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ChemicalBook > Product Catalog >Organic Chemistry >Carboxylic acids and derivatives >(3E)-2,3-Dihydro-3-(methoxyphenylmethylene)-2-oxo-1H-indole-6-carboxylic acid methyl ester

(3E)-2,3-Dihydro-3-(methoxyphenylmethylene)-2-oxo-1H-indole-6-carboxylic acid methyl ester

(3E)-2,3-Dihydro-3-(methoxyphenylmethylene)-2-oxo-1H-indole-6-carboxylic acid methyl ester Structure
CAS No.
1168150-46-6
Chemical Name:
(3E)-2,3-Dihydro-3-(methoxyphenylmethylene)-2-oxo-1H-indole-6-carboxylic acid methyl ester
Synonyms
(3E)-2;Nintedanib-017;BIBF1120 Intermediate4;Nintedanib impurities3;Nintedanib Impurity 125;Nintedanib Intermediate 4;Nintedanib ethanesulfonate intermediates;oxo-1h-indole-6-carboxylic acid methyl ester;3E-2,3-Dihydro-3-(methoxyphenylmethylene)-2-oxo-1H-indole-6-...;methyl (E)-3-(methoxy(phenyl)methylene)-2-oxoindoline-6-carboxylate
CBNumber:
CB92671010
Molecular Formula:
C18H15NO4
Molecular Weight:
309.32
MOL File:
1168150-46-6.mol
Modify Date:
2023/12/19 16:21:16
Request For Quotation

(3E)-2,3-Dihydro-3-(methoxyphenylmethylene)-2-oxo-1H-indole-6-carboxylic acid methyl ester Properties

Boiling point 523.8±50.0 °C(Predicted)
Density 1.273±0.06 g/cm3(Predicted)
storage temp. Sealed in dry,Room Temperature
solubility DMSO (Slightly), Methanol (Slightly)
pka 10.62±0.20(Predicted)
form Solid
color Light Yellow

SAFETY

Risk and Safety Statements

Symbol(GHS) 
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H335
Precautionary statements  P261-P305+P351+P338

(3E)-2,3-Dihydro-3-(methoxyphenylmethylene)-2-oxo-1H-indole-6-carboxylic acid methyl ester Chemical Properties,Uses,Production

Uses

(E)-Methyl 3-(Methoxy(phenyl)methylene)-2-oxoindoline-6-carboxylate is an intermediate of (E)-Intedanib [I666670]. It is also used as a reactant in the preparation of deuterated derivatives of Nintedanib (N478290), which is angiokinase inhibitor with antitumor activity.

(3E)-2,3-Dihydro-3-(methoxyphenylmethylene)-2-oxo-1H-indole-6-carboxylic acid methyl ester Preparation Products And Raw materials

Raw materials

Preparation Products

(3E)-2,3-Dihydro-3-(methoxyphenylmethylene)-2-oxo-1H-indole-6-carboxylic acid methyl ester Suppliers

Global( 165)Suppliers
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TYNDAL LABS PVT LTD +91-8008166674 +91-8008166674 AndhraPradesh, India 95 58 Inquiry
Synergene Active Ingredients Pvt. Ltd. +91-04023700774 +91-04023700774 Telangana, India 96 58 Inquiry
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Pharmaffiliates Analytics and Synthetics P. Ltd +91-172-5066494 Haryana, India 6739 58 Inquiry
Capot Chemical Co.,Ltd. +86-（0）57185586718 +86-13336195806 China 29730 60 Inquiry
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Supplier Advantage
TYNDAL LABS PVT LTD 58
Synergene Active Ingredients Pvt. Ltd. 58
Equilife Laboratories Pvt Ltd 58
BTC pharm India 58
LUPA PHARMACEUTICALS 58
CLEARSYNTH LABS LTD. 58
A.J Chemicals 58
Pharmaffiliates Analytics and Synthetics P. Ltd 58
Capot Chemical Co.,Ltd. 60
Shanghai Daken Advanced Materials Co.,Ltd 58

1168150-46-6((3E)-2,3-Dihydro-3-(methoxyphenylmethylene)-2-oxo-1H-indole-6-carboxylic acid methyl ester)Related Search:

Methyl 2-oxoindole-6-carboxylate 1-Chloro-4-(trimethoxymethyl)benzene Methyl 1-acetyl-2-oxoindoline-6-carboxylate N-methyl-N-(4-nitrophenyl)-2-(piperazin-1-yl)acetamide N-methyl-N-(4-nitrophenyl)-2-(piperazin-1-yl)acetamide
BIBF 1202 (Z)-methyl 3-(((4-(methylamino)phenyl)amino)(phenyl)methylene)-2-oxoindoline-6-carboxylate Avibactam sodium Nintedanib 1-(2-chloroacetyl)-2-oxo-2,3-dihydro-1H-indole-6-carboxylic acid methyl ester
Avibactam INT 1 BIBF-1120 2-CHLORO-N-METHYL-N-(4-NITROPHENYL)ACETAMIDE 2-broMo-N-Methyl-N-(4-nitrophenyl)acetaMide N-(4-aminophenyl)-N-methyl-2-(4-methylpiperazin-1-yl)acetamide
N-methyl-2-(4-methylpiperazin-1-yl)-N-(4-nitrophenyl)acetamide 1,3-DiMethyl 2-[4-(Methoxycarbonyl)-2-nitrophenyl]propanedioate Nintedanib Ethanesulfonate Salt
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(3E)-2,3-Dihydro-3-(methoxyphenylmethylene)-2-oxo-1H-indole-6-carboxylic acid methyl ester BIBF1120 Intermediate4 Nintedanib ethanesulfonate intermediates (3E)-2,3-Dihydro-3-(methoxyphenylmethylene)-2-oxo-1H-indole-6-carboxylic acid methyl este methyl (E)-3-(methoxy(phenyl)methylene)-2-oxoindoline-6-carboxylate 1H-Indole-6-carboxylic acid, 2,3-dihydro-3-(methoxyphenylmethylene)-2-oxo-, methyl ester, (3E)- Nintedanib Intermediate 4 (3E)-2 3-Dihydro-3-(methoxyphenylmethylene)-2-oxo-1H-indole-6-carboxylic acid methyl ester Nintedanib-017 oxo-1h-indole-6-carboxylic acid methyl ester Nintedanib Impurity 125 3E-2,3-Dihydro-3-(methoxyphenylmethylene)-2-oxo-1H-indole-6-... Nintedanib impurities3 3-[1-Methoxy-1-phenyl-meth-(E)-ylidene]-2-oxo-2,3-dihydro-1H-indole-6-carboxylic acid methyl ester Methyl (3E)-2,3-Dihydro-3-(methoxyphenylmethylene)-2-oxo-1H-indole-6-carboxylate 1168150-46-6