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ME0328

ME0328 Structure
CAS No.
1445251-22-8
Chemical Name:
ME0328
Synonyms
ME0328;ME0328 ME-0328;ME0328 USP/EP/BP;4-Dihydro-4-oxo-3;ME0328; ME 0328; ME-0328;4-Dihydro-4-oxo-N-[(1S)-1-phenylethyl]-2-quinazolinepropanamide;(S)-3,4-Dihydro-4-oxo-N-(1-phenylethyl)-2-quinazolinepropanamide;2-Quinazolinepropanamide, 3,4-dihydro-4-oxo-N-[(1S)-1-phenylethyl]-;(S)-3-(4-Oxo-3,4-dihydroquinazolin-2-yl)-N-(1-phenylethyl)propanamide;3,4-Dihydro-4-oxo-3,4-Dihydro-4-oxo-N-[(1S)-1-phenylethyl]-2-quinazolinepropanamide
CBNumber:
CB82705099
Molecular Formula:
C19H19N3O2
Molecular Weight:
321.37
MOL File:
1445251-22-8.mol
MSDS File:
SDS
Modify Date:
2023/6/8 9:02:29
Request For Quotation

ME0328 Properties

storage temp. Inert atmosphere,Store in freezer, under -20°C
solubility DMSO: soluble10mg/mL, clear
form powder
color white to beige
Stability Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.

SAFETY

Risk and Safety Statements

Symbol(GHS) 
GHS07
Signal word  Warning
Hazard statements  H302
Precautionary statements  P280-P305+P351+P338
Hazard Codes  Xn
Risk Statements  22-43
Safety Statements  36/37
WGK Germany  3
NFPA 704
0
2 0

ME0328 price More Price(1)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich(India) SML0999 ME0328 ≥98% (HPLC) 1445251-22-8 5MG ₹14807.4 2022-06-14 Buy
Product number Packaging Price Buy
SML0999 5MG ₹14807.4 Buy

ME0328 Chemical Properties,Uses,Production

Description

The poly(ADP-ribose) polymerases (PARPs) are enzymes with roles in DNA repair, apoptosis, inflammation, and other cellular events, particularly in response to reactive oxygen and nitrogen species. ME0328 is an inhibitor of PARP3 (IC50 = 0.89 μM), which is a regulator of DNA repair and mitotic progression. It displays selectivity for PARP3 over 12 other PARP family members. ME0328 is cell permeable and elicits PARP3-specific effects at submicromolar concentrations.

Uses

ME0328 is a potent poly ADP ribose polymerase (PARP) inhibitor with selectivity towards the human ADP-Ribosyltransferase ARTD3/PARP3.

ME0328 Preparation Products And Raw materials

Raw materials

N-(2-Cyano-phenyl)-succinamic acid 3-(4-OXO-3,4-DIHYDRO-QUINAZOLIN-2-YL)-PROPIONIC ACID L-1-Phenylethylamine 2-Aminobenzonitrile

Preparation Products

ME0328 Suppliers

Global( 103)Suppliers
Supplier Tel Country ProdList Advantage Inquiry
A.J Chemicals 91-9810153283 New Delhi, India 6124 58 Inquiry
ATK CHEMICAL COMPANY LIMITED +undefined-21-51877795 China 32836 60 Inquiry
career henan chemical co +86-0371-86658258 +8613203830695 China 29825 58 Inquiry
SHANGHAI T&W PHARMACEUTICAL CO., LTD. +86-021-61551413 +8618813727289 China 5738 58 Inquiry
Dideu Industries Group Limited +86-29-89586680 +86-15129568250 China 24200 58 Inquiry
Zhejiang J&C Biological Technology Co.,Limited +1-2135480471 +1-2135480471 China 10522 58 Inquiry
CR Corporation Limited +8613062833949 China 8647 58 Inquiry
InvivoChem +1-708-310-1919 +1-13798911105 United States 6393 58 Inquiry
TargetMol Chemicals Inc. +1-781-999-5354 United States 19973 58 Inquiry
Nanjing Bicbiotechnology Co., Ltd +86-2552131256 +86-18251840740 China 6000 58 Inquiry
Supplier Advantage
A.J Chemicals 58
ATK CHEMICAL COMPANY LIMITED 60
career henan chemical co 58
SHANGHAI T&W PHARMACEUTICAL CO., LTD. 58
Dideu Industries Group Limited 58
Zhejiang J&C Biological Technology Co.,Limited 58
CR Corporation Limited 58
InvivoChem 58
TargetMol Chemicals Inc. 58
Nanjing Bicbiotechnology Co., Ltd 58

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ME0328 3,4-Dihydro-4-oxo-3,4-Dihydro-4-oxo-N-[(1S)-1-phenylethyl]-2-quinazolinepropanamide (S)-3,4-Dihydro-4-oxo-N-(1-phenylethyl)-2-quinazolinepropanamide ME0328; ME 0328; ME-0328 4-Dihydro-4-oxo-3 4-Dihydro-4-oxo-N-[(1S)-1-phenylethyl]-2-quinazolinepropanamide 2-Quinazolinepropanamide, 3,4-dihydro-4-oxo-N-[(1S)-1-phenylethyl]- ME0328 USP/EP/BP ME0328 ME-0328 (S)-3-(4-Oxo-3,4-dihydroquinazolin-2-yl)-N-(1-phenylethyl)propanamide 1445251-22-8 Inhibitors