8-Anilino-1-naphthalenesulfonic acid
- CAS No.
- 82-76-8
- Chemical Name:
- 8-Anilino-1-naphthalenesulfonic acid
- Synonyms
- ANS;PHENYL PERI ACID;1,8-ANS;ANSA;1-ANILINONAPHTHALENE-8-SULFONIC ACID;PHENYL ACID;ANSA/1,8-ANS;N-PHENYL PERI ACID;fluorescent probes;PHENYL PERI ACID AND SALTS
- CBNumber:
- CB8289935
- Molecular Formula:
- C16H13NO3S
- Molecular Weight:
- 299.34
- MOL File:
- 82-76-8.mol
- Modify Date:
- 2025/2/12 13:10:04
| Melting point | 215-217 °C (dec.)(lit.) |
|---|---|
| Density | 1.409±0.06 g/cm3(Predicted) |
| storage temp. | Sealed in dry,Room Temperature |
| solubility | DMF: soluble50mg/mL |
| pka | 0.19±0.40(Predicted) |
| form | Powder |
| color | Dark green to brown to black |
| Merck | 13,664 |
| BRN | 1843887 |
| InChI | InChI=1S/C16H13NO3S/c18-21(19,20)15-11-5-7-12-6-4-10-14(16(12)15)17-13-8-2-1-3-9-13/h1-11,17H,(H,18,19,20) |
| InChIKey | FWEOQOXTVHGIFQ-UHFFFAOYSA-N |
| SMILES | C1(S(O)(=O)=O)=C2C(C=CC=C2NC2=CC=CC=C2)=CC=C1 |
| CAS DataBase Reference | 82-76-8(CAS DataBase Reference) |
| EPA Substance Registry System | 8-Anilino-1-naphthalenesulfonic acid (82-76-8) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P280a-P304+P340-P305+P351+P338-P405-P501a-P264-P280-P302+P352+P332+P313+P362+P364-P305+P351+P338+P337+P313 | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36-36/37/38 | |||||||||
| Safety Statements | 26-36 | |||||||||
| WGK Germany | - | |||||||||
| TSCA | Yes | |||||||||
| HS Code | 29214980 | |||||||||
| NFPA 704 |
|
8-Anilino-1-naphthalenesulfonic acid price More Price(10)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | A1028 | 8-Anilino-1-naphthalenesulfonic acid | 82-76-8 | 5G | ₹6224.38 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | A1028 | 8-Anilino-1-naphthalenesulfonic acid | 82-76-8 | 25G | ₹19106.13 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | A1028 | 8-Anilino-1-naphthalenesulfonic acid | 82-76-8 | 100G | ₹46709.88 | 2022-06-14 | Buy |
| ALFA India | ALF-J65332-22 | 8-Anilinonaphthalene-1-sulfonic acid, 95% | 82-76-8 | 100g | ₹32093 | 2022-05-26 | Buy |
| ALFA India | ALF-J65332-14 | 8-Anilinonaphthalene-1-sulfonic acid, 95% | 82-76-8 | 25g | ₹8027 | 2022-05-26 | Buy |
8-Anilino-1-naphthalenesulfonic acid Chemical Properties,Uses,Production
Description
1,8-ANS is a fluorescent dye that binds with high affinity to hydrophobic surfaces of proteins. 1,8-ANS has an excitation maximum of 350 nm. It has an emission maximum of 520 nm when free in solution but undergoes a blue shift with an increase in fluorescence intensity when bound to protein; for example, when bound to intestinal fatty acid binding protein (FABP2) it has emission maxima of 468-477 nm. 1,8-ANS binds to low polarity regions of protein surfaces making it well suited for determining the affinity of hydrophobic ligands to their corresponding binding proteins, such as the binding of free fatty acids to FABPs. 1,8-ANS binds to FABP2 with a Kd value of approximately 9.7 μM at 24.5°C.
Chemical Properties
green needles
Uses
8-Anilino-1-naphthalenesulfonic Acid is used as a fluorescent probe to identify hydrophobic sites. Dyes and metabolites.
Definition
CHEBI:8-anilinonaphthalene-1-sulfonic acid is a naphthalenesulfonic acid that is naphthalene-1-sulfonic acid substituted by a phenylamino group at position 8. It has a role as a fluorescent probe. It is an aminonaphthalene and a naphthalenesulfonic acid.
Biotechnological Applications
8-Anilino-1-naphthalenesulfonic acid is a fluorescent dye with high affinity towards hydrophobic surfaces of proteins. It is useful for determining the affinity of hydrophobic ligands to their corresponding binding proteins. 8-Anilino-1-naphthalenesulfonic acid undergoes a blue shift and fluorescence increases when it binds to non-polar regions of a protein surface or membranes. Used as a probe to monitor protein-folding.
8-Anilino-1-naphthalenesulfonic acid Preparation Products And Raw materials
Raw materials
Preparation Products
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