueda, 1984 p 474) | |||||||||
| NFPA 704 |
|
Irsogladine maleate price More Price(2)
Irsogladine maleate Chemical Properties,Uses,Production
Description
Irsogladine is a gastroprotective agent. It increases transfer of Lucifer yellow CH between isolated rabbit gastric epithelial cells, indicating enhanced gap junction intercellular communication (GJIC). Irsogladine (3 mg/kg) inhibits gastric mucosal lesion formation and decreases in gastric mucosal blood flow induced by monochloramine in rats, effects that can be prevented by the nitric oxide synthase inhibitor L-NAME . It also inhibits superoxide anion production induced by fMLP and increases cAMP levels in isolated human neutrophils in a concentration-dependent manner, similar to the phosphodiesterase 4 (PDE4) inhibitor rolipram .
Chemical Properties
White Solid
Biological Activity
Phosphodiesterase 4 (PDE4) inhibitor that displays gastroprotective properties. Prevents gastric mucosal injury induced by monochloramine and ischemia-reperfusion. Activates gap-junctional intercellular communication improving gastric mucosal barrier function. Inhibits superoxide production in human neutrophils and inhibits in vitro and in vivo angiogenesis.
Irsogladine maleate Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| Hetero Drugs Limited | +91-4023704923 +91-4023704923 | Telangana, India | 296 | 58 | Inquiry |
| Sai Prathyu Marketing | 91-9666672409 | Hyderabad, India | 162 | 58 | Inquiry |
| Hetero Drugs Limited | 08048372500Ext 439 | Hyderabad, India | 174 | 58 | Inquiry |
| A.J Chemicals | 91-9810153283 | New Delhi, India | 6124 | 58 | Inquiry |
| CLEARSYNTH LABS LTD. | +91-22-45045900 | Hyderabad, India | 6351 | 58 | Inquiry |
| TCI Chemicals (India) Pvt. Ltd. | 1800 425 7889 | New Delhi, India | 6778 | 58 | Inquiry |
| Hebei Mojin Biotechnology Co., Ltd | +8613288715578 | China | 12456 | 58 | Inquiry |
| Sigma Audley | +86-18336680971 +86-18126314766 | China | 491 | 58 | Inquiry |
| career henan chemical co | +86-0371-86658258 +8613203830695 | China | 29898 | 58 | Inquiry |
| Xiamen AmoyChem Co., Ltd | +86-592-6051114 +8618959220845 | China | 6387 | 58 | Inquiry |
| Supplier | Advantage |
|---|---|
| Hetero Drugs Limited | 58 |
| Sai Prathyu Marketing | 58 |
| Hetero Drugs Limited | 58 |
| A.J Chemicals | 58 |
| CLEARSYNTH LABS LTD. | 58 |
| TCI Chemicals (India) Pvt. Ltd. | 58 |
| Hebei Mojin Biotechnology Co., Ltd | 58 |
| Sigma Audley | 58 |
| career henan chemical co | 58 |
| Xiamen AmoyChem Co., Ltd | 58 |