CHLORDIAZEPOXIDE HYDROCHLORIDE
- CAS No.
- 438-41-5
- Chemical Name:
- CHLORDIAZEPOXIDE HYDROCHLORIDE
- Synonyms
- CHLORDIAZEPOXIDE HCL;a-poxide;chlordiazachel;murcil;cebrum;droxol;labican;novosed;timosin;viansin
- CBNumber:
- CB8266675
- Molecular Formula:
- C16H15Cl2N3O
- Molecular Weight:
- 336.22
- MOL File:
- 438-41-5.mol
- MSDS File:
- SDS
- Modify Date:
- 2024/12/18 14:15:30
| Melting point | 213° |
|---|---|
| solubility | Soluble in water, sparingly soluble in ethanol (96 per cent). |
| Stability | Stable. Incompatible with strong oxidizing agents. |
| CAS DataBase Reference | 438-41-5(CAS DataBase Reference) |
| EPA Substance Registry System | Chlordiazepoxide hydrochloride (438-41-5) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS07,GHS08 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H361fd |
| Precautionary statements | P201-P301+P312+P330-P308+P313 |
| Hazard Codes | Xn |
| Risk Statements | 22-62-63-68 |
| Safety Statements | 22-36/37 |
| WGK Germany | 3 |
| RTECS | DE9450000 |
| HS Code | 2933910000 |
| Toxicity | LD50 oral in rabbit: 590mg/kg |
CHLORDIAZEPOXIDE HYDROCHLORIDE Chemical Properties,Uses,Production
Chemical Properties
white crystalline powder
Uses
Sedative-hypnotic.
General Description
Chlordiazepoxide hydrochloride, 7-chloro-2-(methylamino)-5-phenyl-3H-1,4-benzodiazepine4-oxide monohydrochloride (Librium), is well absorbedafter oral administration. Peak plasma levels are reachedin 2 to 4 hours. The half-life of chlordiazepoxide is 6 to30 hours. N-demethylation and hydrolysis of the condensedamidino group are rapid and extensive, producing demoxepamas a major metabolite. Demoxepam can undergo fourdifferent metabolic fates. It is converted principally to itsactive metabolite nordazepam, which is also a major activemetabolite of diazepam, clorazepate, and prazepam.Nordazepam, in turn, is converted principally to active oxazepam(marketed separately), which conjugated to the excretedglucuronide. Because of the long half-life of parentdrug and its active metabolites, this drug is long acting andself-tapering. As with diazepam (vide infra), repeated administrationof chlordiazepoxide can result in accumulationof parent drug and its active metabolites, and thus cause excessivesedation.
Air & Water Reactions
Slightly soluble in water.
Reactivity Profile
Acidic salt of an amine. Materials in this group are generally soluble in water. The resulting solutions contain moderate concentrations of hydrogen ions and have pH's of less than 7.0. They react as acids to neutralize bases. These neutralizations generate heat, but less or far less than is generated by neutralization of inorganic acids, inorganic oxoacids, and carboxylic acid. They usually do not react as either oxidizing agents or reducing agents but such behavior is not impossible.
Hazard
CNS depressant. Manufacture and dosage controlled by law.
Fire Hazard
Flash point data for CHLORDIAZEPOXIDE HYDROCHLORIDE are not available. CHLORDIAZEPOXIDE HYDROCHLORIDE is probably combustible.
Safety Profile
Poison by intraperitoneal and intravenous routes. Moderately toxic by ingestion and subcutaneous routes. An experimental teratogen. Experimental reproductive effects. Human systemic effects: ataxia, dlstorted perceptions, hallucinations, somnolence, and surface EEG changes. Mutation data reported. A minor tranquhzer. When heated to decomposition it emits very toxic fumes of HCl and NOx.
CHLORDIAZEPOXIDE HYDROCHLORIDE Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| Alembic Pharmaceuticals Limited | +91-2652280880 +91-2652280550 | Gujarat, India | 115 | 58 | Inquiry |
| Centaur Pharmaceuticals Pvt Ltd | +912266499100 | Mumbai, India | 33 | 58 | Inquiry |
| Vijaya Pharma And Life Science | +91-8939866271 +91-8939866271 | Tamil Nadu, India | 320 | 58 | Inquiry |
| Flowchem Pharma Pvt Ltd | +91-9606036218 +91-9845055636 | Karnataka, India | 33 | 58 | Inquiry |
| RAKS PHARMA PVT LTD | +91 891 3081555 | New Delhi, India | 65 | 58 | Inquiry |
| CLEARSYNTH LABS LTD. | +91-22-45045900 | Hyderabad, India | 6257 | 58 | Inquiry |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | China | 49374 | 58 | Inquiry |
| Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471 | China | 10473 | 58 | Inquiry |
| Wuhan Yanzhe Technology Co., Ltd | 15527250409 | China | 4169 | 58 | Inquiry |
| FIS FABBRICA ITALIANA SINTETICI SPA | +39 0444 708011 | Italy | 42 | 58 | Inquiry |
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