2-HYDROXY-3''-NITRO-BIPHENYL-3-CARBOXYLIC ACID

2-HYDROXY-3''-NITRO-BIPHENYL-3-CARBOXYLIC ACID Structure
CAS No.
376591-95-6
Chemical Name:
2-HYDROXY-3''-NITRO-BIPHENYL-3-CARBOXYLIC ACID
Synonyms
Eltrombopag o;4,5,9,16-Pyrenetetrone;Nalbuphine Impurity 11;Eltrombopag Impurity 21;Eltrombopag Impurity 44;Eltrombopag Impurity 13;Eltrombopag olamine Intermediate 2;3-(2-hydroxy-3-nitrophenyl)benzoicaci;3-(2-hydroxy-3-nitrophenyl)benzoic acid;2'-hydroxy-3'-nitro-3-biphenylcarboxylic acid
CBNumber:
CB81501917
Molecular Formula:
C13H9NO5
Molecular Weight:
259.21
MOL File:
376591-95-6.mol
Modify Date:
2024/4/16 19:45:28

2-HYDROXY-3''-NITRO-BIPHENYL-3-CARBOXYLIC ACID Properties

Boiling point 452.2±40.0 °C(Predicted)
Density 1.460±0.06 g/cm3(Predicted)
storage temp. Room Temperature
solubility Tetrahydrofuran; Methanol;
form Solid
pka 3.96±0.10(Predicted)
color Yellow

SAFETY

Risk and Safety Statements

Symbol(GHS) 
GHS07
Signal word  Warning
Hazard statements  H315-H319
Precautionary statements  P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313

2-HYDROXY-3''-NITRO-BIPHENYL-3-CARBOXYLIC ACID Chemical Properties,Uses,Production

Uses

3’-Nitro-2’-hydroxy[1,1’]-biphenyl-3-carboxylic Acid is an intermediate used in the synthesis of N-Hydroxy Eltrombopag (H825795), which is a derivative compound of Eltrombopag (508000), an agonist of the Thrombopoietin (Tpo) receptor, used as treatment for thrombocytopenia.

2-HYDROXY-3''-NITRO-BIPHENYL-3-CARBOXYLIC ACID Preparation Products And Raw materials

Raw materials

Preparation Products

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2'-hydroxy-3'-nitro-3-biphenylcarboxylic acid 2'-Hydroxy-3'-nitro-[1,1'-biphenyl]-3-carboxylic acid 2-HYDROXY-3''-NITRO-BIPHENYL-3-CARBOXYLIC ACID 3-(2-hydroxy-3-nitrophenyl)benzoic acid Eltrombopag o Eltrombopag olamine Intermediate 2 3’-Nitro-2’-hydroxy[1,1’]-biphenyl-3-carboxylic Acid [1,1'-Biphenyl]-3-carboxylic acid, 2'-hydroxy-3'-nitro- Eltrombopag Impurity 13 Eltrombopag Impurity 44 Eltrombopag Impurity 21 4,5,9,16-Pyrenetetrone 3-(2-hydroxy-3-nitrophenyl)benzoicaci 2'- hydroxy -3'- nitrobiphenyl -3- carboxylic acid 2'-hydroxy-3'-nitro-3- biphenylcarboxylic acid Nalbuphine Impurity 11 376591-95-6