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ChemicalBook > Product Catalog >Biochemical Engineering >nucleic acid drugs >2'-O-(2-Methoxyethyl)-5-methyluridine

2'-O-(2-Methoxyethyl)-5-methyluridine

2'-O-(2-Methoxyethyl)-5-methyluridine Structure
CAS No.
163759-49-7
Chemical Name:
2'-O-(2-Methoxyethyl)-5-methyluridine
Synonyms
MOE-mrU;2'-O-MOE-Tr;2'-O-MOE-Tr;2'-MOE-5-Me-rU;5-Me-2'-O-MOE U;5-Me-2'-O-MOE U;5-Me-2'-O-MOE-Ur;2'-O-MOE-5-Me-rU;5-Me-2'-O-MOE-Me-U;2'-MOE-5-Me-Uridine
CBNumber:
CB82510024
Molecular Formula:
C13H20N2O7
Molecular Weight:
316.31
MOL File:
163759-49-7.mol
MSDS File:
SDS
Modify Date:
2023/11/28 11:20:42
Request For Quotation

2'-O-(2-Methoxyethyl)-5-methyluridine Properties

Melting point 115.5-116.5 °C
Density 1.41
storage temp. 2-8°C
solubility DMSO (Slightly), Methanol (Slightly), Water (Slightly, Sonicated)
form Solid
pka 9.55±0.10(Predicted)
color Off-White
Stability Hygroscopic
InChI InChI=1S/C13H20N2O7/c1-7-5-15(13(19)14-11(7)18)12-10(21-4-3-20-2)9(17)8(6-16)22-12/h5,8-10,12,16-17H,3-4,6H2,1-2H3,(H,14,18,19)/t8-,9-,10-,12-/m1/s1
InChIKey NEVQCHBUJFYGQO-DNRKLUKYSA-N
SMILES OC[C@H]1O[C@@H](N2C=C(C)C(=O)NC2=O)[C@H](OCCOC)[C@@H]1O

SAFETY

Risk and Safety Statements

Symbol(GHS) 
GHS07
Signal word  Warning
Hazard statements  H302-H315-H320-H335
Precautionary statements  P261-P280-P301+P312-P302+P352-P305+P351+P338

2'-O-(2-Methoxyethyl)-5-methyluridine Chemical Properties,Uses,Production

Uses

2'-O-(2-Methoxyethyl)-5-methyluridine is a protected uridine derivative (U829910) and nucleoside used in the preparation of synthetic nucleic acids.

Application

2'-O-(2-Methoxyethyl)-5-methyluridine (2'-MOE-5-Methyluridine) is a uridine nucleoside that is a combination of amidite with 5-methyluridine. 2'-MOE-5-Methyluridine is an intermediate in the synthesis of oligonucleotides, which are synthesized from phosphoramidites. Its analog 5'-O-DMT-2'-O-(2-methoxyethyl)-5-methyluridine is a potent compound used in research of RNA viruses, particularly hepatitis C virus and picornaviruses.

Synthesis

1.jpg
2,2'-Anhydro-5-methyluridine (195 g, 0.81 M), tris(2-methoxyethyl)borate (231 g, 0.98 M) and 2-methoxyethanol (1.2 L) were added to a 2 L stainless steel pressure vessel and placed in a pre-heated oil bath at 160°C. After heating for 48 hours at 155-160°C, the vessel was opened and the solution evaporated to dryness and triturated with methanol (200 mL). The residue was suspended in hot acetone (1 L). The insoluble salts were filtered, washed with acetone (150 mL) and the filtrate evaporated. The residue (280 g) was dissolved in CH3CN (600 mL) and evaporated. A silica gel column (3 kg) was packed in CH2Cl2/ acetone/methanol (20:5:3) containing 0.5% Et3NH. The residue was dissolved in CH2Cl2 (250 mL) and adsorbed onto silica (150 g) prior to loading onto the column. The product was eluted with the packing solvent to give product. Yield 160 g, 63%.

2'-O-(2-Methoxyethyl)-5-methyluridine Preparation Products And Raw materials

Raw materials

tris(2-methoxyethyl) orthoborate 2,2'-Anhydro-5-methyluridine 2-Methoxyethanol

Preparation Products

2'-O-(2-Methoxyethyl)-5-methyluridine Suppliers

Global( 114)Suppliers
Supplier Tel Country ProdList Advantage Inquiry
Vardhaman P Golechha 9704422000 Telangana, India 294 58 Inquiry
Gagri Global IT Services Pvt. Ltd. +91-40-27170174, Telangana, India 1321 58 Inquiry
Yunbio Tech Co.,Ltd. +86-010-60605551 +86-18046518538 China 321 58 Inquiry
career henan chemical co +86-0371-86658258 +8613203830695 China 29888 58 Inquiry
Shenzhen Nexconn Pharmatechs Ltd +86-755-89396905 +86-15013857715 China 10311 58 Inquiry
Jinan Carbotang Biotech Co.,Ltd. +8615866703830 China 7621 58 Inquiry
Chongqing Chemdad Co., Ltd +86-023-6139-8061 +86-86-13650506873 China 39916 58 Inquiry
SHANGHAI T&W PHARMACEUTICAL CO., LTD. +86-021-61551413 +8618813727289 China 5738 58 Inquiry
SIMAGCHEM CORP +86-13806087780 China 17367 58 Inquiry
Finetech Industry Limited +86-27-87465837 +8618971612321 China 9640 58 Inquiry
Supplier Advantage
Vardhaman P Golechha 58
Gagri Global IT Services Pvt. Ltd. 58
Yunbio Tech Co.,Ltd. 58
career henan chemical co 58
Shenzhen Nexconn Pharmatechs Ltd 58
Jinan Carbotang Biotech Co.,Ltd. 58
Chongqing Chemdad Co., Ltd 58
SHANGHAI T&W PHARMACEUTICAL CO., LTD. 58
SIMAGCHEM CORP 58
Finetech Industry Limited 58

163759-49-7(2'-O-(2-Methoxyethyl)-5-methyluridine)Related Search:

2'-O-Methylcytidine DMT-2μ-O-Me-rG(ib) amidite 2’-O-Methyl-rA(N-Bz)phosphoramidite DMT-2′Fluoro-dU Phosphoramidite 2'-O-MOE-A(Bz)-3'-phosphoramidite
N-blocked-5'-O-DMT-2'-O-Me CED cytosine phosphoramidite N4-Benzoyl-5'-O-DMT-2'-O-methyl-5-methylcytidine 3'-CE phosphoramidite Dmt-2'-f-dc(ac) amidite 2'-O-Methyladenosine 2'-O-(2-Methoxyethyl)cytidine
2'-O-Methylguanosine 2'-O-(2-Methoxyethyl)uridine DMT-2'-O-MOE-rU Phosphoramidite 2'-O-MOE-ADENOSINE 2'-OMe-ibu-G Phosphoramidite
2'-O-(2-Methoxyethyl)guanosine
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2'-O-(2-Methoxyethyl)-5-methyluridine 5-Me-2'-O-MOE U Uridine, 2'-O-(2-Methoxyethyl)-5-Methyl- 5-Me-2'-O-MOE Uridine 2'-O-(2-Methoxyethy)-5-methyluridine 2'-O-(2-Methoxyethyl)-5-Methyl-uridine, >97% 1-[4-HYDROXY-5-(HYDROXYMETHYL)-3-(2-METHOXYETHOXY)OXOLAN-2-YL]-5-METHYL-3H-PYRIMIDINE-2,4-DIONE 2'-O-MOE-5-Methyluridin 2'-O-MOE-Tr 2'-O-Methoxyethyl-thyminde 1-[(2R,3R,4R,5R)-4-hydroxy-5-(hydroxymethyl)-3-(2-methoxyethoxy)oxolan-2-yl]-5-methylpyrimidine-2,4-dione 2'-MOE-5-Me-Uridine 2’-MOE-5-Methyluridine 5-Me-2'-O-MOE-Ur MOE-mrU 2'-MOE-5-Me-rU 2'-O-Methoxyethyl-5-methyluridine 2'-O-MOE-5-Me-rU 2'-O-(2-Methoxyethyl)-5-methyluridine 2’-O-(2-Methoxyethy)-5-methyl uridine 5-Me-2'-O-MOE U 2'-MOE-5-Methyluridine 2'-O-Methoxyethyl-thymine 5-Me-2'-O-MOE-Me-U 2'-O-MOE-Tr 2'-o-Methoxyethyl-5-methyluridine 163759-49-7 Modified（deoxy）nucleoside Nucleosides-2'-O-MOE Nucleosides