Prilocaine
- CAS No.
- 721-50-6
- Chemical Name:
- Prilocaine
- Synonyms
- PRILOCAINE BASE;Aβ25-35;Citanest;Propitocaine;l67;N-(2-methylphenyl)-2-(propylamino)propionamide;L 67;Priloca;astra1512;astra1515
- CBNumber:
- CB8270843
- Molecular Formula:
- C13H20N2O
- Molecular Weight:
- 220.31
- MOL File:
- 721-50-6.mol
- MSDS File:
- SDS
- Modify Date:
- 2024/7/2 8:55:20
| Melting point | 37-38° |
|---|---|
| Boiling point | bp0.1 159-162° |
| Density | 1.0117 (rough estimate) |
| refractive index | nD20 1.5298 |
| storage temp. | 2-8°C |
| solubility | Slightly soluble in water, very soluble in acetone and in ethanol (96 per cent). |
| pka | pKa 7.32 or 7.89 (Uncertain) |
| form | Solid |
| color | White to off-white |
| Water Solubility | 6.169g/L(25 ºC) |
| InChI | InChI=1S/C13H20N2O/c1-4-9-14-11(3)13(16)15-12-8-6-5-7-10(12)2/h5-8,11,14H,4,9H2,1-3H3,(H,15,16) |
| InChIKey | MVFGUOIZUNYYSO-UHFFFAOYSA-N |
| SMILES | C(NC1=CC=CC=C1C)(=O)C(NCCC)C |
| CAS DataBase Reference | 721-50-6(CAS DataBase Reference) |
| NIST Chemistry Reference | Propanamide, n-(2-methylphenyl)-2-(propylamino)-(721-50-6) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H319 |
| Precautionary statements | P301+P312+P330-P305+P351+P338 |
| HS Code | 2924296000 |
Prilocaine Chemical Properties,Uses,Production
Chemical Properties
White or almost white, crystalline powder.
Uses
Prilocaine is a local anesthetic of the amino amide type. Prilocaine is often used in dentistry. Prilocaine is also often combined with lidocaine as a preparation for dermal anesthesia (lidocaine/prilocaine or EMLA), for treatment of conditions like paresthesia.
Definition
ChEBI: An amino acid amide in which N-propyl-DL-alanine and 2-methylaniline have combined to form the amide bond; used as a local anaesthetic.
brand name
lidocaine/prilocaine topical
Brand names: Emla, LiproZonePak, Dolotranz, Livixil Pak, and Anodyne LPT.
General Description
Prilocaine hydrochloride is a water-soluble salt available asa solution for nerve block or infiltration in dental procedures.Prilocaine is used for intravenous regional anesthesiaas the risk of CNS toxicity is low because of the quick metabolism.Prilocaine prepared in the crystal form is used inEMLA for topical administration to decrease painful needlesticks in children. Prilocaine 4% solution should be protectedfrom light and the manufacturer recommends discardingif the solution turns pinkish or slightly darker than lightyellow. Solutions are available in various concentrations upto 4%, with or without epinephrine and with or withoutpreservatives.
Pharmacology
Prilocaine is less toxic than lidocaine, with a high clearance, attributable to metabolism in the lungs, kidneys and liver. It is associated with methaemoglobinaemia at doses >600mg. It is sometimes used at a concentration of 0.5% for the provision of intravenous regional anaesthesia, and a combination of prilocaine 3% with felypressin is available for low-volume local infiltration anaesthesia in dental surgery. A 2% formulation is also available for spinal anaesthesia. Prilocaine is also formulated in a eutectic mixture with lidocaine (EMLA) for topical anaesthesia.
Clinical Use
Prilocaine metabolism has beenstudied extensively in animal models, less is known aboutthe human metabolites or the human CYP enzymes involvedin their formation . The metabolism of prilocainein the liver yields o-toluidine, which is a possiblecarcinogen. Many aromatic amines, including o-toluidinehave been shown to be mutagenic, and metabolites of otoluidinehave been shown to form DNA adducts.Metabolites of o-toluidine are also believed to be responsiblefor the methemoglobinemia observed with prilocaineuse. To decrease the potential for methemoglobinemia, strictadherence to the maximum recommended dose should befollowed. Metabolism of prilocaine is extensive with lessthan 5% of a dose excreted unchanged in the urine.
Prilocaine Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| NB Healthcare Pvt Ltd | +91 7227055467 | Gujarat, India | 37 | 58 | Inquiry |
| SNECOFRi Pvt Ltd | +91-9032850129 +91-9032850129 | Telangana, India | 404 | 58 | Inquiry |
| Chynops Pharma | +919998000404 | Gujarat, India | 39 | 58 | Inquiry |
| Chemino Pharma Ltd | +91-8689897373 +91-8689897373 | Maharashtra, India | 31 | 58 | Inquiry |
| Chempro Pharma Pvt Ltd | +91-9967544178 +91-9967544178 | Maharashtra, India | 4 | 58 | Inquiry |
| Apex Healthcare Limited | +9199825711244 | Gujarat, India | 22 | 58 | Inquiry |
| Gufic Group | +91-2267261000 +91-2267261000 | Maharashtra, India | 22 | 58 | Inquiry |
| Arch Pharmalabs Ltd | +91-2242871210 +91-2242871210 | Maharashtra, India | 51 | 58 | Inquiry |
| Chempifine Chemicals | +91-2225667766 +91-2225667766 | Punjab, India | 144 | 58 | Inquiry |
| Amuna Pharmaceuticals LLP | +91-7940397667 +91-8700823105 | Gujarat, India | 14 | 58 | Inquiry |
| Supplier | Advantage |
|---|---|
| NB Healthcare Pvt Ltd | 58 |
| SNECOFRi Pvt Ltd | 58 |
| Chynops Pharma | 58 |
| Chemino Pharma Ltd | 58 |
| Chempro Pharma Pvt Ltd | 58 |
| Apex Healthcare Limited | 58 |
| Gufic Group | 58 |
| Arch Pharmalabs Ltd | 58 |
| Chempifine Chemicals | 58 |
| Amuna Pharmaceuticals LLP | 58 |
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