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ChemicalBook > Product Catalog >Organic Chemistry >Carboxylic acids and derivatives >(3E)-2,3-Dihydro-3-(methoxyphenylmethylene)-2-oxo-1H-indole-6-carboxylic acid methyl ester

(3E)-2,3-Dihydro-3-(methoxyphenylmethylene)-2-oxo-1H-indole-6-carboxylic acid methyl ester

(3E)-2,3-Dihydro-3-(methoxyphenylmethylene)-2-oxo-1H-indole-6-carboxylic acid methyl ester Structure
CAS No.
1168150-46-6
Chemical Name:
(3E)-2,3-Dihydro-3-(methoxyphenylmethylene)-2-oxo-1H-indole-6-carboxylic acid methyl ester
Synonyms
(3E)-2;Nintedanib-017;BIBF1120 Intermediate4;Nintedanib impurities3;Nintedanib Impurity 125;Nintedanib Intermediate 4;Nintedanib ethanesulfonate intermediates;oxo-1h-indole-6-carboxylic acid methyl ester;3E-2,3-Dihydro-3-(methoxyphenylmethylene)-2-oxo-1H-indole-6-...;methyl (E)-3-(methoxy(phenyl)methylene)-2-oxoindoline-6-carboxylate
CBNumber:
CB92671010
Molecular Formula:
C18H15NO4
Molecular Weight:
309.32
MOL File:
1168150-46-6.mol
Modify Date:
2023/12/19 16:21:16
Request For Quotation

(3E)-2,3-Dihydro-3-(methoxyphenylmethylene)-2-oxo-1H-indole-6-carboxylic acid methyl ester Properties

Boiling point 523.8±50.0 °C(Predicted)
Density 1.273±0.06 g/cm3(Predicted)
storage temp. Sealed in dry,Room Temperature
solubility DMSO (Slightly), Methanol (Slightly)
pka 10.62±0.20(Predicted)
form Solid
color Light Yellow

SAFETY

Risk and Safety Statements

Symbol(GHS) 
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H335
Precautionary statements  P261-P305+P351+P338

(3E)-2,3-Dihydro-3-(methoxyphenylmethylene)-2-oxo-1H-indole-6-carboxylic acid methyl ester Chemical Properties,Uses,Production

Uses

(E)-Methyl 3-(Methoxy(phenyl)methylene)-2-oxoindoline-6-carboxylate is an intermediate of (E)-Intedanib [I666670]. It is also used as a reactant in the preparation of deuterated derivatives of Nintedanib (N478290), which is angiokinase inhibitor with antitumor activity.

(3E)-2,3-Dihydro-3-(methoxyphenylmethylene)-2-oxo-1H-indole-6-carboxylic acid methyl ester Preparation Products And Raw materials

Raw materials

Preparation Products

(3E)-2,3-Dihydro-3-(methoxyphenylmethylene)-2-oxo-1H-indole-6-carboxylic acid methyl ester Suppliers

Global( 146)Suppliers
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TYNDAL LABS PVT LTD +91-8008166674 +91-8008166674 AndhraPradesh, India 95 58 Inquiry
Synergene Active Ingredients Pvt. Ltd. +91-04023700774 +91-04023700774 Telangana, India 96 58 Inquiry
Equilife Laboratories Pvt Ltd +91-8007935656 +91-9822319778 Maharashtra, India 29 58 Inquiry
CLEARSYNTH LABS LTD. +91-22-45045900 Hyderabad, India 6351 58 Inquiry
A.J Chemicals 91-9810153283 New Delhi, India 6124 58 Inquiry
Pharmaffiliates Analytics and Synthetics P. Ltd +91-172-5066494 Haryana, India 6773 58 Inquiry
Capot Chemical Co.,Ltd. 571-85586718 +8613336195806 China 29798 60 Inquiry
Shanghai Daken Advanced Materials Co.,Ltd +86-371-66670886 China 18646 58 Inquiry
ATK CHEMICAL COMPANY LIMITED +undefined-21-51877795 China 32836 60 Inquiry
career henan chemical co +86-0371-86658258 +8613203830695 China 29888 58 Inquiry
Supplier Advantage
TYNDAL LABS PVT LTD 58
Synergene Active Ingredients Pvt. Ltd. 58
Equilife Laboratories Pvt Ltd 58
CLEARSYNTH LABS LTD. 58
A.J Chemicals 58
Pharmaffiliates Analytics and Synthetics P. Ltd 58
Capot Chemical Co.,Ltd. 60
Shanghai Daken Advanced Materials Co.,Ltd 58
ATK CHEMICAL COMPANY LIMITED 60
career henan chemical co 58

1168150-46-6((3E)-2,3-Dihydro-3-(methoxyphenylmethylene)-2-oxo-1H-indole-6-carboxylic acid methyl ester)Related Search:

Methyl 2-oxoindole-6-carboxylate 1-Chloro-4-(trimethoxymethyl)benzene Methyl 1-acetyl-2-oxoindoline-6-carboxylate N-methyl-N-(4-nitrophenyl)-2-(piperazin-1-yl)acetamide N-methyl-N-(4-nitrophenyl)-2-(piperazin-1-yl)acetamide
BIBF 1202 (Z)-methyl 3-(((4-(methylamino)phenyl)amino)(phenyl)methylene)-2-oxoindoline-6-carboxylate Avibactam sodium Nintedanib 1-(2-chloroacetyl)-2-oxo-2,3-dihydro-1H-indole-6-carboxylic acid methyl ester
Avibactam INT 1 BIBF-1120 2-CHLORO-N-METHYL-N-(4-NITROPHENYL)ACETAMIDE 2-broMo-N-Methyl-N-(4-nitrophenyl)acetaMide N-(4-aminophenyl)-N-methyl-2-(4-methylpiperazin-1-yl)acetamide
N-methyl-2-(4-methylpiperazin-1-yl)-N-(4-nitrophenyl)acetamide 1,3-DiMethyl 2-[4-(Methoxycarbonyl)-2-nitrophenyl]propanedioate Nintedanib Ethanesulfonate Salt
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(3E)-2,3-Dihydro-3-(methoxyphenylmethylene)-2-oxo-1H-indole-6-carboxylic acid methyl ester BIBF1120 Intermediate4 Nintedanib ethanesulfonate intermediates (3E)-2,3-Dihydro-3-(methoxyphenylmethylene)-2-oxo-1H-indole-6-carboxylic acid methyl este methyl (E)-3-(methoxy(phenyl)methylene)-2-oxoindoline-6-carboxylate 1H-Indole-6-carboxylic acid, 2,3-dihydro-3-(methoxyphenylmethylene)-2-oxo-, methyl ester, (3E)- Nintedanib Intermediate 4 (3E)-2 3-Dihydro-3-(methoxyphenylmethylene)-2-oxo-1H-indole-6-carboxylic acid methyl ester Nintedanib-017 oxo-1h-indole-6-carboxylic acid methyl ester Nintedanib Impurity 125 3E-2,3-Dihydro-3-(methoxyphenylmethylene)-2-oxo-1H-indole-6-... Nintedanib impurities3 1168150-46-6