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NS 1619

NS 1619 Structure
CAS No.
153587-01-0
Chemical Name:
NS 1619
Synonyms
NS 161;NS 1619;NS1619;NS 1619;NS-1619, 10 mM in DMSO;NS 1619, KCa1.1 channel activator;NS 1619 (1,3-DIHYDRO-1-(2-HYDROXY-5-(TRI FLUOROMETHYL)PHEN;1-(2-hydroxy-5-(trifluoroMethyl)phenyl)-5-(trifluoroMethyl)-1H-b;1-(2-Hydroxy-5-(Trifluoromethyl)Phenyl)-5-(Trifluoromethyl)-1H-Benzo[D]Imidazol-2-Ol;1-(2-hydroxy-5-(trifluoromethyl)phenyl)-5-(trifluoromethyl)-1H-benzo[d]imidazol-2(3H)-one;1,3-DIHYDRO-1-[2-HYDROXY-5-(TRIFLUOROMETHYL)PHENYL]-5-(TRIFLUOROMETHYL)-2H-BENZIMIDAZOL-2-ONE
CBNumber:
CB8359809
Molecular Formula:
C15H8F6N2O2
Molecular Weight:
362.23
MOL File:
153587-01-0.mol
Modify Date:
2025/4/17 18:22:24
Request For Quotation

NS 1619 Properties

Density 1.563±0.06 g/cm3(Predicted)
storage temp. Inert atmosphere,2-8°C
solubility 45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: 0.47 mg/mL
pka 8.32±0.48(Predicted)
form solid
color white
Water Solubility 45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: 0.47mg/mL
ethanol: 26.6mg/mL
0.1 M NaOH: 5.2mg/mL
DMSO: 5.3mg/mL
H2O: insoluble

SAFETY

Risk and Safety Statements

Symbol(GHS) 
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H335
Precautionary statements  P261-P305+P351+P338
WGK Germany  3

NS 1619 price More Price(2)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich(India) N170 NS 1619 powder 153587-01-0 5MG ₹12230 2022-06-14 Buy
Sigma-Aldrich(India) N170 NS 1619 powder 153587-01-0 25MG ₹49340 2022-06-14 Buy
Product number Packaging Price Buy
N170 5MG ₹12230 Buy
N170 25MG ₹49340 Buy

NS 1619 Chemical Properties,Uses,Production

Uses

NS 1619 is a large conductance calcium-activated potassium channels (BKCa) activator and has been shown to induce precondition in the heart.

Definition

ChEBI: A member of the class of benzimidazoles that is 1,3-dihydro-2H-benzimidazol-2-one in which the hydrogens at positions 1 and 5 are replaced are replaced by 2-hydroxy-5-(trifluoromethyl)phenyl and trifluoromethyl groups, respectively. It i an opener/activator of the large-conductance calcium-activated potassium channel (Bkca).

Biochem/physiol Actions

NS 1619 is a selective large conductance Ca2+-activated K+-channel activator. The compound is known for its vasodilating and anti-proliferative properties. It is studied that NS 1619 can protect cardiac muscle against ischemia and reperfusion injury.

NS 1619 Preparation Products And Raw materials

Raw materials

Preparation Products

NS 1619 Suppliers

Global( 110)Suppliers
Supplier Tel Country ProdList Advantage Inquiry
TCI Chemicals (India) Pvt. Ltd. 1800 425 7889 New Delhi, India 6768 58 Inquiry
A.J Chemicals 91-9810153283 New Delhi, India 6100 58 Inquiry
ATK CHEMICAL COMPANY LIMITED +undefined-21-51877795 China 33024 60 Inquiry
career henan chemical co +86-0371-86658258 +8613203830695 China 29808 58 Inquiry
TargetMol Chemicals Inc. +1-781-999-5354 +1-00000000000 United States 32159 58 Inquiry
Henan Alfa Chemical Co., Ltd +8615838112936 China 13194 58 Inquiry
InvivoChem +1-708-310-1919 +1-13798911105 United States 6391 58 Inquiry
RR Scientific LLC +86-13917743231 United States 878 58 Inquiry
LEAP CHEM CO., LTD. +86-852-30606658 China 24727 58 Inquiry
TargetMol Chemicals Inc. United States 38630 58 Inquiry
Supplier Advantage
TCI Chemicals (India) Pvt. Ltd. 58
A.J Chemicals 58
ATK CHEMICAL COMPANY LIMITED 60
career henan chemical co 58
TargetMol Chemicals Inc. 58
Henan Alfa Chemical Co., Ltd 58
InvivoChem 58
RR Scientific LLC 58
LEAP CHEM CO., LTD. 58
TargetMol Chemicals Inc. 58

NS 1619 Spectrum

NS 1619(153587-01-0)1HNMR

153587-01-0(NS 1619)Related Search:

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APAMIN PENITREM A NS1643 PNU 37883 hydrochloride TRAM-34
5-HYDROXYDECANOIC ACID SODIUM SALT CLOFILIUM TOSYLATE Gabapentin-lactam PAXILLINE 2-amino-1-(4-chlorobenzyl)-5-trifluoromethylbenzimidazole
NS 11394 Selexipag N-(4-PHENYLSULFONYLPHENYL)-3,3,3-TRIFLUORO-2-HYDROXY-2-METHYLPROPANAMIDE
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NS 1619 NS 1619 (1,3-DIHYDRO-1-(2-HYDROXY-5-(TRI FLUOROMETHYL)PHEN 1,3-DIHYDRO-1-[2-HYDROXY-5-(TRIFLUOROMETHYL)PHENYL]-5-(TRIFLUOROMETHYL)-2H-BENZIMIDAZOL-2-ONE 1-(2-hydroxy-5-(trifluoromethyl)phenyl)-5-(trifluoromethyl)-1H-benzo[d]imidazol-2(3H)-one 1-(2-hydroxy-5-(trifluoroMethyl)phenyl)-5-(trifluoroMethyl)-1H-b NS1619;NS 1619 NS 161 2H-Benzimidazol-2-one, 1,3-dihydro-1-[2-hydroxy-5-(trifluoromethyl)phenyl]-5-(trifluoromethyl)- 1-[2-Hydroxy-5-(trifluoromethyl)phenyl]-5-(trifluoromethyl)-1,3-dihydro-2H-benzimidazol-2-one 1-[2-Hydroxy-5-(trifluoromethyl)phenyl]-5-(trifluoromethyl)-1,3-dihydro-2H-benzo[d]imidazol-2-one 1-(2-Hydroxy-5-(Trifluoromethyl)Phenyl)-5-(Trifluoromethyl)-1H-Benzo[D]Imidazol-2-Ol NS 1619, KCa1.1 channel activator NS-1619, 10 mM in DMSO 153587-01-0 C15H8F6N2O2 Monovalent Ion Channels Ion Channels Voltage-gated Ion Channels Potassium Channel Modulators Cell Signaling and Neuroscience Cell Biology BioChemical API