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Methyl 1-acetyl-2-oxoindoline-6-carboxylate

Methyl 1-acetyl-2-oxoindoline-6-carboxylate Structure
CAS No.
676326-36-6
Chemical Name:
Methyl 1-acetyl-2-oxoindoline-6-carboxylate
Synonyms
Nintedanib-002;methyl-1-acetyl2-oxoindole-6-carboxylate;Methyl 1-acetyl-2-oxoindoline-6-carboxylate;methyl 1-acetyl-2-oxo-3H-indole-6-carboxylate;Methyl 1-acetyl-2-oxo-2,3-dihydro-1H-indole-6-carboxylate;Methyl 1-acetyI-2-oxo-2,3-dihydro-1H-indoIe-6-carboxyIate;TIANFU-CHEM - Methyl 1-acetyl-2-oxoindoline-6-carboxylate;1-Acetyl-2,3-dihydro-2-oxo-1H-indole-6-carboxylic acid methy...;Nintedanib impurity 1/Methyl 1-Acetyl-2-oxoindoline-6-carboxylate;1-acetyl-2-oxo-2,3-dihydro-1H-indole-6-carboxylic acid methyl ester
CBNumber:
CB82520764
Molecular Formula:
C12H11NO4
Molecular Weight:
233.22
MOL File:
676326-36-6.mol
Modify Date:
2023/5/15 10:43:52
Request For Quotation

Methyl 1-acetyl-2-oxoindoline-6-carboxylate Properties

Boiling point 489.5±45.0 °C(Predicted)
Density 1.330
solubility DMSO (Slightly), Methanol (Slightly)
form Solid
pka -1.94±0.20(Predicted)
color Off-White to Pale Red

SAFETY

Risk and Safety Statements

Symbol(GHS) 
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H335
Precautionary statements  P261-P280-P301+P312-P302+P352-P305+P351+P338

Methyl 1-acetyl-2-oxoindoline-6-carboxylate Chemical Properties,Uses,Production

Uses

Methyl 1-Acetyl-2-oxoindoline-6-carboxylate is a reagent used in the preparation of Nintedanib (N478290), an angiokinase inhibitor and is used in the treatment of idiopathic pulmonary fibrosis. Also inhibits the process blood vessel formation which may be used to assist in cancer therapy.

Methyl 1-acetyl-2-oxoindoline-6-carboxylate Preparation Products And Raw materials

Raw materials

Methyl 2-oxoindole-6-carboxylate Acetic anhydride

Preparation Products

(E)-Methyl 1-acetyl-3-(Methoxy(phenyl)Methylene)-2-oxoindoline-6-carboxylate

Methyl 1-acetyl-2-oxoindoline-6-carboxylate Suppliers

Global( 91)Suppliers
Supplier Tel Country ProdList Advantage Inquiry
3A Chemie Private Limited +91-91-712-2564285 +91-9766589212 Maharashtra, India 57 58 Inquiry
Lakshana Biotechnologies Private Limited +91-9010404655 +91-9010404655 Hyderabad, India 20 58 Inquiry
ANWITA APIS +919000311012 Hyderabad, India 198 58 Inquiry
HEMA PHARMACEUTICALS PVT LTD +91-9537936912 +91-9537936912 Gujarat, India 48 58 Inquiry
Shanghai Daken Advanced Materials Co.,Ltd +86-371-66670886 China 16221 58 Inquiry
Henan Tianfu Chemical Co.,Ltd. +86-0371-55170693 +86-19937530512 China 21677 55 Inquiry
career henan chemical co +86-0371-86658258 +8613203830695 China 29901 58 Inquiry
BOC Sciences +1-631-485-4226 United States 19553 58 Inquiry
Chongqing Chemdad Co., Ltd +86-023-6139-8061 +86-86-13650506873 China 39916 58 Inquiry
Fuxin Pharmaceutical +86-021-021-50872116 +8613122107989 China 10297 58 Inquiry
Supplier Advantage
3A Chemie Private Limited 58
Lakshana Biotechnologies Private Limited 58
ANWITA APIS 58
HEMA PHARMACEUTICALS PVT LTD 58
Shanghai Daken Advanced Materials Co.,Ltd 58
Henan Tianfu Chemical Co.,Ltd. 55
career henan chemical co 58
BOC Sciences 58
Chongqing Chemdad Co., Ltd 58
Fuxin Pharmaceutical 58

676326-36-6(Methyl 1-acetyl-2-oxoindoline-6-carboxylate)Related Search:

BIBF 1202 1,3-DiMethyl 2-[4-(Methoxycarbonyl)-2-nitrophenyl]propanedioate N-methyl-N-(4-nitrophenyl)-2-(piperazin-1-yl)acetamide 2-OXO-2,3-DIHYDRO-1H-INDOLE-6-CARBOXYLIC ACID ETHYL ESTER N-(4-aMinophenyl)-2-chloro-N-MethylacetaMide
2-OXO-2,3-DIHYDRO-1H-INDOLE-6-CARBOXYLIC ACID (Z)-methyl 3-(((4-(methylamino)phenyl)amino)(phenyl)methylene)-2-oxoindoline-6-carboxylate (3E)-2,3-Dihydro-3-(methoxyphenylmethylene)-2-oxo-1H-indole-6-carboxylic acid methyl ester 1-(2-chloroacetyl)-2-oxo-2,3-dihydro-1H-indole-6-carboxylic acid methyl ester METHYL OXINDOLE-7-CARBOXYLATE
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Methyl 1-acetyl-2-oxoindoline-6-carboxylate 1-Acetyl-2,3-dihydro-2-oxo-1H-indole-6-carboxylic acid methyl ester 1-acetyl-2-oxo-2,3-dihydro-1H-indole-6-carboxylic acid methyl ester Nintedanib-002 methyl-1-acetyl2-oxoindole-6-carboxylate Nintedanib impurity 1/Methyl 1-Acetyl-2-oxoindoline-6-carboxylate 1H-Indole-6-carboxylic acid, 1-acetyl-2,3-dihydro-2-oxo-, methyl ester methyl 1-acetyl-2-oxo-3H-indole-6-carboxylate Methyl 1-acetyl-2-oxo-2,3-dihydro-1H-indole-6-carboxylate 1-Acetyl-2,3-dihydro-2-oxo-1H-indole-6-carboxylic acid methy... TIANFU-CHEM - Methyl 1-acetyl-2-oxoindoline-6-carboxylate Methyl 1-acetyI-2-oxo-2,3-dihydro-1H-indoIe-6-carboxyIate Methyl 1-acetyl-2-oxo-2,3-dihydro-1H-indole-6-carboxylate(Nintedanib N-acyl oxindole) 676326-36-6