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N-[4-Cyano-3-(trifluoromethyl)phenyl]-3-[(4-fluorophenyl)thio]-2-hydroxy-2-methylpropionamide

N-[4-Cyano-3-(trifluoromethyl)phenyl]-3-[(4-fluorophenyl)thio]-2-hydroxy-2-methylpropionamide Structure
CAS No.
90356-78-8
Chemical Name:
N-[4-Cyano-3-(trifluoromethyl)phenyl]-3-[(4-fluorophenyl)thio]-2-hydroxy-2-methylpropionamide
Synonyms
BicalutaMide Sulfide;Bicalutamide-EP-Imp-J;Bicalutamide Intermediate;Bicalutamide EP Impurity J;INTERMEDIATE OF BICALUTAMIDE;N-[4-Cyano-3-(trifluoromethyl);Bicalutamide Impurity 8(EP Impurity J);Bicalutamide intermediate (thio ether);BICALUTAMIDE-SULFIDE (BICALUTAMIDE ASH);Bicalutamide EP Impurity J (Bicalutamide Sulfide)
CBNumber:
CB8250746
Molecular Formula:
C18H14F4N2O2S
Molecular Weight:
398.37
MOL File:
90356-78-8.mol
Modify Date:
2023/5/4 15:15:48

N-[4-Cyano-3-(trifluoromethyl)phenyl]-3-[(4-fluorophenyl)thio]-2-hydroxy-2-methylpropionamide Properties

Melting point 109-111°C
Boiling point 565.6±50.0 °C(Predicted)
Density 1.43±0.1 g/cm3(Predicted)
storage temp. Sealed in dry,Room Temperature
solubility Chloroform (Slightly), Methanol (Slightly)
form Solid
pka 12.31±0.29(Predicted)
color White
PH 6.45 at 24℃ and 10g/L
LogP 3.8 at 30℃
CAS DataBase Reference 90356-78-8(CAS DataBase Reference)

SAFETY

Risk and Safety Statements

Symbol(GHS) 
GHS07,GHS09
Signal word  Warning
Hazard statements  H317-H411
Precautionary statements  P261-P272-P280-P302+P352-P333+P313-P321-P363-P501
Safety Statements  24/25
HS Code  29242990

N-[4-Cyano-3-(trifluoromethyl)phenyl]-3-[(4-fluorophenyl)thio]-2-hydroxy-2-methylpropionamide Chemical Properties,Uses,Production

Chemical Properties

White Solid

Uses

Bicalutamide intermediate.

N-[4-Cyano-3-(trifluoromethyl)phenyl]-3-[(4-fluorophenyl)thio]-2-hydroxy-2-methylpropionamide Preparation Products And Raw materials

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(R,S)-N-[4-Cyano-3-(trifluoroMethyl)phenyl]-3-[(4-fluorophenyl)thio]-2-hydroxy-2-MethylpropionaMide N-[4-Cyano-3-(TrifluoroMethyl)Phenyl]-3-[(4-Fluorophenyl)thio]-2-Hydroxy-2-Methy-PropanaMide N-[4-Cyano-3-trifluoroMethy phenyl]-S-(4-fluorophenylthio)-2-hydrdoxy-2-Methyl-propionaMide(ASH BicalutaMide) N-[4-cyano-3-(rifluoromethyl)phenyl]-3-[(4-fluorophenyl)thio]-2- hydroxy-2-methyl propan Amide Bicalutamide EP Impurity J N-[4-Cyano-3-(trifluoromethyl)phenyl]-3-[(4-fluorophenyl)thio]-2-hydroxy-2-methylpropiomide 4-CYANO-3-TRIFLUOROMETHYL-N-[3-(4-FLUOROPHENYLTHIO)-2-HYDROXYL-2-METHYLPROPIONYL]ANILINE (S)-N-[4-CYANO-3-(TRIFLUOROMETHYL)PHENYL]-3-(4-FLUOROPHENYLTHIO)-2-HYDROXY-2-METHYLPROPANAMIDE N-[4-CYANO-3-(TRIFLUOROMETHYL)PHENYL]-3-[(4-FLUOROPHENYL)THIO]-2-HYDROXY-2-METHYL PROPANAMIDE N-[4-CYANO-3-(TRIFLUOROMETHYL)PHENYL]-3-[(4-FLUOROPHENYL)THIO]-2-HYDROXY-2-METHYLPROPIONAMIDE Bicalutamide Intermediate BICALUTAMIDE-SULFIDE (BICALUTAMIDE ASH) N-[4-Cyano-3-(Trifluoromethyl)Phenyl]-3-[(4-Fluorophenyl)thio]-2-Hydroxy-2-Methy N-[4-CYANO-3-(TRIFLUOROMETHYL)PHENYL]-3-[(4-FLUOROPHENYL)THIO] -2- HYDROXY-2-MET 4-OYANO-3-TRIFLUOROMETHYL-N-[3-(4-FLUOROPHENYLTHIO)-2-HYDROXYL-2-METHYLPROPIONYL]ANILINE H-(4-CYANO-3-TRIFLUOROMTHYLPHENYL)-3-(4-FLOUROPHENYLSULFANYL)-2-HYDROXY-2-METHYLPROPIONAMIDE N-[4-Cyano-3-(trifluoromethyl) 4-cyano-3-trifluoromethyl-N-[3-(4-fluorophenylthio)-2-hydroxyl-2-methylpropionyl]aniline (intermediate of bicalutamide) INTERMEDIATE OF BICALUTAMIDE 4-Cyano-3-(trifluoromethyl)phenyl-3-(4-fluorophenyl)thio)-2-methylpropanamide BicalutaMide Sulfide (2S)-N-[4-cyano-3-(trifluoroMethyl)phenyl]-3-[(4-fluorophenyl)sulfanyl]-2-hydroxy-2-MethylpropanaMide N-[4-cyano-3-(rifluoromethyl)phenyl]-3-[(4-fluorophenyl)thio]-2- N-[4-Cyano-3-trifluoromethy phenyl]-S-(4-fluorophenylthio)-2-hydrdoxy-2-methyl-propionamide Bicalutamide Impurity 8(EP Impurity J) Bicalutamide-EP-Imp-J N-[4-Cyano-3-(Trifluoromethyl)Phenyl]-3-[(4-Fluorophenyl)Thio]-2-Hydroxy-2-Methylpropionamid Bicalutamide EP Impurity J (Bicalutamide Sulfide) N-[4-Cyano-3-(Trifluoromethyl)phenyl]-3-[(4-Fluorophenyl)thio]-2-Hydroxy-2-Methyl Propanamide, N-[4-cyano-3-(trifluoromethyl)phenyl]-3-[(4-fluorophenyl)thio]-2-hydroxy-2-methyl- Bicalutamide Impurity 8(Bicalutamide EP Impurity J) N-[4-cyano-3-tri?uoromethylphenyl]-3-[4-?uorophenylthio]-2- hydroxy-2methylpropionamide N-[4-Cyano-3-(Trifluoromethyl)phenyl]-3-[(4-Fluorophenyl)thi... 3-(4-fluorophenylthio)-N-(4-Cyano-3-(trifluoromethyl) phenyl)-2-hydroxy-2-methylpropanamideQ: What is 3-(4-fluorophenylthio)-N-(4-Cyano-3-(trifluoromethyl) phenyl)-2-hydroxy-2-methylpropanamide Q: What is the CAS Number of 3-(4-fluorophenylthio)-N-(4-Cyano-3-(trifluoromethyl) phenyl)-2-hydroxy-2-methylpropanamide Q: What is the storage condition of 3-(4-fluorophenylthio)-N-(4-Cyano-3-(trifluoromethyl) phenyl)-2-hydroxy-2-methylpropanamide Q: What are the applications of 3-(4-fluorophenylthio)-N-(4-Cyano-3-(trifluoromethyl) phenyl)-2-hydroxy-2-methylpropanamide Bicalutamide intermediate (thio ether) N-[4-Cyano-3-(trifluoromethyl)phenyl]-3-[(4-fluorophenyl)thio]-2-hydroxy-2-methylpropionamide N - [4-Cyano-3- (trifluoromethyl) phenyl] -3- (4-fluorophenylthiol) -2-hydroxy-2-methylpropanamide 4-Cyano-3-trifluoromethyl-N-[3-(4-fluorophenyl)thio-2-hydroxy-2-methylpropionyl]aniline Bicalutamide intermediate (thio ether) N-[4-Cyano-3- (trifluoromethyl)phenyl]-3- [(4-fluorophenyl)thio]-2- 90356-78-8 90326-78-8 C18H14F4N2O2S Aromatics Intermediates & Fine Chemicals Pharmaceuticals Bicalutamide (intermediate of bicalutamide)