Tricresyl Phosphate
- CAS No.
- 1330-78-5
- Chemical Name:
- Tricresyl Phosphate
- Synonyms
- tris(methylphenyl) phosphate;TRITOLYL PHOSPHATE;tricresyl;cresylphosphate;durad;lindol;imols140;kronitex;fyrquel150;nci-c61041
- CBNumber:
- CB8306429
- Molecular Formula:
- C21H21O4P
- Molecular Weight:
- 368.36
- MOL File:
- 1330-78-5.mol
- MSDS File:
- SDS
- Modify Date:
- 2024/7/2 17:04:23
| Melting point | <-40°C |
|---|---|
| Boiling point | 265 °C10 mm Hg(lit.) |
| Density | 1.143 g/mL at 25 °C(lit.) |
| Pour Point | -28 |
| vapor pressure | 0.03 mm Hg ( 25 °C) |
| refractive index |
n |
| Flash point | >230 °F |
| storage temp. | Store below +30°C. |
| solubility | organic solvents: miscible(lit.) |
| form | Powder |
| color | White to off-white |
| Water Solubility | INSOLUBLE |
| Merck | 14,9763 |
| Dielectric constant | 4.0（80℃） |
| Stability | Stable. Incompatible with strong oxidizing agents. May soften some plastics. Hydrolyzes slowly under alkaline conditions. |
| InChIKey | ISNNXHQBIBWQHG-UHFFFAOYSA-N |
| LogP | 5.93 |
| CAS DataBase Reference | 1330-78-5(CAS DataBase Reference) |
| EPA Substance Registry System | Tricresyl phosphate (1330-78-5) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS08,GHS09 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H361f-H410 | |||||||||
| Precautionary statements | P201-P202-P273-P280-P308+P313-P391 | |||||||||
| Hazard Codes | Xn,N,T | |||||||||
| Risk Statements | 21/22-51/53-39/23/24/25-62-50/53 | |||||||||
| Safety Statements | 28-61-45-28A-20/21-60-36/37 | |||||||||
| RIDADR | UN 2574 6.1/PG 2 | |||||||||
| WGK Germany | 2 | |||||||||
| RTECS | TD0175000 | |||||||||
| Autoignition Temperature | 770 °F | |||||||||
| TSCA | Yes | |||||||||
| HS Code | 2919 90 00 | |||||||||
| HazardClass | 6.1 | |||||||||
| PackingGroup | II | |||||||||
| Toxicity | cat,LD50,skin,1500mg/kg (1500mg/kg),BEHAVIORAL: ATAXIAPERIPHERAL NERVE AND SENSATION: FLACCID PARALYSIS WITHOUT ANESTHESIA (USUALLY NEUROMUSCULAR BLOCKAGE),Toxicology Letters. Vol. 1000(Sp, | |||||||||
| NFPA 704 |
|
Tricresyl Phosphate price More Price(8)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | 8.14811 | Tritolyl phosphate for synthesis | 1330-78-5 | 250ML | ₹4530.01 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 8.14811 | Tritolyl phosphate for synthesis | 1330-78-5 | 1L | ₹9290.01 | 2022-06-14 | Buy |
| Sigma-Aldrich | 268917 | Tritolyl phosphate technical grade, mixture of isomers, 90% | 1330-78-5 | 500ML | ₹5520.75 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 268917 | Tritolyl phosphate technical grade, mixture of isomers, 90% | 1330-78-5 | 500ML | ₹5520.75 | 2022-06-14 | Buy |
| TCI Chemicals (India) | P0273 | Tricresyl Phosphate (mixture of isomers) min. 99.0%(total of isomer) | 1330-78-5 | 25G | ₹1800 | 2022-05-26 | Buy |
Tricresyl Phosphate Chemical Properties,Uses,Production
Chemical Properties
Tricresyl phosphate is an isomeric mixture of phosphoric acid esters of cresols. It is an odourless and colourless oily liquid (molar mass 368.4 g/mol, melting point –33°C).
Tricresyl phosphates were used as flame retardants and plasticisers in PVC, nitrocellulose and acrylates.
Uses
Tricresyl phosphate (TCP) is used as a solvent for nitrocellulose esters and numerous natural resins. It is a plasticizer for chlorinated rubber, vinyl plastics, polystyrene and polyacrylic and polymethacrylic esters. Tricresyl phosphate also acts as a binder for resins and nitrocellulose to improve toughness, elasticity and polishing properties of coatings. Alone or associated with hydrocarbons, it is used as an antiwear and antifriction additive in numerous synthetic lubricants, incorrectly termed “oils” by reason of their appearance. It is also employed as a hydraulic fluid. When incorporated in gasoline, tricresyl phosphate counteracts the harmful effects of lead deposits. In addition, it is an excellent fire retardant in many industries.
Usually used as a mediator in the preparation of uranium-sensitive electrode based on membrane containing uranium di-(4-octylphenyl)phosphate as sensor.
Preparation
Tricresyl phosphate is prepared by reaction of cresols with phosphorus oxychloride, phosphoric acid, or phosphorus pentachloride:
OPCl3 + 3 HOC6H4CH3 → OP(OC6H4CH3)3 + 3 HCl
The grades of cresol commonly is a mixture of three isomers (o-, m-, p-). The fact that tricresyl phosphate is derived from a mixture and itself is a mixture ensures that it remains liquid over a wide span of temperatures.
A "refined grade" of tricresyl phosphate is prepared by vacuum distillation, or alternatively by washing with 2% sodium hydroxide and water.
Health Hazard
The tricresyl phosphates (TCPs) are part of a series of organophosphorus compounds which have been shown to cause delayed neurotoxicity. The 1930 outbreak of “ginger jake” paralysis was caused by the contamination of ginger extract by cresyl phosphates, used in the processing of the spice. Since that time, there have been several incidents reported of accidental poisoning of food by tri-o-cresyl phosphate (TOCP). There are few case series reports of occupational exposure in the literature. Acute occupational exposures have been described as causing gastrointestinal symptoms followed by a latent period of days to 4 weeks, after which extremity pain and tingling progress to motor paralysis of the lower extremities up to the thighs, and of the upper extremities to the elbow. There is rarely sensory loss. Partial to total recovery may take years. Fatalities have occurred in high-dose ingestion.
Safety Profile
Moderately toxic by ingestion and skin contact. Human systemic effects by ingestion: flaccid paralysis without anesthesia, motor activity changes, and muscle weakness. An experimental teratogen. Experimental reproductive effects. An eye and skin irritant. Combustible. When heated to decomposition it emits toxic fumes of POx.
Potential Exposure
According to the World Health Organization there is no safe level of exposure to Tricresyl Phosphate(TCP).
TCP has been used as a flame retardant in fabric, plastics and rubbers and as a plasticizer in PVC, lacquers, varnishes and nitrocellulose. It is also used as a heat exchange medium and hydraulic fluid. TCP was detected in all house dust samples gathered in two different North American studies.Biomonitoring studies detected TCP in the breast milk of women in Asia and Sweden. EPA has characterized TCP to exhibit moderate persistence in the environment based on biodegradation studies.
Purification Methods
Dry the ester with CaCl2, percolate it through a column of alumina, then distil it under a vacuum. Alernatively pass it through a packed column of alumina at 150o, with a counter-current stream of nitrogen, under reduced pressure, to remove residual traces of volatile impurities. It also crystallises from pet ether (b 60-80o). [Cherbuliez in Organic Phosphorus Compounds (Kosolapoff & Maier eds) Wiley-Interscience Vol 6 pp 454-457 1973.]
Tricresyl Phosphate Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| Sagar Speciality Chemicals Private Limited | +91-9619603699 +91-9619603699 | Maharashtra, India | 48 | 58 | Inquiry |
| Adishank Chemicals Pvt Ltd | +91-9821112126 +91-9324787427 | Maharashtra, India | 7 | 58 | Inquiry |
| KLJ Group | +91-1141427427 +91-1145371400 | New Delhi, India | 29 | 58 | Inquiry |
| Sandhya Group | +91-9167722041 +91-9167722043 | Maharashtra, India | 22 | 58 | Inquiry |
| Tina Organics | +91-9212987098 +91-9212987098 | New Delhi, India | 4 | 58 | Inquiry |
| AKASH PHARMA EXPORTS | +91-9388123451 +91-9846039283 | Kerela, India | 470 | 58 | Inquiry |
| Scientific OEM | +91-22- 2343 7546 / 2341 3094 | New Delhi, India | 1996 | 38 | Inquiry |
| ALPHA CHEMIKA | +91-22-22061123 +91-22-66382501 | Mumbai, India | 1681 | 43 | Inquiry |
| CHEMSWORTH | +91-261-2397244 | New Delhi, India | 6707 | 30 | Inquiry |
| Otto Chemie Pvt. Ltd. | +91 9820041841 | Mumbai, India | 5873 | 58 | Inquiry |
| Supplier | Advantage |
|---|---|
| Sagar Speciality Chemicals Private Limited | 58 |
| Adishank Chemicals Pvt Ltd | 58 |
| KLJ Group | 58 |
| Sandhya Group | 58 |
| Tina Organics | 58 |
| AKASH PHARMA EXPORTS | 58 |
| Scientific OEM | 38 |
| ALPHA CHEMIKA | 43 |
| CHEMSWORTH | 30 |
| Otto Chemie Pvt. Ltd. | 58 |
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