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ChemicalBook > Product Catalog >API >Antipyretic analgesics >Nonsteroidal Anti-Inflammatory Drugs (NSAIDS) >(R)-2-Flurbiprofen

(R)-2-Flurbiprofen

(R)-2-Flurbiprofen Structure
CAS No.
51543-40-9
Chemical Name:
(R)-2-Flurbiprofen
Synonyms
Tarenflurbil;(R)-FLURBIPROFEN;Flurizan;Furbiprofen;2-Flurbiprofen;E-7869;(R)-FL;MPC 7869;Flurbiprofene;l-Flurbiprofen
CBNumber:
CB8302496
Molecular Formula:
C15H13FO2
Molecular Weight:
244.26
MOL File:
51543-40-9.mol
MSDS File:
SDS
Modify Date:
2023/8/11 16:54:45
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(R)-2-Flurbiprofen Properties

Melting point 110-113 °C(lit.)
Boiling point 376.2±30.0 °C(Predicted)
Density 1.199±0.06 g/cm3(Predicted)
storage temp. Store at RT
solubility DMF: 25 mg/ml; DMSO: 10 mg/ml; Ethanol: 25 mg/ml; PBS (pH 7.2): .9 mg/ml
pka 4.14±0.10(Predicted)
form Crystalline Powder
color White to off-white

SAFETY

Risk and Safety Statements

Symbol(GHS) 
GHS06
Signal word  Danger
Hazard statements  H301
Precautionary statements  P301+P310
Hazard Codes  T
Risk Statements  25
Safety Statements  26-36/37/39-45
RIDADR  UN 2811 6.1/PG 2
WGK Germany  3
HS Code  29163900
NFPA 704
0
2 0

(R)-2-Flurbiprofen Chemical Properties,Uses,Production

Description

(R)-Flurbiprofen is a COX-inactive enantiomer of the racemic non-selective COX inhibitor flurbiprofen that has diverse biological activities. It inhibits γ-secretase activity in vitro and, in vivo, it reduces formation of amyloid-β peptide 1-42 (Aβ42) and improves axonal transport in young Aβ-plaque free mice but not old mice with existing Aβ plaques in the Tg2576 transgenic model of Alzheimer''s disease. (R)-Flurbiprofen inhibits NF-kB activation and DNA binding as well as AP-1 DNA binding in RAW 264.7 macrophages and reduces paw edema in a rat model of zymosan-induced inflammation via COX-independent inhibition of NF-κB and AP-1 activation when administered at doses of 1, 3, and 9 mg/kg. It also suppresses prostate tumor cell growth in vitro by inducing p75NTR protein expression and reduces tumor growth and metastasis in multiple mouse models of intestinal neoplasia.

Uses

(R)-2-Flurbiprofen is the R-isomer of Flurbiprofen (F598700), an anti-inflammatory used as an analgesic.

Biochem/physiol Actions

gamma secretase inhibitor; amyloid Abeta 42 lowering agent

(R)-2-Flurbiprofen Preparation Products And Raw materials

Raw materials

Preparation Products

(R)-2-Flurbiprofen Suppliers

Global( 195)Suppliers
Supplier Tel Country ProdList Advantage Inquiry
Pharmaffiliates Analytics and Synthetics P. Ltd +91-172-5066494 Haryana, India 6773 58 Inquiry
A.J Chemicals 91-9810153283 New Delhi, India 6124 58 Inquiry
CLEARSYNTH LABS LTD. +91-22-45045900 Hyderabad, India 6351 58 Inquiry
Metrochem Api Private Limited 09177371731 Hyderabad, India 34 58 Inquiry
Chemicea Pharmaceuticals Pvt Ltd +91-9881765045/+91-8796656135 Pune, India 825 58 Inquiry
Maas Pharma Chemicals +91-9958666224 Delhi, India 1607 58 Inquiry
Pharma Affiliates 172-5066494 Haryana, India 6761 58 Inquiry
Hebei Mojin Biotechnology Co., Ltd +86 13288715578 +8613288715578 China 12495 58 Inquiry
Hefei TNJ Chemical Industry Co.,Ltd. +86-0551-65418679 +8618949832763 China 2989 55 Inquiry
career henan chemical co +86-0371-86658258 +8613203830695 China 29888 58 Inquiry
Supplier Advantage
Pharmaffiliates Analytics and Synthetics P. Ltd 58
A.J Chemicals 58
CLEARSYNTH LABS LTD. 58
Metrochem Api Private Limited 58
Chemicea Pharmaceuticals Pvt Ltd 58
Maas Pharma Chemicals 58
Pharma Affiliates 58
Hebei Mojin Biotechnology Co., Ltd 58
Hefei TNJ Chemical Industry Co.,Ltd. 55
career henan chemical co 58

(R)-2-Flurbiprofen Spectrum

(R)-2-Flurbiprofen(51543-40-9)1HNMR

51543-40-9((R)-2-Flurbiprofen)Related Search:

Kresoxim-methyl Methylparaben Ethyl 2-(Chlorosulfonyl)acetate Biphenyl (Trifluoromethyl)trimethylsilane
2-Fluorophenylacetic acid 2-Phenylisobutyric acid Phenylmethylsulfonyl fluoride α-Lipoic Acid 4-Biphenylacetic acid
Flurbiprofen 2-Methylbenzotrifluoride Bensulfuron methyl Methyl acrylate Trifluoromethanesulfonic anhydride
3-(Trifluoromethyl)benzaldehyde 3-（trifluoromethyl) Cinnamaldehyde Methyl
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(R)-2-Fluoro-α-methyl-1,1'-biphenyl-4-acetic acid (R)-α-Methyl-2-fluoro-1,1'-biphenyl-4-acetic acid (R)-(-)-2-Fluoro-alpha-methyl-4-biphenylacetic acid (Flurbiprofe [1,1'-Biphenyl]-4-aceticacid, 2-fluoro-a-Methyl-,(aR)- MPC 7869 (R)-(-)-2-Fluoro-alpha-methyl-4-biphenylacetic acid 97% (R)-Flurbiprofen, >=99% (R)-2-Flurbiprofenr (R)-2-FLUBIPROFEN (R)-(-)-2-FLUORO-ALPHA-METHYL-4-BIPHENYLACETIC ACID (R)-(-)-FLURBIPROFEN E-7869 (R)-2-fluoro-alpha-methyl[1,1'-biphenyl]-4-acetic acid Flurbiprofene (R)-(-)-2-Fluoro-α-methyl-4-biphenylacetic acid (R)-2-Flurbiprofen [1,1'-Biphenyl]-4-acetic acid, 2-fluoro-α-methyl-, (R)- [1,1'-Biphenyl]-4-acetic acid, 2-fluoro-α-methyl-, (αR)-　 l-Flurbiprofen (R)-(-)-2-FLUORO-ALPHA-METHYL-4-BIPHENYLACETIC ACID (FLURBIPROFEN) (R)-2-Flurbiprofen, Tarenflurbil (R)-2-(2-Fluoro-1,1'-biphenyl-4-yl)propionic acid E7869,Tarenflurbil,MPC7869 (R)-Flurbiprofen (E7869 Flurbiprofen CRS (R)-FL Flurbiprofen (R)-Isomer (R)-(?)-2-Fluoro-α-methyl-4-biphenylacetic acid (R)-2-Flurbiprofen USP/EP/BP (2R)-2-(3-fluoro-4-phenyl-phenyl)propanoic aci R- Flurbiprofen-d4 Flurizan (R)-FLURBIPROFEN Furbiprofen Tarenflurbil 2-Flurbiprofen (R)-2-(2-fluoro-[1,1'-biphenyl]-4-yl)propanoic acid (-)-Flurbiprofen (R)-2-(2-Fluoro-[1,1'-biphenyl]-4-yl)propanoic acid 51543-40-9 1543-40-9 Organic Building Blocks Chiral Building Blocks Asymmetric Synthesis Carboxylic Acids API Pharmaceutical ingredients